Retinal amyloid peptides and complement factor H in transgenic models of Alzheimer's disease

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

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Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

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Intraneuronal β-Amyloid Aggregates, Neurodegeneration, and Neuron Loss in Transgenic Mice with Five Familial Alzheimer's Disease Mutations: Potential Factors in Amyloid Plaque Formation

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Amyloid Precursor Protein Processing and Alzheimer's Disease

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Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

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A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease

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An NF-κB-sensitive Micro RNA-146a-mediated Inflammatory Circuit in Alzheimer Disease and in Stressed Human Brain Cells

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Retinal thickness in patients with mild cognitive impairment and Alzheimer's disease

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Differential Regulation of Interleukin-1 Receptor-associated Kinase-1 (IRAK-1) and IRAK-2 by MicroRNA-146a and NF-κB in Stressed Human Astroglial Cells and in Alzheimer Disease

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Age-Related Amyloid β Deposition in Transgenic Mice Overexpressing Both Alzheimer Mutant Presenilin 1 and Amyloid β Precursor Protein Swedish Mutant Is Not Associated with Global Neuronal Loss

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Retinal amyloid pathology and proof-of-concept imaging trial in Alzheimer’s disease

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The role of microglia in retinal neurodegeneration: Alzheimer’s disease, parkinson, and glaucoma.

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Melanopsin retinal ganglion cell loss in A lzheimer disease

Morgia, C. L., Ross‐Cisneros, F. N., Koronyo, Y., Hannibal, J., Gallassi, R., Cantalupo, G., Sambati, L., Pan, B. X., Tozer, K. R., Barboni, P., et al. (2015) · Annals of Neurology · doi:10.1002/ana.24548 · Cited by 400

Non-invasive in vivo hyperspectral imaging of the retina for potential biomarker use in Alzheimer’s disease

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Ocular indicators of Alzheimer’s: exploring disease in the retina

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Identification of early pericyte loss and vascular amyloidosis in Alzheimer’s disease retina

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Retinal imaging in Alzheimer's and neurodegenerative diseases

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Revolution of Alzheimer Precision Neurology. Passageway of Systems Biology and Neurophysiology

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Optical Coherence Tomography in Alzheimer’s Disease and Other Neurodegenerative Diseases

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Microbial-generated amyloids and Alzheimer's disease (AD)

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Past, present and future role of retinal imaging in neurodegenerative disease

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Developing retinal biomarkers for the earliest stages of Alzheimer's disease: What we know, what we don't, and how to move forward

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Beta‐Amyloid, Phospho‐Tau and Alpha‐Synuclein Deposits Similar to Those in the Brain Are Not Identified in the Eyes of A lzheimer's and P arkinson's Disease Patients

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Neuroinflammatory Processes, A1 Astrocyte Activation and Protein Aggregation in the Retina of Alzheimer’s Disease Patients, Possible Biomarkers for Early Diagnosis

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Long-Term Pioglitazone Treatment Improves Learning and Attenuates Pathological Markers in a Mouse Model of Alzheimer's Disease

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Microbiome-generated amyloid and potential impact on amyloidogenesis in Alzheimer's disease (AD).

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Regulation of Complement Factor H (CFH) by Multiple miRNAs in Alzheimer’s Disease (AD) Brain

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Common micro RNAs (miRNAs) target complement factor H (CFH) regulation in Alzheimer's disease (AD) and in age-related macular degeneration (AMD).

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microRNA-34a-Mediated Down-Regulation of the Microglial-Enriched Triggering Receptor and Phagocytosis-Sensor TREM2 in Age-Related Macular Degeneration

Bhattacharjee, S., Zhao, Y., Dua, P., Rogaev, E. I., & Lukiw, W. J. (2016) · PLOS ONE · doi:10.1371/journal.pone.0150211 · Cited by 147

Functional and morphological changes of the retinal vessels in Alzheimer’s disease and mild cognitive impairment

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Retinal changes in Alzheimer's disease— integrated prospects of imaging, functional and molecular advances

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Microbial Sources of Amyloid and Relevance to Amyloidogenesis and Alzheimer’s Disease (AD)

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Patterns of Retinal Ganglion Cell Damage in Neurodegenerative Disorders: Parvocellular vs Magnocellular Degeneration in Optical Coherence Tomography Studies

Morgia, C. L., Vito, L. D., Carelli, V., & Carbonelli, M. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00710 · Cited by 132

