The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Diversity of CRISPR loci in Escherichia coli
Abstract
CRISPR (clustered regularly interspaced short palindromic repeats) and CAS (CRISPR-associated sequence) proteins are constituents of a novel genetic barrier that limits horizontal gene transfer in prokaryotes by means of an uncharacterized mechanism. The fundamental discovery of small RNAs as the guides of the defence apparatus arose as a result of Escherichia coli studies. However, a survey of the system diversity in this species in order to further contribute to the understanding of the CRISPR mode of action has not yet been performed. Here we describe two CRISPR/CAS systems found in E. coli, following the analysis of 100 strains representative of the species' diversity. Our results substantiate different levels of activity between loci of both CRISPR types, as well as different target preferences and CRISPR relevances for particular groups of strains. Interestingly, the data suggest that the degeneration of one CRISPR/CAS system in E. coli ancestors could have been brought about by self-interference.
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Cites
The Link between Phylogeny and Virulence in Escherichia coli Extraintestinal Infection
Picard, B., Garcia, J. S., Gouriou, S., Duriez, P., Brahimi, N., Bingen, E., Elion, J., & Denamur, E. (1999) · Infection and Immunity · doi:10.1128/iai.67.2.546-553.1999 · Cited by 794
Cited by
Antibiotic resistance in microbes: History, mechanisms, therapeutic strategies and future prospects
Uddin, T. M., Chakraborty, A. J., Khusro, A., Zidan, B. R. M., Mitra, S., Emran, T. B., Dhama, K., Ripon, M. K. H., Gajdács, M., Sahibzada, M. U. K., et al. (2021) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2021.10.020 · Cited by 1,311
CRISPR-Cas Systems in Bacteria and Archaea: Versatile Small RNAs for Adaptive Defense and Regulation
Bhaya, D., Davison, M., & Barrangou, R. (2011) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132430 · Cited by 914
CRISPR-mediated adaptive immune systems in bacteria and archaea
Sorek, R., Lawrence, C. M., & Wiedenheft, B. (2013) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-072911-172315 · Cited by 668
Proteins and DNA elements essential for the CRISPR adaptation process in Escherichia coli
Yosef, I., Goren, M. G., & Qimron, U. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks216 · Cited by 655
Molecular memory of prior infections activates the CRISPR/Cas adaptive bacterial immunity system
Datsenko, K. A., Pougach, K., Tikhonov, A., Wanner, B. L., Severinov, K., & Semenova, E. (2012) · Nature Communications · doi:10.1038/ncomms1937 · Cited by 561
Metadata
- Authors
- Díez-Villaseñor, C., Almendros, C., García-Martínez, J., & Mojica, F. J. M.
- Venue
- Microbiology
- Publisher
- Microbiology Society
- Published
- 2010-05-01
- Volume
- 156
- Issue
- 5
- Pages
- 1351-1361
- ISSN
- 1350-0872 (ISSN-L)
- 1465-2080
- OpenAlex
- W2022480099
- Cited by
- 194
- References
- 1
- FWCI
- 8.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Díez-Villaseñor, C., Almendros, C., García-Martínez, J., & Mojica, F. J. M. (2010). Diversity of CRISPR loci in Escherichia coli. Microbiology. https://doi.org/10.1099/mic.0.036046-0
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