Autonomic Nervous System Activation During Social Cognition Tasks in Patients With Schizophrenia and Their Unaffected Relatives
Open accessAbstract
OBJECTIVE: The objective of the study was to determine whether patients with schizophrenia and their unaffected first-degree relatives have abnormal autonomic nervous system (ANS) responses to social cognition tasks. BACKGROUND: Social cognition impairments are significant in schizophrenia. ANS activity has been shown to be abnormal in schizophrenia patients, and some of the abnormalities seem to be shared by patients' unaffected relatives. METHOD: Heart rate variability (HRV) was measured at rest and during social cognition tasks, in patients with schizophrenia, their nonpsychotic first-degree relatives, and matched healthy controls (n=19 in each group). RESULTS: Social cognition tasks induced a shortening of the RR interval in unaffected relatives, but not in patients. Social cognition tasks generated decreases in high-frequency (indicating cardiac vagal activity) and low-frequency (reflecting predominantly sympathetic activity) HRV in patients. In relatives, the decrease occurred in the high-frequency component only. Low-frequency HRV was higher in patients during a theory of mind task than a control task. These changes were not observed in the controls. CONCLUSIONS: Social cognitive tasks induce a pattern of peripheral autonomic activity different from that seen in generic arousal responses, and this pattern is abnormal in schizophrenia patients. Autonomic abnormalities in unaffected first-degree relatives seem restricted to the parasympathetic division of the ANS.
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Jauregui et al. found that patients with schizophrenia displayed abnormal decreases in both HF-HRV and LF-HRV in response to a variety of social cognition tasks, as compared to healthy controls and unaffected first degree relatives.
“For instance, Jauregui et al.80 found that patients with SCZ displayed abnormal decreases in both HF-HRV and LF-HRV in response to a variety of social cognition tasks, as compared to HCs and unaffected first degree relatives.”
From Autonomic nervous system dysfunction in schizophrenia: impact on cognitive and metabolic health (2021) · cites this paper as [80]
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“Additionally, evidence suggests that impairments in executive functioning and social cognition are associated with lower HF-HRV in SZ (Hamilton et al., 2014; Jáuregui et al., 2011; Kim et al., 2019; Mathewson, Jetha, Goldberg, & Schmidt, 2012).”
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“There are, however, 2 studies [51,52] in which social functioning is linked to a lower LF/HF ratio, indicative of an imbalance in autonomic regulation (higher sympathetic activity or lower parasympathetic activity).”
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“…altered balance is reflected in elevated heart rates and a loss of variability and complexity, which is well documented in drug-naïve or unmedicated patients with schizophrenia (B€ar et al. 2005; Clamor et al. 2016) and their healthy first-degree relatives (B€ar et al. 2010; Jauregui et al. 2011).”
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“Specifically, Jáuregui et al. (2011) also found a positive correlation between total FPRT scores and HF-HRV, while most of the other included studies focused on AToM ability as assessed by the Reading the Mind in the Eyes Test (RMET) (Zammuto et al. 2021).”
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Altered Heart Rate Variability During Rest in Schizophrenia: A State Marker
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Increased QT variability index as a marker for a cardiac autonomic dysregulation in schizophrenia
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“Schizophrenia patients exhibit an abnormal autonomic response to mental stress [26] or social cognition tasks [27].”
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The influence of interest in tasks on the autonomic nervous system
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“For patients with schizophrenia, a task involving social cognition can decrease both parasympathetic and sympathetic activities (Jauregui et al., 2011).”
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“…importance for neuroscience studies’ design and interpretation because the autonomic nervous system (ANS) activity is associated with a myriad of social cognitive processes (Jáuregui et al., 2011; Quintana et al., 2012), as we have recently shown for cognitive empathy (Cosme et al., 2021, 2022).”
BackgroundCardiac Autonomic Dysfunction in Patients with Schizophrenia and Their Healthy Relatives
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A Cross-Sectional Study of Social Exclusion in Schizophrenia
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- Authors
- Jáuregui, O. I., Costanzo, E. Y., de Achával, D., Villarreal, M. F., Chu, E., Mora, M. C., Vigo, D. E., Castro, M. N., Leiguarda, R. C., Bär, K.-J., & Guinjoan, S. M.
- Affiliations
- Fundación para la Lucha contra las Enfermedades Neurológicas de la Infancia (AR)
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- UCL Queen Square Institute of Neurology (GB)
- Jena University Hospital (DE)
- Corresponding author
- Jáuregui, Oscar Ignacio
- Costanzo, Elsa Y.
- Villarreal, Mirta F.
- Mora, Martina C.
- Castro, Mariana N.
- Guinjoan, Salvador M.
- ORCID
- Venue
- Cognitive and Behavioral Neurology
- Published
- 2011-12
- Volume
- 24
- Issue
- 4
- Pages
- 194-203
- ISSN
- 1543-3633 (ISSN-L)
- OpenAlex
- W2331604996
- Cited by
- 33
- References
- 52
- Citations by year
- 2025: 8 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 2 · 2014: 2 · 2013: 1
- FWCI
- 0.66
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- cc-by-nc-sa
- Locations
- Cognitive and Behavioral Neurology (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-sa)
- Funders
- Fleni
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Keywords
- schizophrenia, social cognition, autonomic nervous system, heart rate variability, theory of mind, first-degree relatives, parasympathetic activity, sympathetic activity, cardiac vagal activity, RR interval
- MeSH terms
- Adult, Aged, Autonomic Nervous System, Cognition Disorders, Family, Female, Heart Rate, Humans, Male, Middle Aged, Psychological Tests, Psychomotor Performance, Schizophrenia, Schizophrenic Psychology, Case-Control Studies
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