The Hog1 Mitogen-Activated Protein Kinase Is Essential in the Oxidative Stress Response and Chlamydospore Formation in Candidaalbicans

Alonso-Monge, Rebeca; Navarro-García, Federico; Román, Elvira; Negredo, Ana I.; Eisman, Blanca; Nombela, César; Pla, Jesús

doi:10.1128/ec.2.2.351-361.2003

Cited by 308Fungal and yeast genetics researchRedox biology and oxidative stressAntifungal resistance and susceptibility

The Hog1 Mitogen-Activated Protein Kinase Is Essential in the Oxidative Stress Response and Chlamydospore Formation in Candidaalbicans

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Alonso-Monge, Rebeca, Navarro-García, Federico, Román, Elvira, Negredo, Ana I., Eisman, Blanca, Nombela, César, Pla, Jesús·2003·Eukaryotic Cell

DOI 10.1128/ec.2.2.351-361.2003PMC PMC154845

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Abstract

Candidaalbicans mutants with mutations in mitogen-activated protein (MAP) kinase HOG1 displayed an increased sensitivity to agents producing reactive oxygen species, such as oxidants (menadione, hydrogen peroxide, or potassium superoxide), and UV light. Consistent with this finding,C.albicans Hog1 was activated not only in response to an increase in external osmolarity, as happens with its Saccharomycescerevisiae homologue, but also in response to hydrogen peroxide. The Hog1-mediated response to oxidative stress was different from that of transcription factor Cap1, the homologue of S.cerevisiae Yap1, as shown by the different sensitivities to oxidants and the kinetics of cell death of cap1 Δ,hog1, and hog1cap1 Δ mutants. Deletion of CAP1 did not influence the level of Hog1 phosphorylation, and deletion of HOG1 did not affect Cap1 nuclear localization. Moreover, we show that the HOG1 gene plays a role in chlamydospore formation, another oxygen-related morphogenetic event, as demonstrated by the fact that hog1 cells were unable to generate these thick-walled structures in several media through a mechanism different from that of the EFG1 regulator. This is the first demonstration of the role of the Hog1-mediated MAP kinase pathway in resistance to oxidative stress in pathogenic fungi, and it allows us to propose a molecular model for the oxidative stress response in C.albicans.

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In C. albicans, Hog1 MAPK is a major regulator of fungal stress response, morphogenesis, and virulence.
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Exploring the metabolic and genetic control of gene expression on a genomic scale.
Derisi, J., Iyer, V., & Brown, P. (1997) · Science · doi:10.1126/science.278.5338.680 · Cited by 4,832 · see citing works
A MAP Kinase Targeted by Endotoxin and Hyperosmolarity in Mammalian Cells
Han, J., Lee, J. D., Bibbs, L., & Ulevitch, R. J. (1994) · Science · doi:10.1126/science.7914033 · Cited by 2,647 · see citing works
Isogenic strain construction and gene mapping in Candida albicans.
Fonzi, W. A., & Irwin, M. Y. (1993) · Genetics · doi:10.1093/genetics/134.3.717 · Cited by 1,695 · see citing works
Candida and candidosis
Odds, F. C. (1979) · Medical Entomology and Zoology · Cited by 1,297 · see citing works
Isolation of the Candida albicans gene for orotidine-5′-phosphate decarboxylase by complementation of S. cerevisiae ura3 and E. coli pyrF mutations
Gillum, A. M., Tsay, E. Y. H., & Kirsch, D. R. (1984) · Molecular and General Genetics MGG · doi:10.1007/bf00328721 · Cited by 1,253 · see citing works
An Osmosensing Signal Transduction Pathway in Yeast
Brewster, J. L., de Valoir, T., Dwyer, N. D., Winter, E., & Gustin, M. C. (1993) · Science · doi:10.1126/science.7681220 · Cited by 1,248 · see citing works
Oxidative stress and the molecular biology of antioxidant defenses.
Scandalios, J. G. (1997) · Cited by 1,037 · see citing works
Parallel signal processing among mammalian MAPKs
Cano, E., & Mahadevan, L. C. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)88978-1 · Cited by 1,009 · see citing works
H2O2 release from human granulocytes during phagocytosis. I. Documentation, quantitation, and some regulating factors.
Root, R. K., Metcalf, J. A., Oshino, N., & Chance, B. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108024 · Cited by 646 · see citing works
Efg1p, an essential regulator of morphogenesis of the human pathogen Candida albicans, is a member of a conserved class of bHLH proteins regulating morphogenetic processes in fungi
Stoldt, V. R., Sonneborn, A., Leuker, C. E., & Ernst, J. F. (1997) · The EMBO Journal · doi:10.1093/emboj/16.8.1982 · Cited by 595 · see citing works
H2O2 Release from Human Granulocytes during Phagocytosis
Root, R. K., & Metcalf, J. A. (1977) · Journal of Clinical Investigation · doi:10.1172/jci108886 · Cited by 587 · see citing works
An Osmosensing Signal Transduction Pathway in Mammalian Cells
Galcheva-Gargova, Z., Dérijard, B., Wu, I., & Davis, R. J. (1994) · Science · doi:10.1126/science.8047888 · Cited by 569 · see citing works
Yap1 and Skn7 Control Two Specialized Oxidative Stress Response Regulons in Yeast
Lee, J., Godon, C., Lagniel, G., Spector, D., Garin, J., Labarre, J., & Tolédano, M. B. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.23.16040 · Cited by 567 · see citing works
H2O2 sensing through oxidation of the Yap1 transcription factor
Delaunay, A., Isnard, A., & Tolédano, M. B. (2000) · The EMBO Journal · doi:10.1093/emboj/19.19.5157 · Cited by 529 · see citing works
THE ROLE OF THE SIGMA FACTOR σs (KatF) IN BACTERIAL GLOBAL REGULATION
Loewen, P. C., & Hengge‐Aronis, R. (1994) · Annual Review of Microbiology · doi:10.1146/annurev.mi.48.100194.000413 · Cited by 526 · see citing works
Regulation of yAP‐1 nuclear localization in response to oxidative stress
Kuge, S., Jones, N., & Nomoto, A. (1997) · The EMBO Journal · doi:10.1093/emboj/16.7.1710 · Cited by 445 · see citing works
OxyR, a positive regulator of hydrogen peroxide-inducible genes in Escherichia coli and Salmonella typhimurium, is homologous to a family of bacterial regulatory proteins.
