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Urbanization and anticoagulant poisons promote immune dysfunction in bobcats
Abstract
Understanding how human activities influence immune response to environmental stressors can support biodiversity conservation across increasingly urbanizing landscapes. We studied a bobcat (Lynx rufus) population in urban southern California that experienced a rapid population decline from 2002–2005 due to notoedric mange. Because anticoagulant rodenticide (AR) exposure was an underlying complication in mange deaths, we aimed to understand sublethal contributions of urbanization and ARs on 65 biochemical markers of immune and organ function. Variance in immunological variables was primarily associated with AR exposure and secondarily with urbanization. Use of urban habitat and AR exposure has pervasive, complex and predictable effects on biochemical markers of immune and organ function in free-ranging bobcats that include impacts on neutrophil, lymphocyte and cytokine populations, total bilirubin and phosphorus. We find evidence of both inflammatory response and immune suppression associated with urban land use and rat poison exposure that could influence susceptibility to opportunistic infections. Consequently, AR exposure may influence mortality and has population-level effects, as previous work in the focal population has revealed substantial mortality caused by mange infection. The secondary effects of anticoagulant exposure may be a worldwide, largely unrecognized problem affecting a variety of vertebrate species in human-dominated environments.
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“Further, this observation makes it unlikely that the change seen in coyotes is caused by the presence of anthropogenic toxins, such as anticoagulant rodenticide that has been reported to affect urban bobcat populations (Riley et al., 2007; Serieys et al., 2018), and that has been suggested as a possible cause of anthropogenic stress in coyotes (Murray et al., 2015).”
From Microbiomes in Canidae (2021) · cites this paper as Serieys et al., 2018
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Cited by
Land use-induced spillover: a call to action to safeguard environmental, animal, and human health
Plowright, R. K., Reaser, J. K., Locke, H., Woodley, S. J., Patz, J. A., Becker, D. J., Oppler, G., Hudson, P. J., & Tabor, G. M. (2021) · The Lancet Planetary Health · doi:10.1016/s2542-5196(21)00031-0 · Cited by 426
So overt it's covert: Wildlife coloration in the city
Kreling, S. E. S. (2023) · BioScience · doi:10.1093/biosci/biad021 · Cited by 14
Biles, T. L., Beck, H., & Masters, B. S. (2021) · Ecology and Evolution · doi:10.1002/ece3.8449 · Cited by 4
Metadata
- Authors
- Serieys, L. E. K., Lea, A. J., Epeldegui, M., Armenta, T. C., Moriarty, J., VandeWoude, S., Carver, S., Foley, J., Wayne, R. K., Riley, S. P. D., & Uittenbogaart, C. H.
- Affiliations
- Department of Ecology and Evolutionary Biology, University of California, Los Angeles, CA, USA
- Department of Biology, Duke University, Box 90338, Durham, NC, USA
- UCLA AIDS Institute and Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA, USA
- Santa Monica Mountains National Recreation Area, National Park Service, 401 West Hillcrest Drive, Thousand Oaks, CA 91360, USA
- Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA
- School of Biological Sciences, University of Tasmania, Tasmania, Australia
- Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, Davis, CA, USA
- Departments of Pediatrics and Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, CA, USA
- Venue
- Proceedings of the Royal Society B: Biological Sciences
- Publisher
- The Royal Society
- Published
- 2018-01-17
- Volume
- 285
- Issue
- 1871
- Pages
- 20172533
- ISSN
- 0962-8452
- 1471-2954
- Cited by
- 57
- References
- 1
- Language
- en
- Licence
- royalsociety.org/journals/ethics-policies/data-sharing-mining/ (tdm)
- Funders
- National Science Foundation EID (0723676)
- Christine Stevens Wildlife Award
- National Institute of Health (AI-28697, CA-16042)
- Santa Monica Bay Audubon Society
- HESKA Corporation
- Panthera SCAF
- National Science Foundation Graduate Research Fellowship
- National Park Service
- University of California, Los Angeles
- NSF EID (1413925)
- Santa Monica Mountains Fund
- Summerlee Foundation
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- Serieys, L. E. K., Lea, A. J., Epeldegui, M., Armenta, T. C., Moriarty, J., VandeWoude, S., Carver, S., Foley, J., Wayne, R. K., Riley, S. P. D., & Uittenbogaart, C. H. (2018). Urbanization and anticoagulant poisons promote immune dysfunction in bobcats. Proceedings of the Royal Society B: Biological Sciences. https://doi.org/10.1098/rspb.2017.2533
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