Structural and Functional Impairment of the Retina and Optic Nerve in Alzheimer’s Disease

Moschos, M. M., Markopoulos, I., Chatziralli, I., ROUVAS, A. A., Papageorgiou, S. G., Ladas, I., & Vassilopoulos, D. (2012) · Current Alzheimer Research · doi:10.2174/156720512802455340 · Cited by 129

Alzheimer’s Retinopathy: Seeing Disease in the Eyes

Mirzaei, N., Shi, H., Oviatt, M., Doustar, J., Rentsendorj, A., Fuchs, D.-T. S., Sheyn, J., Black, K. L., Koronyo, Y., & Koronyo‐Hamaoui, M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00921 · Cited by 136

Light-Induced Pupillary Responses in Alzheimer's Disease

Chougule, P. S., Najjar, R. P., Finkelstein, M. T., Kandiah, N., & Miléa, D. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00360 · Cited by 122

Retinal Ganglion Cells and Circadian Rhythms in Alzheimer’s Disease, Parkinson’s Disease, and Beyond

Morgia, C. L., Ross‐Cisneros, F. N., Sadun, A. A., & Carelli, V. (2017) · Frontiers in Neurology · doi:10.3389/fneur.2017.00162 · Cited by 116

Macular Thickness Measurements with Frequency Domain-OCT for Quantification of Retinal Neural Loss and its Correlation with Cognitive Impairment in Alzheimerʼs Disease

Cunha, L. P., Lopes, L. C., Costa-Cunha, L. V. F., Costa, C. F., Pires, L. A., Almeida, A. L. M., & Monteiro, M. L. R. (2016) · PLoS ONE · doi:10.1371/journal.pone.0153830 · Cited by 109

Alzheimer's disease pathophysiology in the Retina

Gaire, B. P., Koronyo, Y., Fuchs, D.-T. S., Shi, H., Rentsendorj, A., Danziger, R., Vit, J., Mirzaei, N., Doustar, J., Sheyn, J., et al. (2024) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2024.101273 · Cited by 107

Blood Proteomic Profiling in Inherited (ATTRm) and Acquired (ATTRwt) Forms of Transthyretin-Associated Cardiac Amyloidosis

Chan, G. G., Koch, C. M., & Connors, L. H. (2017) · Journal of Proteome Research · doi:10.1021/acs.jproteome.6b00998 · Cited by 99

Retinal Vasculopathy in Alzheimer’s Disease

Shi, H., Koronyo, Y., Rentsendorj, A., Fuchs, D.-T. S., Sheyn, J., Black, K. L., Mirzaei, N., & Koronyo‐Hamaoui, M. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.731614 · Cited by 91

Human Gut Microbiota in Health and Alzheimer’s Disease

Szablewski, L. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170908 · Cited by 96

The Retina in Alzheimer's Disease: Histomorphometric Analysis of an Ophthalmologic Biomarker

Asanad, S., Ross‐Cisneros, F. N., Nassisi, M., Barrón, E., Karanjia, R., & Sadun, A. A. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-25966 · Cited by 86

Ocular Manifestations of Alzheimer’s and Other Neurodegenerative Diseases: The Prospect of the Eye as a Tool for the Early Diagnosis of Alzheimer’s Disease

Colligris, P., de Lara, M. J. P., Colligris, B., & Pintor, J. J. (2018) · Journal of Ophthalmology · doi:10.1155/2018/8538573 · Cited by 84

The Retina as a Window or Mirror of the Brain Changes Detected in Alzheimer’s Disease: Critical Aspects to Unravel

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Neurodegeneration in Alzheimer’s disease and glaucoma: overlaps and missing links

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Amyloid Beta Immunoreactivity in the Retinal Ganglion Cell Layer of the Alzheimer’s Eye

Lee, S., Jiang, K., McIlmoyle, B. J., To, E. C., Xu, Q., Hirsch‐Reinshagen, V., Mackenzie, I. R., Hsiung, G. R., Eadie, B. D., Šarunic, M. V., et al. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00758 · Cited by 77

Intracellular amyloid beta alters the tight junction of retinal pigment epithelium in 5XFAD mice

Park, S. W., Kim, J. H., Mook‐Jung, I., Kim, K.-W., Park, W. J., Park, K. H., & Kim, J. H. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.03.008 · Cited by 78