Christman, M. F., Storz, G., & Ames, B. N. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.10.3484 · Cited by 436 · see citing works
Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast.Preprint
Shiozaki, K., & Russell, P. R. (1996) · Genes & Development · doi:10.1101/gad.10.18.2276 · Cited by 427 · see citing works
Regulation of gene expression by oxygen in Saccharomyces cerevisiae
Zitomer, R. S., & Lowry, C. V. (1992) · Microbiological Reviews · doi:10.1128/mr.56.1.1-11.1992 · Cited by 413 · see citing works
The Hog1 MAPK prevents cross talk between the HOG and pheromone response MAPK pathways in Saccharomyces cerevisiaePreprint
O’Rourke, S. M., & Herskowitz, I. (1998) · Genes & Development · doi:10.1101/gad.12.18.2874 · Cited by 396 · see citing works
The Atf1 transcription factor is a target for the Sty1 stress-activated MAP kinase pathway in fission yeast.Preprint
Wilkinson, M. G., Samuels, M., Takeda, T., Toone, W. M., Shieh, J., Toda, T., Millar, J. B. A., & Jones, N. (1996) · Genes & Development · doi:10.1101/gad.10.18.2289 · Cited by 373 · see citing works
Role of the Mitogen-Activated Protein Kinase Hog1p in Morphogenesis and Virulence of Candida albicans
Alonso-Monge, R., Navarro-García, F., Molero, G., Diez-Orejas, R., Gustin, M., Pla, J., Sánchez, M., & Nombela, C. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.10.3058-3068.1999 · Cited by 344 · see citing works
Self-citation
Regulatory Mechanisms for Modulation of Signaling through the Cell Integrity Slt2-mediated Pathway in Saccharomyces cerevisiae
Martı́n, H., Rodrı́guez-Pachón, J. M., Ruiz, C., Nombela, C., & Molina, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.2.1511 · Cited by 343 · see citing works
Self-citation
Regulation of the fission yeast transcription factor Pap1 by oxidative stress: requirement for the nuclear export factor Crm1 (Exportin) and the stress-activated MAP kinase Sty1/Spc1Preprint
Toone, W. M., Kuge, S., Samuels, M., Morgan, B. A., Toda, T., & Jones, N. (1998) · Genes & Development · doi:10.1101/gad.12.10.1453 · Cited by 305 · see citing works
Activation and Regulation of the Spc1 Stress-Activated Protein Kinase in Schizosaccharomyces pombe
Degols, G., Shiozaki, K., & Russell, P. R. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.6.2870 · Cited by 301 · see citing works
The Skn7 response regulator controls gene expression in the oxidative stress response of the budding yeast Saccharomyces cerevisiae
Morgan, B. A., Banks, G. R., Toone, W. M., Raitt, D., Kuge, S., & Johnston, L. H. (1997) · The EMBO Journal · doi:10.1093/emboj/16.5.1035 · Cited by 291 · see citing works
Candida albicans strains heterozygous and homozygous for mutations in mitogen-activated protein kinase signaling components have defects in hyphal development
Köhler, J. R., & Fink, G. R. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.23.13223 · Cited by 283 · see citing works
The molecular defences against reactive oxygen species in yeast
Moradas‐Ferreira, P., Costa, V., Piper, P. W., & Mager, W. H. (1996) · Molecular Microbiology · doi:10.1046/j.1365-2958.1996.403940.x · Cited by 267 · see citing works
The bZip Transcription Factor Cap1p Is Involved in Multidrug Resistance and Oxidative Stress Response in Candida albicans
Alarco, A., & Raymond, M. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.3.700-708.1999 · Cited by 244 · see citing works
Redox signaling and gene control in the Escherichia coli soxRS oxidative stress regulon — a review
Demple, B. (1996) · Gene · doi:10.1016/s0378-1119(96)00329-0 · Cited by 239 · see citing works
Transcriptional activation by the SV40 AP-1 recognition element in yeast is mediated by a factor similar to AP-1 that is distinct from GCN4
Harshman, K., Moye-Rowley, S., & Parker, C. S. (1988) · Cell · doi:10.1016/0092-8674(88)90393-5 · Cited by 239 · see citing works
Saccharomyces cerevisiae has distinct adaptive responses to both hydrogen peroxide and menadione
Jamieson, D. J. (1992) · Journal of Bacteriology · doi:10.1128/jb.174.20.6678-6681.1992 · Cited by 235 · see citing works
Macrophages in resistance to candidiasis
Vázquez‐Torres, A., & Balish, E. (1997) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.61.2.170-192.1997 · Cited by 233 · see citing works
Two Homologous Zinc Finger Genes Identified by Multicopy Suppression in a SNF1 Protein Kinase Mutant of Saccharomyces cerevisiae
Estruch, F., & Carlson, M. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.7.3872-3881.1993 · Cited by 221 · see citing works
Regulation of the Sko1 transcriptional repressor by the Hog1 MAP kinase in response to osmotic stress
Proft, M., Pascual‐Ahuir, A., de Nadal, E., Ariño, J., Serrano, R., & Posas, F. (2001) · The EMBO Journal · doi:10.1093/emboj/20.5.1123 · Cited by 218 · see citing works
Distinct Regulatory Proteins Control the Graded Transcriptional Response to Increasing H2O2 Levels in Fission Yeast Schizosaccharomyces pombe
Quinn, J., Findlay, V. J., Dawson, K., Millar, J. B. A., Jones, N., Morgan, B. A., & Toone, W. M. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-06-0288 · Cited by 209 · see citing works
AP1-mediated Multidrug Resistance in Saccharomyces cerevisiae Requires FLR1 Encoding a Transporter of the Major Facilitator Superfamily
Alarco, A., Balan, I., Talibi, D., Mainville, N., & Raymond, M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.31.19304 · Cited by 206 · see citing works
The role of the YAP1 and YAP2 genes in the regulation of the adaptive oxidative stress responses of Saccharomyces cerevisiae
Stephen, D. W. S., Rivers, S. L., & Jamieson, D. J. (1995) · Molecular Microbiology · doi:10.1111/j.1365-2958.1995.tb02407.x · Cited by 206 · see citing works
The PAR1 (YAP1/SNQ3) gene of Saccharomyces cerevisiae, ac-jun homologue, is involved in oxygen metabolism
Schnell, N. F., Krems, B., & Entian, K. (1992) · Current Genetics · doi:10.1007/bf00351681 · Cited by 205 · see citing works
