The MAP kinase Mkc1p is activated under different stress conditions in Candida albicans

Navarro-García, Federico; Eisman, Blanca; Fiuza, Sonia M.; Nombela, César; Pla, Jesús

doi:10.1099/mic.0.28038-0

Cited by 134Fungal and yeast genetics researchAntifungal resistance and susceptibilityBacterial Genetics and Biotechnology

The MAP kinase Mkc1p is activated under different stress conditions in Candida albicans

Navarro-García, Federico, Eisman, Blanca, Fiuza, Sonia M., Nombela, César, Pla, Jesús·2005·Microbiology

DOI 10.1099/mic.0.28038-0

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Abstract

Candida albicans is an opportunistic pathogen that has adapted to live and grow in the human body as its natural environment. Under these conditions, this fungus faces numerous challenges, including oxidative, osmotic and enzymic processes that may damage external and internal structures. In view of the key role of MAP kinase signalling pathways in the physiology of C. albicans, the effect of agents mimicking in vivo environmental conditions on the activation of the p42-44 MAP kinases has been analysed. It has been found that Mkc1p is phosphorylated in the presence of oxidative stress, changes in osmotic pressure, cell wall damage and a decrease in the growth temperature. This phosphorylation is dependent on Pkc1p, indicating that both proteins operate in the same signalling pathway in C. albicans. Under some stimuli, the phosphorylation of Mkc1p required the presence of Hog1p, the MAP kinase of the high osmolarity glycerol (HOG) pathway. This suggests the existence of a new regulatory role, at least under some conditions, for these MAP kinase pathways in yeast.

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In C. albicans, the PKC pathway is activated under diverse stress conditions and works in concert with calcineurin and the high osmolarity glycerol pathway to regulate chitin synthesis, which can enhance tolerance to echinocandins.
“In C. albicans, the PKC pathway is activated under diverse stress conditions [43] and works in concert with calcineurin and the high osmolarity glycerol pathway to regulate chitin synthesis, which can enhance tolerance to echinocandins [15],[16].”
From Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin (2009) · cites this paper as [43]
Mkc1 is activated by hydrogen peroxide but is not required for survival under this condition.
“For example, Mkc1, the mitogen activated protein kinase (MAPK) in the PKC pathway, is activated by hydrogen peroxide but is not required for survival under this condition [43].”
From Hsp90 Governs Echinocandin Resistance in the Pathogenic Yeast Candida albicans via Calcineurin (2009) · cites this paper as [43]

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“For example, Mkc1, the mitogen activated protein kinase (MAPK) in the PKC pathway, is activated by hydrogen peroxide but is not required for survival under this condition [43].”
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Correspondence
Eisman, B., & Fiuza, S. M. (2005)
The MAP kinase signal transduction network in Candida albicans
Alonso‐Monge, R., Román, E., Nombela, C., & Plá, J. (2006) · Microbiology · doi:10.1099/mic.0.28616-0 · Cited by 263 · see citing works
Signal Transduction Pathways in Candida albicans: A Focus on MAPK regulation during infection
Mehrotra, P. (2024) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.14577279
The Role of MAPK Signal Transduction Pathways in the Response to Oxidative Stress in the Fungal Pathogen Candida albicans: Implications in Virulence
Herrero de Dios, C., Roman, E., Alonso Monge, R., & Pla, J. (2010) · Current Protein & Peptide Science · doi:10.2174/138920310794557655 · Cited by 55 · see citing works
Characterization of a Candida albicans Mutant Defective in All MAPKs Highlights the Major Role of Hog1 in the MAPK Signaling Network
Correia, I., Wilson, D., Hube, B., & Plá, J. (2020) · Journal of Fungi · doi:10.3390/jof6040230 · Cited by 23 · see citing works

Authors: Navarro-García, F., Eisman, B., Fiuza, S. M., Nombela, C., & Pla, J.
Affiliations: Dept Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Plaza de Ramón y Cajal s/n. E-28040 Madrid, Spain
Universidad Complutense de Madrid (ES)
ORCID: Nombela, César
Venue: Microbiology
Publisher: Microbiology Society
Published: 2005-08-01
Volume: 151
Issue: 8
Pages: 2737-2749
ISSN: 1350-0872 (ISSN-L)
1465-2080
DOI: 10.1099/mic.0.28038-0
OpenAlex: W2147289133
Cited by: 134
References: 47
Citations by year: 2026: 3 · 2025: 8 · 2024: 5 · 2023: 3 · 2022: 4 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 4 · 2017: 5 · 2016: 11 · 2015: 12 · 2014: 7 · 2013: 8 · 2012: 7
FWCI: 2.13
Type: journal article
Language: en
Open access: closed
Locations: Microbiology (publishedVersion)
PubMed (publishedVersion)
Funders: Pfizer
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Keywords: Candida albicans, MAPK signaling, Hog1p, HOG pathway, oxidative stress, osmotic stress, cell wall damage, cold stress, protein phosphorylation, stress response
MeSH terms: Candida albicans, Osmotic Pressure, Protein Kinase C, Temperature, Signal Transduction, Gene Expression Regulation, Fungal, Heat-Shock Response, Mitogen-Activated Protein Kinases, MAP Kinase Signaling System

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The MAP kinase Mkc1p is activated under different stress conditions in Candida albicans

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