Studying micro RNA Function and Dysfunction in Alzheimer’s Disease

Lukiw, W. J., Андреева, Т. В., Grigorenko, A. P., & Rogaev, E. I. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2012.00327 · Cited by 76

The retina as a window to early dysfunctions of Alzheimer's disease following studies with a 5xFAD mouse model

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Up-Regulation of miRNA-146a in Progressive, Age-Related Inflammatory Neurodegenerative Disorders of the Human CNS

Alexandrov, P. N., Dua, P., & Lukiw, W. J. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00181 · Cited by 66

Retinal capillary degeneration and blood-retinal barrier disruption in murine models of Alzheimer’s disease

Shi, H., Koronyo, Y., Fuchs, D.-T. S., Sheyn, J., Wawrowsky, K., Lahiri, S., Black, K. L., & Koronyo‐Hamaoui, M. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01076-4 · Cited by 71

One protein, multiple pathologies: multifaceted involvement of amyloid β in neurodegenerative disorders of the brain and retina

Gupta, V., Gupta, V. B., Chitranshi, N., Gangoda, S. V. S., Wall, R. V., Abbasi, M., Golzan, M., Dheer, Y., Shah, T. M., Avolio, A. P., et al. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2295-x · Cited by 70

microRNAs in Neurodegeneration: Current Findings and Potential Impacts

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Retinal Functional and Structural Changes in the 5xFAD Mouse Model of Alzheimer’s Disease

Lim, J. K. H., Li, Q.-X., He, Z., Vingrys, A. J., Chinnery, H. R., Mullen, J., Bui, B. V., & Nguyen, C. T. O. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00862 · Cited by 65

Beta-Amyloid Precursor Protein (βAPP) Processing in Alzheimer’s Disease (AD) and Age-Related Macular Degeneration (AMD)

Zhao, Y., Bhattacharjee, S., Jones, B. M., Hill, J. M., Clément, C., Sambamurti, K., Dua, P., & Lukiw, W. J. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8886-3 · Cited by 65

Retina pathology as a target for biomarkers for Alzheimer's disease: Current status, ophthalmopathological background, challenges, and future directions

Alber, J., Bouwman, F. H., den Haan, J., Rissman, R. A., Groef, L. D., Koronyo‐Hamaoui, M., Lengyel, I., & Thal, D. R. (2023) · Alzheimer s & Dementia · doi:10.1002/alz.13529 · Cited by 64

Beta-amyloid sequelae in the eye: a critical review on its diagnostic significance and clinical relevance in Alzheimer’s disease

Shah, T. M., Gupta, S. M., Chatterjee, P., Campbell, M., & Martins, R. N. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.251 · Cited by 62

Sectoral segmentation of retinal amyloid imaging in subjects with cognitive decline

Dumitrascu, O. M., Lyden, P. D., Torbati, T., Sheyn, J., Sherzai, A. Z., Sherzai, D., Sherman, D. S., Rosenberry, R., Cheng, S. C., Johnson, K., et al. (2020) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1002/dad2.12109 · Cited by 61

The AppNL-G-F mouse retina is a site for preclinical Alzheimer’s disease diagnosis and research

Vandenabeele, M., Veys, L., Lemmens, S., Hadoux, X., Gelders, G., Masin, L., Serneels, L., Theunis, J., Saito, T., Saido, T. C., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01102-5 · Cited by 63

Ocular manifestations of Alzheimer's disease in animal models

Parnell, M., Guo, L., Abdi, M., & Cordeiro, M. F. (2012) · International Journal of Alzheimer s Disease · doi:10.1155/2012/786494 · Cited by 56

Levels of Retinal Amyloid-β Correlate with Levels of Retinal IAPP and Hippocampal Amyloid-β in Neuropathologically Evaluated Individuals

Schultz, N., Byman, E., Bank, T. N. B., & Wennström, M. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190868 · Cited by 55

Hyperphosphorylation of tau protein by calpain regulation in retina of Alzheimer's disease transgenic mouse

Zhao, H., Chang, R., Che, H., Wang, J., Yang, L., Wei, F., Xia, Y., Li, N., Ma, Q., & Wang, X. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.06.026 · Cited by 53

Emerging ocular biomarkers of Alzheimer disease

van Wijngaarden, P., Hadoux, X., Alwan, M., Keel, S., & Dirani, M. (2016) · Clinical and Experimental Ophthalmology · doi:10.1111/ceo.12872 · Cited by 51