Cloning and Sequencing of a Candida albicans Catalase Gene and Effects of Disruption of This Gene
Wysong, D. R., Christin, L., Sugar, A. M., Robbins, P. W., & Diamond, R. D. (1998) · Infection and Immunity · doi:10.1128/iai.66.5.1953-1961.1998 · Cited by 201 · see citing works
Identification of cis and trans Components of a Novel Heat Shock Stress Regulatory Pathway in Saccharomyces cerevisiae
Kobayashi, N., & McEntee, K. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.1.248-256.1993 · Cited by 196 · see citing works
Evolution of Osmotic Stress Signaling Via Map Kinase Cascades
Kültz, D., & Burg, M. B. (1998) · Journal of Experimental Biology · doi:10.1242/jeb.201.22.3015 · Cited by 194 · see citing works
Overexpression of a cloned IMP dehydrogenase gene of Candida albicans confers resistance to the specific inhibitor mycophenolic acid
Köhler, G. A., White, T. C., & Agabian, N. (1997) · Journal of Bacteriology · doi:10.1128/jb.179.7.2331-2338.1997 · Cited by 190 · see citing works
Functional Characterization of the MKC1 Gene of Candida albicans , Which Encodes a Mitogen-Activated Protein Kinase Homolog Related to Cell Integrity
Navarro-García, F., Sánchez, M., Plá, J., & Nombela, C. (1995) · Molecular and Cellular Biology · doi:10.1128/mcb.15.4.2197 · Cited by 182 · see citing works
Self-citation
Oxidative killing of Cryptococcus neoformans by human neutrophils. Evidence that fungal mannitol protects by scavenging reactive oxygen intermediates
Chaturvedi, V, Wong, B., & Newman, S. L. (1996) · The Journal of Immunology · doi:10.4049/jimmunol.156.10.3836 · Cited by 180 · cited 1× · see citing works
“Other responses of pathogenic fungi to natural oxidative stress are the blocking of the macrophage oxidative burst in Histoplasma capsulatum (29); the production of polyols, such as mannitol, to scavenge reactive oxygen intermediates in Cryptococcus neoformans (7); and the activation of a TEY-MAP kinase-mediated pathw…”
Background
The mitogen-activated protein kinase homolog HOG1 gene controls glycerol accumulation in the pathogenic fungus Candida albicans
José, C. S., Monge, R. A., Pérez‐Díaz, R. M., Plá, J., & Nombela, C. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.19.5850-5852.1996 · Cited by 180 · see citing works
Self-citation
The Saccharomyces cerevisiae Sko1p transcription factor mediates HOG pathway‐dependent osmotic regulation of a set of genes encoding enzymes implicated in protection from oxidative damage
Rep, M., Proft, M., Remize, F., Tamás, M. J., Serrano, R., Thevelein, J. M., & Hohmann, S. (2001) · Molecular Microbiology · doi:10.1046/j.1365-2958.2001.02384.x · Cited by 179 · see citing works
Discrete Roles of the Spc1 Kinase and the Atf1 Transcription Factor in the UV Response of Schizosaccharomyces pombe
Degols, G., & Russell, P. R. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.6.3356 · Cited by 174 · see citing works
The response regulator-like protein Pos9/Skn7 of Saccharomyces cerevisiae is involved in oxidative stress resistance
Krems, B., Charizanis, C., & Entian, K. (1996) · Current Genetics · doi:10.1007/bf02208613 · Cited by 153 · see citing works
Analysis of the oxidative stress regulation of the Candida albicans transcription factor, Cap1p
Zhang, X., De Micheli, M., Coleman, S. T., Sanglard, D., & Moye‐Rowley, W. S. (2000) · Molecular Microbiology · doi:10.1046/j.1365-2958.2000.01877.x · Cited by 146 · see citing works
Yap1p Activates Gene Transcription in an Oxidant-Specific Fashion
Coleman, S. T., Epping, E. A., Steggerda, S. M., & Moye-Rowley, S. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.12.8302 · Cited by 144 · see citing works
Peroxynitrite contributes to the candidacidal activity of nitric oxide-producing macrophages
Vázquez‐Torres, A., Jones‐Carson, J., & Balish, E. (1996) · Infection and Immunity · doi:10.1128/iai.64.8.3127-3133.1996 · Cited by 137 · see citing works
Multiple modes of activation of the stress‐responsive MAP kinase pathway in fission yeast
Samejima, I., Mackie, S., & Fantes, P. A. (1997) · The EMBO Journal · doi:10.1093/emboj/16.20.6162 · Cited by 134 · see citing works
Yap1p, a yeast transcriptional activator that mediates multidrug resistance, regulates the metabolic stress response.
Gounalaki, N., & Thireos, G. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06720.x · Cited by 131 · see citing works
Cloning, analysis and one-step disruption of the ARG5,6 gene of Candida albicans
Negredo, A., Monteoliva, L., Gil, C., Plá, J., & Nombela, C. (1997) · Microbiology · doi:10.1099/00221287-143-2-297 · Cited by 129 · see citing works
Self-citation
Chlamydospore Formation in Candida albicans Requires the Efg1p Morphogenetic Regulator
Sonneborn, A., Bockmühl, D. P., & Ernst, J. F. (1999) · Infection and Immunity · doi:10.1128/iai.67.10.5514-5517.1999 · Cited by 126 · see citing works
Analysis of the adaptive oxidative stress response ofCandida albicans
Jamieson, D. J., Stephen, D. W. S., & ̈re, E. C. T. (1996) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1996.tb08139.x · Cited by 125 · see citing works
The Saccharomyces cerevisiae sln1p-ssk1p two-component system mediates response to oxidative stress and in an oxidant-specific fashion
Singh, K. K. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00432-9 · Cited by 119 · see citing works
Recent Developments in Molecular Genetics of Candida Albicans
Backer, M. D. D., Magee, P. T., & Plá, J. (2000) · Annual Review of Microbiology · doi:10.1146/annurev.micro.54.1.463 · Cited by 109 · see citing works
Adaptive response of the yeastSaccharomyces cerevisiaeto reactive oxygen species: defences, damage and death
Moradas‐Ferreira, P., & Costa, V. (2000) · Redox Report · doi:10.1179/135100000101535816 · Cited by 105 · see citing works
Overexpression of YAP2, coding for a new yAP protein, and YAP1 in Saccharomyces cerevisiae alleviates growth inhibition caused by 1,10-phenanthroline.
