The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Antibiotics as signalling molecules
Open accessAbstract
We present the argument that the majority of low-molecular-weight organic compounds made and secreted by microbes play roles as cell-signalling molecules in the environment. Of the large number of compounds isolated to date, only a small fraction have been shown to possess useful therapeutic antibiotic activity. However, most microbial metabolites modulate gene transcription at low concentrations, and this is proposed to be the primary effect of the compounds in the maintenance of microbial communities in the environment. Thus, microbial metabolites constitute a large collection of cell-signalling molecules that regulate gene expression in microbial populations and possibly the interactions of these populations with the surrounding organisms.
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Cites
Prokaryotes: The unseen majority
Whitman, W. B., Coleman, D. C., & Wiebe, W. J. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6578 · Cited by 4,871 · cited 2×
“Wilson once stated that ‘microbial diversity is beyond practical calculation’; nonetheless, estimates based on experimental observations have been made (Whitman et al. 1998) and some current figures are shown in table 1.”
BackgroundBacteriocins: Developing innate immunity for food
Cotter, P. D., Hill, C., & Ross, R. P. (2005) · Nature Reviews Microbiology · doi:10.1038/nrmicro1273 · Cited by 2,380
Sampling the Antibiotic Resistome
D'Costa, V. M., McGrann, K. M., Hughes, D. W., & Wright, G. D. (2006) · Science · doi:10.1126/science.1120800 · Cited by 1,594
β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
Rothstein, J. D., Patel, S., Regan, M. R., Haenggeli, C., Huang, Y. H., Bergles, D. E., Jin, L., Dykes Hoberg, M., Vidensky, S., Chung, D. S., et al. (2005) · Nature · doi:10.1038/nature03180 · Cited by 1,518
Small molecules: the missing link in the central dogma
Schreiber, S. L. (2005) · Nature Chemical Biology · doi:10.1038/nchembio0705-64 · Cited by 306
Cited by
Biofilm-Specific Antibiotic Resistance
Mah, T.-F. (2012) · Future Microbiology · doi:10.2217/fmb.12.76 · Cited by 504
Streptomyces as symbionts: an emerging and widespread theme?
Seipke, R. F., Kaltenpoth, M., & Hutchings, M. I. (2012) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2011.00313.x · Cited by 417
The natural history of antibiotics
Clardy, J., Fischbach, M. A., & Currie, C. R. (2009) · Current Biology · doi:10.1016/j.cub.2009.04.001 · Cited by 402
LaFayette, S. L., Collins, C., Zaas, A. K., Schell, W. A., Betancourt-Quiroz, M., Gunatilaka, A. A. L., Perfect, J. R., & Cowen, L. E. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001069 · Cited by 329
The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype.
Cowen, L. E. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1835 · Cited by 311
Metadata
- Authors
- Yim, G., Huimi Wang, H., & Davies FRS, J.
- Venue
- Philosophical Transactions of the Royal Society B: Biological Sciences
- Publisher
- The Royal Society
- Published
- 2007-03-13
- Volume
- 362
- Issue
- 1483
- Pages
- 1195-1200
- ISSN
- 0962-8436 (ISSN-L)
- 1471-2970
- OpenAlex
- W2158797036
- Cited by
- 495
- References
- 5
- FWCI
- 12.93
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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