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Muscle Wasting and Resistance of Muscle Anabolism: The “Anabolic Threshold Concept” for Adapted Nutritional Strategies during Sarcopenia
Open accessAbstract
Skeletal muscle loss is observed in several physiopathological situations. Strategies to prevent, slow down, or increase recovery of muscle have already been tested. Besides exercise, nutrition, and more particularly protein nutrition based on increased amino acid, leucine or the quality of protein intake has generated positive acute postprandial effect on muscle protein anabolism. However, on the long term, these nutritional strategies have often failed in improving muscle mass even if given for long periods of time in both humans and rodent models. Muscle mass loss situations have been often correlated to a resistance of muscle protein anabolism to food intake which may be explained by an increase of the anabolic threshold toward the stimulatory effect of amino acids. In this paper, we will emphasize how this anabolic resistance may affect the intensity and the duration of the muscle anabolic response at the postprandial state and how it may explain the negative results obtained on the long term in the prevention of muscle mass. Sarcopenia, the muscle mass loss observed during aging, has been chosen to illustrate this concept but it may be kept in mind that it could be extended to any other catabolic states or recovery situations.
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“Protein, amino acid, and peptides supplementation (Table 1) is considered to be effective in increasing muscle anabolism and preventing muscle atrophy during extended periods of immobilization [19].”
From Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy (2021) · cites this paper as [19]
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Cites
Associations of elevated interleukin-6 and C-reactive protein levels with mortality in the elderly
Harris, T. B., Ferrucci, L., Tracy, R. P., Corti, M. C., Wacholder, S., Ettinger, W. H., Heimovitz, H., Cohen, H. J., & Wallace, R. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00066-2 · Cited by 1,488
Slow and fast dietary proteins differently modulate postprandial protein accretion
Boirie, Y., Dangin, M., Gachon, P., Vasson, M.-P., Maubois, J.-L., & Beaufrère, B. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.26.14930 · Cited by 1,453
Visser, M., Pahor, M., Taaffe, D. R., Goodpaster, B. H., Simonsick, E. M., Newman, A. B., Nevitt, M., & Harris, T. B. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.5.m326 · Cited by 1,294
Inflammatory markers and loss of muscle mass (sarcopenia) and strength
Schaap, L. A., Pluijm, S. M. F., Deeg, D. J. H., & Visser, M. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.10.049 · Cited by 1,047
Katsanos, C. S., Kobayashi, H., Sheffield-Moore, M., Aarsland, A., & Wolfe, R. R. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00488.2005 · Cited by 923
Smith, G. I., Atherton, P., Reeds, D. N., Mohammed, B. S., Rankin, D., Rennie, M. J., & Mittendorfer, B. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.005611 · Cited by 665
Rennie, M. J., Edwards, R. H. T., Halliday, D., Matthews, D. E., Wolman, S. L., & Millward, D. J. (1982) · Clinical Science · doi:10.1042/cs0630519 · Cited by 455
Influence of the Protein Digestion Rate on Protein Turnover in Young and Elderly Subjects
Dangin, M., Boirie, Y., Guillet, C., & Beaufrère, B. (2002) · The Journal of Nutrition · doi:10.1093/jn/131.10.3228s · Cited by 312
Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men.
Verhoeven, S., Vanschoonbeek, K., Verdijk, L., Koopman, R., Wodzig, W., Dendale, P., & van Loon, L. V. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26668 · Cited by 286
Protein pulse feeding improves protein retention in elderly women
Arnal, M.-A., Mosoni, L., Boirie, Y., Houlier, M.-L., Morin, L., Verdier, E., Ritz, P., Antoine, J.-M., Prugnaud, J., Beaufrère, B., et al. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.6.1202 · Cited by 284
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Research works printed but not linked: 3
- 1996, American Journal of Physiology, 271, E1083
- 2000, American Journal of Physiology, 278, E902
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Items 101–152 of 152
Verney, J., Martin, V., Ratel, S., Chavanelle, V., Bargetto, M., Etienne, M., Chaplais, E., Ruyet, P. L., Bonhomme, C., Combaret, L., et al. (2016) · The journal of nutrition health & aging · doi:10.1007/s12603-016-0855-2 · Cited by 6