Bossier, P., Fernandes, L., Rocha, D. D., & Rodrigues‐Pousada, C. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)49510-0 · Cited by 82 · see citing works
The roles of glutathione and antioxidant enzymes in menadione-induced oxidative stress
Chiou, T.-J., & Tzeng, W.-F. (2000) · Toxicology · doi:10.1016/s0300-483x(00)00321-8 · Cited by 79 · see citing works
Oxidative Damage to DNA and Its RepairPreprint
Wallace, S. S. (1997) · Cold Spring Harbor Monograph Archive · doi:10.1101/087969502.34.49 · Cited by 61 · see citing works
Flow cytometric analysis of Saccharomyces cerevisiae autolytic mutants and protoplasts
de la Fuente, J. M., Nombela, C., Sánchez, M., & Alvarez, A. M. (1992) · Yeast · doi:10.1002/yea.320080104 · Cited by 51 · see citing works
Self-citation
Cloning of the Candida albicans HIS1 gene by direct complementation of a C. albicans histidine auxotroph using an improved double-ARS shuttle vector
Plá, J., Pérez‐Díaz, R. M., Navarro, F., Sánchez, M., & Nombela, C. (1995) · Gene · doi:10.1016/0378-1119(95)00492-o · Cited by 50 · see citing works
Self-citation
Role of Atfl and Papl in the Induction of the Catalase Gene of Fission Yeast Schizosaccharomyces pombe
Nakagawa, C. W., Yamada, K., & MUTOH, N. (2000) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a022599 · Cited by 46 · see citing works
Fungal infection rates are increasing
Fox, J. L. (1993) · ASM news · Cited by 43 · see citing works
Mitogen‐activated protein kinase Mkp1 of Pneumocystis carinii complements the slt2Δ defect in the cell integrity pathway of Saccharomyces cerevisiae
Fox, D. S., & Smulian, A. G. (1999) · Molecular Microbiology · doi:10.1046/j.1365-2958.1999.01606.x · Cited by 34 · see citing works
The Oxygen Paradox: Biochemistry of Active OxygenPreprint
Hauptmann, N., & Cadenas, E. (1997) · Cold Spring Harbor Monograph Archive · doi:10.1101/087969502.34.1 · Cited by 22 · see citing works
Signal transduction pathways and cell-wall construction in Candida albicans.
Navarro-García, F., Eisman, B., Román, E., Nombela, C., & Pla, J. (2001) · Medical Mycology · doi:10.1080/mmy.39.1.87.100 · Cited by 21 · see citing works
Self-citation
Deactivation of macrophage oxidative burstin vitro by different strains ofHistoplasma capsulatum
Ikeda, T., & Little, J. R. (1995) · Mycopathologia · doi:10.1007/bf01103978 · Cited by 11 · see citing works
1996: A vintage year for yeast and Yeast
Goffeau, A. (1996) · Yeast · doi:10.1002/(sici)1097-0061(199612)12:16 · Cited by 2 · see citing works
Self-citation
Biochemistry, cell biology and molecular biology of lipids ofSaccharomyces cerevisiae
Daum, G., Lees, N. D., Bard, M., & Dickson, R. (1998) · Yeast · doi:10.1002/(sici)1097-0061(199812)14:16

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Selmecki, A., Forche, A., & Berman, J. (2010) · Eukaryotic Cell · doi:10.1128/ec.00060-10 · Cited by 247 · see citing works
Fungicide activity through activation of a fungal signalling pathway
Kojima, K., Takano, Y., Yoshimi, A., Tanaka, C., Kikuchi, T., & Okuno, T. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04244.x · Cited by 243 · see citing works
Antifungal Plant Defensins: Mechanisms of Action and Production
Vriens, K., Cammue, B. P. A., & Thevissen, K. (2014) · Molecules · doi:10.3390/molecules190812280 · Cited by 229 · see citing works
Mechanisms of Resistance to Oxidative and Nitrosative Stress: Implications for Fungal Survival in Mammalian Hosts
Missall, T. A., Lodge, J. K., & McEwen, J. E. (2004) · Eukaryotic Cell · doi:10.1128/ec.3.4.835-846.2004 · Cited by 223 · see citing works
BcSAK1, a Stress-Activated Mitogen-Activated Protein Kinase, Is Involved in Vegetative Differentiation and Pathogenicity in Botrytis cinerea
Segmüller, N., Ellendorff, U., Tudzynski, B., & Tudzynski, P. (2006) · Eukaryotic Cell · doi:10.1128/ec.00153-06 · Cited by 220 · see citing works
Comparative genomics of the environmental stress response in ascomycete fungi
Gasch, A. P. (2007) · Yeast · doi:10.1002/yea.1512 · Cited by 210 · see citing works
Phylogenetic diversity of stress signalling pathways in fungi
Nikolaou, E., Agrafioti, I., Stumpf, M., Quinn, J., Stansfield, I., & Brown, A. J. (2009) · BMC Evolutionary Biology · doi:10.1186/1471-2148-9-44 · Cited by 206 · see citing works
Signalling and oxidant adaptation in Candida albicans and Aspergillus fumigatus
Chauhan, N., Latgé, J., & Calderone, R. (2006) · Nature Reviews Microbiology · doi:10.1038/nrmicro1426 · Cited by 197 · see citing works
Candida morphogenesis and host–pathogen interactions
Whiteway, M. S., & Oberholzer, U. (2004) · Current Opinion in Microbiology · doi:10.1016/j.mib.2004.06.005 · Cited by 196 · see citing works
Glucose Promotes Stress Resistance in the Fungal PathogenCandida albicans
Rodaki, A., Bohovych, I., Enjalbert, B., Young, T., Odds, F. C., Gow, N. A. R., & Brown, A. J. P. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-01-0002 · Cited by 192 · see citing works
Rck1 and Rck2 MAPKAP kinases and the HOG pathway are required for oxidative stress resistance
Bilsland, E., Molin, C., Swaminathan, S., Ramne, A., & Sunnerhagen, P. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2004.04238.x · Cited by 191 · see citing works
Master and Commander in Fungal Pathogens: the Two-Component System and the HOG Signaling Pathway
Bahn, Y. (2008) · Eukaryotic Cell · doi:10.1128/ec.00323-08 · Cited by 175 · see citing works
The metabolic basis of Candida albicans morphogenesis and quorum sensing.
