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Cited by 20Suicide and Self-Harm StudiesTreatment of Major DepressionAnxiety, Depression, Psychometrics, Treatment, Cognitive Processes

The DOI matches its Crossref record; 82 of the 83 references it cites were found in a registry or an index.

Persistence of suicidal ideation within acute phase treatment of major depressive disorder: analysis of clinical predictors

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Olgiati, Paolo, Serretti, Alessandro·2022·International Clinical Psychopharmacology
DOI 10.1097/yic.0000000000000416
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Abstract

Suicidal ideation (SI) is common in major depressive disorder (MDD), and it is a risk factor for suicidal behaviour. Antidepressants are effective in reducing SI, but in some subjects, SI may persist for weeks. This study aimed to disentangle the contribution of baseline clinical characteristics in SI nonremission at week 6. Research involved 198 outpatients with MDD and SI collected within the Combining Medications to Enhance Depression Outcomes trial and treated with different antidepressant combinations. Although SI decreased from baseline to week 6 (P < 0.0001), 78 patients (39%) failed to achieve SI remission. Insomnia [OR, 0.72; 95% confidence interval (CI), 0.52–0.99], reduced need for sleep (OR, 0.75; 95% CI, 0.58–0.99), self-confidence (OR, 0.52; 95% CI, 0.32–0.82), cheerfulness (OR, 0.57; 95% CI, 0.33–0.98), and comorbid panic disorder (OR, 0.93; 95% CI, 0.87–0.99) at baseline were associated with lack of SI remission after controlling for baseline depression and SI scores. The combination of baseline SI and insomnia was moderately effective in predicting the lack of SI remission, with a specificity of 80% (95% CI, 72–87%) and an NPV of 68% (95% CI, 63–72%). In individuals with MDD and SI, the presence of insomnia and bipolar features should prompt a search for more effective treatment solutions in order to favour SI remission and prevent suicidal behaviour.

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Metadata

Authors
Olgiati, P., & Serretti, A.
Affiliations
University of Bologna (IT)
Corresponding author
Serretti, Alessandro
ORCID
Venue
International Clinical Psychopharmacology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2022-07-07
Volume
37
Issue
5
Pages
193-200
ISSN
0268-1315 (ISSN-L)
DOI
10.1097/yic.0000000000000416
OpenAlex
W4282570432
Cited by
20
References
83
Citations by year
2026: 1 · 2025: 4 · 2024: 5 · 2023: 6 · 2022: 3
FWCI
4.11
Type
journal article
Language
en
Open access
Licence
Locations
  • International Clinical Psychopharmacology (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Archivio istituzionale della ricerca (Alma Mater Studiorum Università di Bologna) (submittedVersion, cc-by)
  • IRIS eCampus Telematic University (Università degli Studi eCampus) (submittedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health
Topics
  • Social Sciences › Psychology › Clinical Psychology › Suicide and Self-Harm Studies
  • Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Keywords
suicidal ideation, major depressive disorder, antidepressant treatment, insomnia, self-confidence, cheerfulness, suicide risk
MeSH terms
Antidepressive Agents, Major Depressive Disorder, Humans, Sleep Initiation and Maintenance Disorders, Risk Factors, Suicidal Ideation

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