The DOI matches its Crossref record; 146 of the 146 references it cites were found in a registry or an index.
The role of the local microbial ecosystem in respiratory health and disease
Open accessAbstract
Respiratory tract infections are a major global health concern, accounting for high morbidity and mortality, especially in young children and elderly individuals. Traditionally, highly common bacterial respiratory tract infections, including otitis media and pneumonia, were thought to be caused by a limited number of pathogens including Streptococcus pneumoniae and Haemophilus influenzae. However, these pathogens are also frequently observed commensal residents of the upper respiratory tract (URT) and form—together with harmless commensal bacteria, viruses and fungi—intricate ecological networks, collectively known as the ‘microbiome’. Analogous to the gut microbiome, the respiratory microbiome at equilibrium is thought to be beneficial to the host by priming the immune system and providing colonization resistance, while an imbalanced ecosystem might predispose to bacterial overgrowth and development of respiratory infections. We postulate that specific ecological perturbations of the bacterial communities in the URT can occur in response to various lifestyle or environmental effectors, leading to diminished colonization resistance, loss of containment of newly acquired or resident pathogens, preluding bacterial overgrowth, ultimately resulting in local or systemic bacterial infections. Here, we review the current body of literature regarding niche-specific upper respiratory microbiota profiles within human hosts and the changes occurring within these profiles that are associated with respiratory infections.
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Cited by
The microbiota of the respiratory tract: gatekeeper to respiratory health
Man, W. H., de Steenhuijsen Piters, W. A. A., & Bogaert, D. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2017.14 · Cited by 1,384
Self-citationThe microbiota protects against respiratory infection via GM-CSF signaling
Brown, R. L., Sequeira, R. P., & Clarke, T. B. (2017) · Nature Communications · doi:10.1038/s41467-017-01803-x · Cited by 378
Bosch, A. A. T. M., Piters, W. A. A. D. S., van Houten, M. A., Chu, M. L. J. N., Biesbroek, G., Kool, J., Pernet, P., de Groot, P.-K. C. M., Eijkemans, M. J. C., Keijser, B. J. F., et al. (2017) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201703-0554oc · Cited by 325
Self-citationGut-Lung Axis: The Microbial Contributions and Clinical Implications
He, Y., Wen, Q., Yao, F., Xu, D., Huang, Y., & Wang, J. (2017) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2016.1176988 · Cited by 301
Man, W. H., Clerc, M., de Steenhuijsen Piters, W. A. A., van Houten, M. A., Chu, M. L. J. N., Kool, J., Keijser, B. J. F., Sanders, E. A. M., & Bogaert, D. (2019) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201810-1993oc · Cited by 89
Metadata
- Authors
- de Steenhuijsen Piters, W. A. A., Sanders, E. A. M., & Bogaert, D.
- Venue
- Philosophical Transactions of the Royal Society B: Biological Sciences
- Publisher
- The Royal Society
- Published
- 2015-08-19
- Volume
- 370
- Issue
- 1675
- Pages
- 20140294
- ISSN
- 0962-8436 (ISSN-L)
- 1471-2970
- OpenAlex
- W1907046813
- Cited by
- 283
- References
- 146
- FWCI
- 8.75
- Type
- journal article
- Language
- en
- Open access
- green
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