Han, T.-L., Cannon, R. D., & Villas-Bôas, S. G. (2011) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2011.04.002 · Cited by 173 · see citing works
The Sho1 Adaptor Protein Links Oxidative Stress to Morphogenesis and Cell Wall Biosynthesis in the Fungal Pathogen Candida albicans
Román, E., Nombela, C., & Plá, J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.23.10611-10627.2005 · Cited by 173 · see citing works
Self-citation
Nitrosative and oxidative stress responses in fungal pathogenicity
Brown, A. J. P., Haynes, K., & Quinn, J. (2009) · Current Opinion in Microbiology · doi:10.1016/j.mib.2009.06.007 · Cited by 167 · see citing works
The Cek1 and Hog1 Mitogen-Activated Protein Kinases Play Complementary Roles in Cell Wall Biogenesis and Chlamydospore Formation in the Fungal Pathogen Candida albicans
Eisman, B., Alonso-Monge, R., Román, E., Arana, D., Nombela, C., & Pla, J. (2006) · Eukaryotic Cell · doi:10.1128/ec.5.2.347-358.2006 · Cited by 163 · see citing works
Self-citation
Fungal responses to reactive oxygen species
Aguirre, J., Hansberg, W., & Navarro, R. E. (2006) · Medical Mycology · doi:10.1080/13693780600900080 · Cited by 162 · see citing works
Role of reactive oxygen species in fungal cellular differentiations
Scott, B., & Eaton, C. J. (2008) · Current Opinion in Microbiology · doi:10.1016/j.mib.2008.10.008 · Cited by 161 · see citing works
Candida albicansResponse Regulator GeneSSK1Regulates a Subset of Genes Whose Functions Are Associated with Cell Wall Biosynthesis and Adaptation to Oxidative Stress
Chauhan, N., Inglis, D., Roman, E., Pla, J., Li, D., Calera, J. A., & Calderone, R. (2003) · Eukaryotic Cell · doi:10.1128/ec.2.5.1018-1024.2003 · Cited by 159 · see citing works
Comparative genome hybridization reveals widespread aneuploidy in Candida albicans laboratory strains
Selmecki, A., Bergmann, S., & Berman, J. (2005) · Molecular Microbiology · doi:10.1111/j.1365-2958.2005.04492.x · Cited by 157 · see citing works
MAP kinase pathways as regulators of fungal virulence
Román, E., Arana, D. M., Nombela, C., Alonso‐Monge, R., & Plá, J. (2007) · Trends in Microbiology · doi:10.1016/j.tim.2007.02.001 · Cited by 158 · see citing works
Self-citation
Role of the Osmotic Stress Regulatory Pathway in Morphogenesis and Secondary Metabolism in Filamentous Fungi
Duran, R. M., Cary, J. W., & Calvo, A. M. (2010) · Toxins · doi:10.3390/toxins2040367 · Cited by 155 · see citing works
Infection-related gene expression in Candida albicans
Brown, A. J. P., Odds, F. C., & Gow, N. A. R. (2007) · Current Opinion in Microbiology · doi:10.1016/j.mib.2007.04.001 · Cited by 148 · see citing works
Functional analysis of the MAPK pathways in fungi
Martínez‐Soto, D., & Ruíz-Herrera, J. (2017) · Revista Iberoamericana de Micología · doi:10.1016/j.riam.2017.02.006 · Cited by 141 · see citing works
The MAP kinase MpkA controls cell wall integrity, oxidative stress response, gliotoxin production and iron adaptation in Aspergillus fumigatus
Jain, R., Valiante, V., Remme, N., Docimo, T., Heinekamp, T., Hertweck, C., Gershenzon, J., Haas, H., & Brakhage, A. A. (2011) · Molecular Microbiology · doi:10.1111/j.1365-2958.2011.07778.x · Cited by 140 · see citing works
The MAP kinase Mkc1p is activated under different stress conditions in Candida albicans
Navarro-García, F., Eisman, B., Fiuza, S. M., Nombela, C., & Pla, J. (2005) · Microbiology · doi:10.1099/mic.0.28038-0 · Cited by 134 · see citing works
Self-citation
Niche-Specific Activation of the Oxidative Stress Response by the Pathogenic Fungus Candida albicans
Enjalbert, B., MacCallum, D. M., Odds, F. C., & Brown, A. J. P. (2007) · Infection and Immunity · doi:10.1128/iai.01680-06 · Cited by 134 · see citing works
Hsp90 Orchestrates Transcriptional Regulation by Hsf1 and Cell Wall Remodelling by MAPK Signalling during Thermal Adaptation in a Pathogenic Yeast
Leach, M. D., Budge, S., Walker, L. A., Munro, C. A., Cowen, L. E., & Brown, A. J. P. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1003069 · Cited by 133 · see citing works
Remodeling of Global Transcription Patterns of Cryptococcus neoformans Genes Mediated by the Stress-Activated HOG Signaling Pathways
Ko, Y.-J., Yu, Y. M., Kim, G.-B., Lee, G.-W., Maeng, P. J., Kim, S., Floyd, A. M., Heitman, J., & Bahn, Y. (2009) · Eukaryotic Cell · doi:10.1128/ec.00120-09 · Cited by 132 · see citing works
Comparative Phenotypic Analysis of the Major Fungal Pathogens Candida parapsilosis and Candida albicans
Holland, L., Schröder, M., Turner, S. A., Taff, H. T., Andes, D. R., Grózer, Z., Gácser, A., Ames, L., Haynes, K., Higgins, D. G., et al. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004365 · Cited by 132 · see citing works
MgHog1 Regulates Dimorphism and Pathogenicity in the Fungal Wheat Pathogen Mycosphaerella graminicola
Mehrabi, R., Zwiers, L. H., Waard, M. A. D., & Kema, G. H. J. (2006) · Molecular Plant-Microbe Interactions · doi:10.1094/mpmi-19-1262 · Cited by 130 · see citing works
Thioredoxin Regulates Multiple Hydrogen Peroxide-Induced Signaling Pathways in Candida albicans
Dantas, A. D. S., Patterson, M. J., Smith, D. A., MacCallum, D. M., Erwig, L. P., Morgan, B. A., & Quinn, J. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00313-10 · Cited by 126 · see citing works
Identification and Mechanism of Action of the Plant Defensin NaD1 as a New Member of the Antifungal Drug Arsenal against Candida albicans
Hayes, B. M. E., Bleackley, M. R., Wiltshire, J. L., Anderson, M. A., Traven, A., & van der Weerden, N. L. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00365-13 · Cited by 123 · see citing works
The Antimicrobial Peptide Histatin-5 Causes a Spatially Restricted Disruption on the Candida albicans Surface, Allowing Rapid Entry of the Peptide into the Cytoplasm
Mochon, A. B., & Liu, H. (2008) · PLoS Pathogens · doi:10.1371/journal.ppat.1000190 · Cited by 122 · see citing works