Retinal nerve fiber layer thickness predicts CSF amyloid/tau before cognitive decline

Asanad, S., Fantini, M., Sultan, W., Nassisi, M., Felix, C. M., Wu, J., Karanjia, R., Ross‐Cisneros, F. N., Sagare, A. P., Zloković, B. V., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0232785 · Cited by 55

Parallels between retinal and brain pathology and response to immunotherapy in old, late‐stage Alzheimer's disease mouse models

Doustar, J., Rentsendorj, A., Torbati, T., Regis, G. C., Fuchs, D.-T. S., Sheyn, J., Mirzaei, N., Graham, S. L., Shah, P. K., Mastali, M., et al. (2020) · Aging Cell · doi:10.1111/acel.13246 · Cited by 47

Microglial Activation in the Retina of a Triple-Transgenic Alzheimer’s Disease Mouse Model (3xTg-AD)

Salobrar‐García, E., Rodrigues‐Neves, A. C., Ramirez, A. I., de Hoz, R., Fernández‐Albarral, J. A., López‐Cuenca, I., Ramirez, J. M., Ambrósio, A. F., & Salazar, J. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21030816 · Cited by 45

Reduction of amyloid-beta levels in mouse eye tissues by intra-vitreally delivered neprilysin

Parthasarathy, R., Chow, K. M., Derafshi, Z., Fautsch, M. P., Hetling, J. R., Rodgers, D. W., Hersh, L. B., & Pepperberg, D. R. (2015) · Experimental Eye Research · doi:10.1016/j.exer.2015.06.027 · Cited by 44

The retina: A window in which to view the pathogenesis of Alzheimer’s disease

Zhang, J., Shi, L., & Shen, Y. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101590 · Cited by 48

The retinal ganglion cell layer reflects neurodegenerative changes in cognitively unimpaired individuals

López‐de‐Eguileta, A., López‐García, S., Lage, C., Pozueta, A., García‐Martínez, M., Kazimierczak, M., Bravo, M., Irure, J., López‐Hoyos, M., Muñoz, P., et al. (2022) · Alzheimer s Research & Therapy · doi:10.1186/s13195-022-00998-6 · Cited by 41

Progressive inflammatory pathology in the retina of aluminum-fed 5xFAD transgenic mice

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Inflammation: The Link between Neural and Vascular Impairment in the Diabetic Retina and Therapeutic Implications

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MicroRNA (miRNA): Sequence and stability, viroid-like properties, and disease association in the CNS

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Olfactory delayed matching to sample performance in mice: Sex differences in the 5XFAD mouse model of Alzheimer's disease

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Aluminum-Induced Amyloidogenesis and Impairment in the Clearance of Amyloid Peptides from the Central Nervous System in Alzheimer’s Disease

Zhao, Y., Hill, J. M., Bhattacharjee, S., Percy, M. E., Pogue, A. I., & Lukiw, W. J. (2014) · Frontiers in Neurology · doi:10.3389/fneur.2014.00167 · Cited by 36

Retinal Dysfunction in Alzheimer’s Disease and Implications for Biomarkers

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Retinal imaging biomarkers of Alzheimer's disease: A systematic review and meta‐analysis of studies using brain amyloid beta status for case definition

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Retinal ganglion cell vulnerability to pathogenic tau in Alzheimer’s disease

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Induction of the pro-inflammatory NF-kB-sensitive miRNA-146a by human neurotrophic viruses

Hill, J. M., Clément, C., Zhao, Y., & Lukiw, W. J. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.00043 · Cited by 34

Systemic delivery of a specific antibody targeting the pathological N-terminal truncated tau peptide reduces retinal degeneration in a mouse model of Alzheimer’s Disease

Latina, V., Giacovazzo, G., Cordella, F., Balzamino, B. O., Micera, A., Varano, M., Marchetti, C., Malerba, F., Florio, R., Ercole, B. B., et al. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01138-1 · Cited by 33

Translational opportunities for amyloid-targeting fluorophores

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Identification of retinal oligomeric, citrullinated, and other tau isoforms in early and advanced AD and relations to disease status

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알쯔하이머병 모델 쥐의 망막색소상피에서 아밀로이드 베타 42의 세포 내 발현에 관한 연구

박성욱 (2012) · Seoul National University Open Repository (Seoul National University)