Candida albicans Biofilms Are Generally Devoid of Persister Cells
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Abstract
Candida albicans is known for its ability to form biofilms, which are communities of microorganisms embedded in an extracellular matrix developing on different surfaces. Biofilms are highly tolerant to antifungal therapy.
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Antifungal persistence is not a common phenomenon.
“suggesting that antifungal persistence is not a common phenomenon [79,82].”
From Antifungal persistence: Clinical relevance and mechanisms (2025) · cites this paper as [79]
The Discussion reports no detectable persister cells in 92 of 98 C. albicans strains tested, supporting the suggestion that persistence was uncommon in those experiments. But it explicitly limits the finding to biofilms grown in vitro and does not establish how common antifungal persistence is across fungi or in hosts. (LLM, conf=0.84)
Experimental — accuracy not yet measuredNot all biofilm-forming C. albicans strains necessarily generate persister cells.
“A separate investigation demonstrated that not all biofilm-forming C. albicans strains necessarily generate persister cells, which supported the aforementioned observation [79].”
From Antifungal persistence: Clinical relevance and mechanisms (2025) · cites this paper as [79]
AmB-tolerant persister cells are absent in biofilms of some Candida spp.
“Notably, AmB-tolerant persister cells are absent in biofilms of some Candida spp., suggesting that antifungal persistence is not a common phenomenon [79,82].”
From Antifungal persistence: Clinical relevance and mechanisms (2025) · cites this paper as [79]
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- Authors
- Denega, I., d’Enfert, C., & Bachellier-Bassi, S.
- Affiliations
- Institut Pasteur (FR)
- Institut Pasteur, INRA, Unité Biologie et Pathogénicité Fongiques, Paris, France
- Venue
- Antimicrobial Agents and Chemotherapy
- Publisher
- American Society for Microbiology
- Published
- 2019-05
- Volume
- 63
- Issue
- 5
- Pages
- 1-9
- ISSN
- 0066-4804 (ISSN-L)
- 1098-6596
- PMC
- PMC6496073
- OpenAlex
- W2949863082
- Cited by
- 32
- References
- 43
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 2 · 2022: 6 · 2021: 5 · 2020: 7
- FWCI
- 3.45
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- Antimicrobial Agents and Chemotherapy (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by-nc-nd)
- HAL (submittedVersion, cc-by-nc-sa)
- Funders
- Institut Carnot Pasteur Microbes & Santé
- LabEx IBEID (ANR-10-LABX-62-IBEID)
- EC | Horizon 2020 Framework Programme (665807)
- Topics
- Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
- Keywords
- Candida albicans, biofilm, persister cells, antifungal tolerance, extracellular matrix, fungal persistence
- MeSH terms
- Antifungal Agents, Candida albicans, Microbial Sensitivity Tests, Biofilms
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