A Single MAPKKK Regulates the Hog1 MAPK Pathway in the Pathogenic Fungus Candida albicans
Cheetham, J., Smith, D. A., Dantas, A. D. S., Doris, K. S., Patterson, M. J., Bruce, C. R., & Quinn, J. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-06-0581 · Cited by 120 · see citing works
PiHOG1, a stress regulator MAP kinase from the root endophyte fungus Piriformospora indica, confers salinity stress tolerance in rice plants
Jogawat, A., Vadassery, J., Verma, N., Oelmüller, R., Dua, M., Nevo, E., & Johri, A. K. (2016) · Scientific Reports · doi:10.1038/srep36765 · Cited by 119 · see citing works
A Mitogen-Activated Protein Kinase That Senses Nitrogen Regulates Conidial Germination and Growth in Aspergillus fumigatus
Xue, T., Nguyen, C. K., Romans, A., & May, G. S. (2004) · Eukaryotic Cell · doi:10.1128/ec.3.2.557-560.2004 · Cited by 117 · see citing works
Three Fusarium oxysporum mitogen‐activated protein kinases (MAPKs) have distinct and complementary roles in stress adaptation and cross‐kingdom pathogenicity
Segorbe, D., Pietro, A. D., Pérez‐Nadales, E., & Turrà, D. (2016) · Molecular Plant Pathology · doi:10.1111/mpp.12446 · Cited by 116 · see citing works
Hog1 regulates stress tolerance and virulence in the emerging fungal pathogen Candida auris
Day, A. M., McNiff, M. M., da Silva Dantas, A., Gow, N. A. R., & Quinn, J. (2018) · mSphere · doi:10.1128/msphere.00506-18 · Cited by 116 · see citing works
Differential susceptibility of mitogen-activated protein kinase pathway mutants to oxidative-mediated killing by phagocytes in the fungal pathogen Candida albicans
Arana, D. M., Alonso‐Monge, R., Du, C., Calderone, R., & Plá, J. (2007) · Cellular Microbiology · doi:10.1111/j.1462-5822.2007.00898.x · Cited by 116 · see citing works
Self-citation
Identification of the Candida albicans Cap1p Regulon
Znaidi, S., Barker, K. S., Weber, S., Alarco, A.-M., Liu, T. T., Boucher, G., Rogers, P. D., & Raymond, M. (2009) · Eukaryotic Cell · doi:10.1128/ec.00002-09 · Cited by 115 · see citing works
Msb2 Signaling Mucin Controls Activation of Cek1 Mitogen-Activated Protein Kinase in Candida albicans
Román, E., Cottier, F., Ernst, J. F., & Pla, J. (2009) · Eukaryotic Cell · doi:10.1128/ec.00081-09 · Cited by 113 · see citing works
The role of the sakA ( Hog1 ) and tcsB (s ln1 ) genes in the oxidant adaptation of Aspergillus fumigatus
Du, C., Sarfati, J., Latgé, J. P., & Calderone, R. (2005) · Medical Mycology · doi:10.1080/13693780500338886 · Cited by 113 · see citing works
The Biology of Pichia membranifaciens Killer Toxins
Belda, I., Ruiz, J., Alonso, A., Marquina, D., & Santos, A. (2017) · Toxins · doi:10.3390/toxins9040112 · Cited by 111 · see citing works
A two-component histidine kinase, MoSLN1, is required for cell wall integrity and pathogenicity of the rice blast fungus, Magnaporthe oryzae
Zhang, H., Liu, K., Zhang, X., Song, W., Zhao, Q., Dong, Y., Guo, M., Zheng, X., & Zhang, Z. (2010) · Current Genetics · doi:10.1007/s00294-010-0319-x · Cited by 110 · see citing works
SKN7 of Candida albicans : Mutant Construction and Phenotype Analysis
Singh, P., Chauhan, N., Ghosh, A. K., Dixon, F., & Calderone, R. (2004) · Infection and Immunity · doi:10.1128/iai.72.4.2390-2394.2004 · Cited by 110 · see citing works
Stress Adaptation
Brown, A. J. P., Cowen, L. E., Pietro, A. D., & Quinn, J. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.funk-0048-2016 · Cited by 105 · see citing works
The Hog1 MAP kinase controls respiratory metabolism in the fungal pathogen Candida albicans
Alonso-Monge, R., Carvaihlo, S., Nombela, C., Rial, E., & Pla, J. (2009) · Microbiology · doi:10.1099/mic.0.023309-0 · Cited by 105 · see citing works
Self-citation
Role of the heat shock transcription factor, Hsf1, in a major fungal pathogen that is obligately associated with warm‐blooded animals
Nicholls, S., Leach, M. D., Priest, C. L., & Brown, A. J. P. (2009) · Molecular Microbiology · doi:10.1111/j.1365-2958.2009.06883.x · Cited by 105 · see citing works
Stress signalling to fungal stress-activated protein kinase pathways
Smith, D. A., Morgan, B. A., & Quinn, J. (2010) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2010.01937.x · Cited by 105 · see citing works
Mitochondria Influence CDR1 Efflux Pump Activity, Hog1-Mediated Oxidative Stress Pathway, Iron Homeostasis, and Ergosterol Levels in Candida albicans
Thomas, E., Roman, E., Claypool, S., Manzoor, N., Pla, J., & Panwar, S. L. (2013) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00889-13 · Cited by 105 · see citing works
The Pbs2 MAP kinase kinase is essential for the oxidative-stress response in the fungal pathogen Candida albicans
Arana, D. M., Nombela, C., Alonso‐Monge, R., & Plá, J. (2005) · Microbiology · doi:10.1099/mic.0.27723-0 · Cited by 104 · see citing works
Self-citation
Candida albicans β-Glucan Exposure Is Controlled by the Fungal CEK1 -Mediated Mitogen-Activated Protein Kinase Pathway That Modulates Immune Responses Triggered through Dectin-1
Galán-Díez, M., Arana, D. M., Serrano‐Gómez, D., Kremer, L., Casasnovas, J. M., Ortega, M., Cuesta‐Domínguez, Á., Corbí, A. L., Plá, J., & Fernández‐Ruiz, E. (2010) · Infection and Immunity · doi:10.1128/iai.00989-09 · Cited by 98 · see citing works
The HOG Pathway Is Critical for the Colonization of the Mouse Gastrointestinal Tract by Candida albicans
Prieto, D., Román, E., Correia, I., & Plá, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087128 · Cited by 95 · see citing works
Goa1p of Candida albicans Localizes to the Mitochondria during Stress and Is Required for Mitochondrial Function and Virulence
Bambach, A., Fernandes, M. P., Ghosh, A., Kruppa, M., Alex, D., Li, D., Fonzi, W. A., Chauhan, N., Sun, N., Agrellos, O. A., et al. (2009) · Eukaryotic Cell · doi:10.1128/ec.00066-09 · Cited by 95 · see citing works
Novel Mitogen-Activated Protein Kinase MpkC of Aspergillus fumigatus Is Required for Utilization of Polyalcohol Sugars
Reyes, G. H., Romans, A., Nguyen, C. K., & May, G. S. (2006) · Eukaryotic Cell · doi:10.1128/ec.00178-06 · Cited by 95 · see citing works
Chlamydospore formation in Candida albicans and Candida dubliniensis– an enigmatic developmental programme
Staib, P., & Morschhäuser, J. (2006) · Mycoses · doi:10.1111/j.1439-0507.2006.01308.x · Cited by 94 · see citing works
Activation of stress signalling pathways enhances tolerance of fungi to chemical fungicides and antifungal proteins
Hayes, B. M. E., Anderson, M. A., Traven, A., van der Weerden, N. L., & Bleackley, M. R. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1573-8 · Cited by 93 · see citing works
ThHog1 controls the hyperosmotic stress response in Trichoderma harzianum
Delgado‐Jarana, J., Sousa, S., González, F., Rey, M., & Llobell, A. (2006) · Microbiology · doi:10.1099/mic.0.28729-0 · Cited by 92 · see citing works
Genetic control of chlamydospore formation in Candida albicans
Nobile, C. J., Bruno, V. M., Richard, M. L., Davis, D. A., & Mitchell, A. P. (2003) · Microbiology · doi:10.1099/mic.0.26640-0 · Cited by 89 · see citing works
Integrative Model of Oxidative Stress Adaptation in the Fungal Pathogen Candida albicans
Komalapriya, C., Kaloriti, D., Tillmann, A., Yin, Z., Herrero-de-Dios, C. M., Jacobsen, M. D., Belmonte, R. C., Cameron, G. A., Haynes, K., Grebogi, C., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0137750 · Cited by 88 · see citing works
Histatin 5 Initiates Osmotic Stress Response in Candida albicans via Activation of the Hog1 Mitogen-Activated Protein Kinase Pathway
Vylkova, S., Jang, W. S., Li, W., Nayyar, N., & Edgerton, M. (2007) · Eukaryotic Cell · doi:10.1128/ec.00039-07 · Cited by 88 · see citing works
Mechanisms Underlying the Exquisite Sensitivity of Candida albicans to Combinatorial Cationic and Oxidative Stress That Enhances the Potent Fungicidal Activity of Phagocytes
Kaloriti, D., Jacobsen, M. D., Yin, Z., Patterson, M. J., Tillmann, A., Smith, D. A., Cook, E., You, T., Grimm, M. J., Bohovych, I., et al. (2014) · mBio · doi:10.1128/mbio.01334-14 · Cited by 88 · see citing works
Farnesol signalling in Candida albicans – more than just communication
Polke, M., Leonhardt, I., Kurzai, O., & Jacobsen, I. D. (2017) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2017.1337711 · Cited by 87 · see citing works
Combinatorial stresses kill pathogenicCandidaspecies
Kaloriti, D., Tillmann, A., Cook, E., Jacobsen, M., You, T., Lenardon, M., Ames, L., Barahona, M., Chandrasekaran, K., Coghill, G., et al. (2012) · Medical Mycology · doi:10.3109/13693786.2012.672770 · Cited by 86 · see citing works
The mitogen-activated protein kinase gene, VdHog1, regulates osmotic stress response, microsclerotia formation and virulence in Verticillium dahliae
Wang, Y., Tian, L., Xiong, D., Klosterman, S. J., Xiao, S., & Tian, C. (2016) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2016.01.011 · Cited by 84 · see citing works
Two-component signal transduction in human fungal pathogens
Kruppa, M., & Calderone, R. (2006) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2006.00024.x · Cited by 84 · see citing works
Different toxicity of anatase and rutile TiO 2 nanoparticles on macrophages: Involvement of difference in affinity to proteins and phospholipids
Yu, Q., Wang, H., Peng, Q., Li, Y., Liu, Z., & Li, M. (2017) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2017.04.026 · Cited by 81 · see citing works
The serine/threonine protein phosphatase SIT4 modulates yeast‐to‐hypha morphogenesis and virulence in Candida albicans
Lee, C., Nantel, A., Jiang, L., Whiteway, M. S., & Shen, S. (2004) · Molecular Microbiology · doi:10.1111/j.1365-2958.2003.03879.x · Cited by 79 · see citing works
The high osmolarity glycerol (HOG) pathway in fungi †
Yaakoub, H., Sanchez, N. S., Ongay-Larios, L., Courdavault, V., Calenda, A., Bouchara, J.-P., Coria, R., & Papon, N. (2021) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2021.2011834 · Cited by 77 · see citing works
Chlamydospore Formation during Hyphal Growth in Cryptococcus neoformans
Lin, X., & Heitman, J. (2005) · Eukaryotic Cell · doi:10.1128/ec.4.10.1746-1754.2005 · Cited by 77 · see citing works
MaHog1, a Hog1-type mitogen-activated protein kinase gene, contributes to stress tolerance and virulence of the entomopathogenic fungus Metarhizium acridum
Jin, K., Ming, Y., & Xia, Y. X. (2012) · Microbiology · doi:10.1099/mic.0.059469-0 · Cited by 76 · see citing works
The HOG MAPK pathway in Candida albicans: more than an osmosensing pathway
Román, E., Correia, I., Prieto, D., Alonso‐Monge, R., & Plá, J. (2019) · International Microbiology · doi:10.1007/s10123-019-00069-1 · Cited by 73 · see citing works
Self-citation
The Cek1 MAPK is a short-lived protein regulated by quorum sensing in the fungal pathogenCandida albicans
Román, E., Alonso‐Monge, R., Gong, Q., Li, D., Calderone, R., & Plá, J. (2009) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2009.00545.x · Cited by 70 · see citing works
Self-citation
Low virulent strains of Candida albicans: Unravelling the antigens for a future vaccine
Fernández‐Arenas, E., Molero, G., Nombela, C., Diez‐Orejas, R., & Gil, C. (2004) · PROTEOMICS · doi:10.1002/pmic.200400929 · Cited by 69 · see citing works
Self-citation
Stress-Activated Protein Kinases in Human Fungal Pathogens
Day, A. M., & Quinn, J. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00261 · Cited by 68 · see citing works
A MAPK gene from Dead Sea fungus confers stress tolerance to lithium salt and freezing–thawing: Prospects for saline agriculture
Jin, Y., Weining, S., & Nevo, E. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509653102 · Cited by 68 · see citing works
Disruption ofSRM1, a mitogen-activated protein kinase gene, affects sensitivity to osmotic and ultraviolet stressors in the phytopathogenic fungusBipolaris oryzae
Moriwaki, A., Kubo, E., Arase, S., & Kihara, J. (2006) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2006.00178.x · Cited by 67 · see citing works
Cell Cycle Dynamics and Quorum Sensing in Candida albicans Chlamydospores Are Distinct from Budding and Hyphal Growth
Martin, S. W., Douglas, L. M., & Konopka, J. B. (2005) · Eukaryotic Cell · doi:10.1128/ec.4.7.1191-1202.2005 · Cited by 66 · see citing works
Sophorolipid exhibits antifungal activity by ROS mediated endoplasmic reticulum stress and mitochondrial dysfunction pathways in Candida albicans
Haque, F., Verma, N. K., Alfatah, M., Bijlani, S., & Bhattacharyya, M. S. (2019) · RSC Advances · doi:10.1039/c9ra07599b · Cited by 65 · see citing works
Role of Heat Shock Transcription Factor in Saccharomyces cerevisiae Oxidative Stress Response
Yamamoto, A., Ueda, J., Yamamoto, N., Hashikawa, N., & Sakurai, H. (2007) · Eukaryotic Cell · doi:10.1128/ec.00098-07 · Cited by 64 · see citing works
Oxidative stress in yeast
Lushchak, V. I. (2010) · Biochemistry (Moscow) · doi:10.1134/s0006297910030041 · Cited by 64 · see citing works
High-Resolution SNP/CGH Microarrays Reveal the Accumulation of Loss of Heterozygosity in Commonly UsedCandida albicansStrains
Abbey, D., Hickman, M. A., Gresham, D., & Berman, J. G. (2011) · G3 Genes Genomes Genetics · doi:10.1534/g3.111.000885 · Cited by 64 · see citing works
Fungi sensing environmental stress
Alonso‐Monge, R., Román, E., Arana, D. M., Plá, J., & Nombela, C. (2009) · Clinical Microbiology and Infection · doi:10.1111/j.1469-0691.2008.02690.x · Cited by 62 · see citing works
Self-citation
A proteomic analysis of the salt, cadmium and peroxide stress responses in Candida albicans and the role of the Hog1 stress‐activated MAPK in regulating the stress‐induced proteome
Yin, Z., Stead, D., Walker, J., Selway, L., Smith, D. A., Brown, A. J. P., & Quinn, J. (2009) · PROTEOMICS · doi:10.1002/pmic.200800958 · Cited by 62 · see citing works
The Sko1 protein represses the yeast-to-hypha transition and regulates the oxidative stress response in Candida albicans
Alonso‐Monge, R., Román, E., Arana, D. M., Prieto, D., Urrialde, V., Nombela, C., & Plá, J. (2010) · Fungal Genetics and Biology · doi:10.1016/j.fgb.2010.03.009 · Cited by 62 · see citing works
Self-citation
Regulation of Yeast-to-Hyphae Transition in Yarrowia lipolytica
Pomraning, K., Bredeweg, E., Kerkhoven, E. J., Barry, K., Haridas, S., Hundley, H. N., LaButti, K. M., Lipzen, A., Yan, M., Magnuson, J. K., et al. (2018) · mSphere · doi:10.1128/msphere.00541-18 · Cited by 59 · see citing works

The Cek1 and Hog1 Mitogen-Activated Protein Kinases Play Complementary Roles in Cell Wall Biogenesis and Chlamydospore Formation in the Fungal Pathogen Candida albicans
Eisman, B., Alonso-Monge, R., Román, E., Arana, D., Nombela, C., & Pla, J. (2006) · Eukaryotic Cell · doi:10.1128/ec.5.2.347-358.2006 · Cited by 163 · see citing works
Self-citation
Adaptive tolerance to oxidative stress and the induction of antioxidant enzymatic activities in Candida albicans are independent of the Hog1 and Cap1-mediated pathways
Párraga, P. G., Alonso‐Monge, R., Plá, J., & Argüelles, J. C. (2010) · FEMS Yeast Research · doi:10.1111/j.1567-1364.2010.00654.x · Cited by 37 · see citing works
Self-citation
The Hog1 MAP Kinase Promotes the Recovery from Cell Cycle Arrest Induced by Hydrogen Peroxide in Candida albicans
Correia, I., Alonso‐Monge, R., & Plá, J. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.02133 · Cited by 28 · see citing works
Self-citation
Characterization of a Candida albicans Mutant Defective in All MAPKs Highlights the Major Role of Hog1 in the MAPK Signaling Network
Correia, I., Wilson, D., Hube, B., & Plá, J. (2020) · Journal of Fungi · doi:10.3390/jof6040230 · Cited by 23 · see citing works
The Hog1 MAP kinase controls respiratory metabolism in the fungal pathogen Candida albicans
Alonso-Monge, R., Carvaihlo, S., Nombela, C., Rial, E., & Pla, J. (2009) · Microbiology · doi:10.1099/mic.0.023309-0 · Cited by 105 · see citing works
Self-citation

Authors: Alonso-Monge, R., Navarro-García, F., Román, E., Negredo, A. I., Eisman, B., Nombela, C., & Pla, J.
Affiliations: Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, E-28040 Madrid, Spain
Universidad Complutense de Madrid (ES)
Venue: Eukaryotic Cell
Publisher: American Society for Microbiology
Published: 2003-04
Volume: 2
Issue: 2
Pages: 351-361
ISSN: 1535-9778 (ISSN-L)
1535-9786
DOI: 10.1128/ec.2.2.351-361.2003
PMC: PMC154845
OpenAlex: W2146807721
Cited by: 308
References: 73
Citations by year: 2026: 8 · 2025: 13 · 2024: 10 · 2023: 8 · 2022: 7 · 2021: 9 · 2020: 12 · 2019: 10 · 2018: 15 · 2017: 22 · 2016: 15 · 2015: 11 · 2014: 18 · 2013: 12 · 2012: 11
FWCI: 6.56
Type: journal article
Language: en
Open access: diamond
doi.org
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Eukaryotic Cell (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Ministerio de Ciencia y Tecnología
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Infectious Diseases › Antifungal resistance and susceptibility
Keywords: Hog1 MAP kinase, Candida albicans, oxidative stress response, chlamydospore formation, hydrogen peroxide, reactive oxygen species, EFG1, fungal pathogenicity, cell death
MeSH terms: Candida albicans, Cell Nucleus, Cells, Cultured, Fungal Proteins, Mutation, Osmolar Concentration, Phosphorylation, Spores, Fungal, Ultraviolet Rays, Organelles, Oxidants, Cell Death, Reactive Oxygen Species, Oxidative Stress, Cell Cycle Proteins, Mitogen-Activated Protein Kinases, MAP Kinase Signaling System, Saccharomyces cerevisiae Proteins, Basic-Leucine Zipper Transcription Factors

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The Hog1 Mitogen-Activated Protein Kinase Is Essential in the Oxidative Stress Response and Chlamydospore Formation in Candidaalbicans

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