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Benito‐Vázquez, I., Muñoz-Labrador, A. M., Garrido‐Romero, M., Hontoria-Caballo, G., García-García, C., Díez‐Municio, M., & Moreno, F. J. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251910315 · Cited by 5
Assad-Bustillos, M., Féron, G., & Valle, G. D. (2022) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2021.11.003 · Cited by 5
Cereal Grain-Based Milks and Their Potential Health Properties
Srikaeo, K. (2022) · Springer eBooks · doi:10.1007/978-3-031-05611-6_10 · Cited by 6
Nutrition, Protein Turnover and Muscle Mass
Walrand, S., Guillet, C., & Boirie, Y. (2012) · Wiley eBooks · doi:10.1002/9781118338032.ch5 · Cited by 4
Sadri, S., Sharifi, G., & Dehkordi, K. J. (2021) · Sport Sciences for Health · doi:10.1007/s11332-021-00828-6 · Cited by 4
Amino Acid and Protein Metabolism in Pulmonary Diseases and Nutritional Abnormalities
Barreiro, E., & Gea, J. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802167-5.00012-8 · Cited by 4
Nutrition, Protein Turnover and Muscle Mass
Walrand, S., Guillet, C., & Boirie, Y. (2021) · Wiley eBooks · doi:10.1002/9781119597896.ch5 · Cited by 5
Salles, J., Gueugneau, M., Laleg, K., Giraudet, C., Sanchez, P., Blot, A., Richard, R., Neveux, N., Lefranc‐Millot, C., Perreau, C., et al. (2024) · Nutrients · doi:10.3390/nu16172870 · Cited by 5
Dimina, L., Landais, J., Mathé, V., Jarzaguet, M., Bourgot, C. L., Hermier, D., Mariotti, F., Rémond, D., & Mosoni, L. (2023) · Journal of Nutrition · doi:10.1016/j.tjnut.2023.01.025 · Cited by 4
Schnebelen, C., Baudry, C., Clerc, E., Jaruga, A., Ruyet, P. L., & Lecerf, J. (2015) · Nutrition and Aging · doi:10.3233/nua-150056 · Cited by 3
Leucine-Protein Functional Adaptation in the Clinical Setting
Karagounis, L. G., Hugues, M., & ROWLANDS, D. S. (2014) · Springer eBooks · doi:10.1007/978-1-4939-1914-7_17 · Cited by 3
Whey Protein and Muscle Protection
Boirie, Y. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-810422-4.00015-4 · Cited by 3
Les protéines de la viande, intérêt pour la nutrition des seniors
Rémond, D. (2019) · Médecine des Maladies Métaboliques · doi:10.1016/s1957-2557(19)30070-7 · Cited by 3
Tesseraud, S., Bouvarel, I., Fraysse, P., Métayer-Coustard, S., Collin, A., Lessire, M., & Berri, C. (2014) · INRAE Productions Animales · doi:10.20870/productions-animales.2014.27.5.3081 · Cited by 2
Decreased serum creatinine to cystatin C ratio is associated with low tongue pressure
Komorita, Y., Ide, H., Yoshinari, M., Ohta, Y., Nakamichi, I., Fujisawa, R., Fujii, W., & Fukuhara, M. (2023) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/ggi.14780 · Cited by 1
Hiraoka, A., Ohama, H., Tada, F., Kimura, Y., Nakamura, A., Murakawa, K., Matsuda, T., Matsuoka, K., Kato, K., Onishi, K., et al. (2025) · Hepatology Research · doi:10.1111/hepr.70002 · Cited by 2
Dieuleveut, C., Favrelière, C., & Favreau, L. (2016) · Nutrition Clinique et Métabolisme · doi:10.1016/j.nupar.2016.03.001 · Cited by 2
Protein Metabolism in the Elderly
Dillon, E. L. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802167-5.00007-4 · Cited by 3
Mosoni, L., Jarzaguet, M., David, J., Polakof, S., Savary‐Auzeloux, I., Rémond, D., & Dardevet, D. P. (2019) · Nutrients · doi:10.3390/nu11040727 · Cited by 2
Curiel-Cervantes, V. (2026) · Physiologia · doi:10.3390/physiologia6010005 · Cited by 1
Nutritional Recommendations for the Young and Aging Females
Ziemba, A. M., Curry, E. J., Gong, J., & Matzkin, E. (2013) · Springer eBooks · doi:10.1007/978-1-4471-4712-1_2 · Cited by 1
Le métabolisme protéique musculaire, contrôle nutritionnel
Mosoni, L. (2014) · Nutrition Clinique et Métabolisme · doi:10.1016/j.nupar.2013.12.003 · Cited by 1
Leblanc, A. L., & Guilbot, A. (2014) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2014.10.001 · Cited by 1
Brazilian Journal of Health Review
(2021) · doi:10.34119/2595-6825 · Cited by 1
Churchward‐Venne, T. A. (2013) · MacSphere (McMaster University) · doi:10.71548/9052
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Weijs, P. J. M. (2014)
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Ådnanes, S. (2015) · NORA - Norwegian Open Research Archives
Protein Metabolism and Requirement in Intensive Care Units and Septic Patients
Weijs, P. J. M. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802167-5.00010-4
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Romanelli, F., Sansone, M., Lenzi, A., & Luigi, L. D. (2016) · L Endocrinologo · doi:10.1007/s40619-016-0210-1
High Protein for All is it Currently a State of Art in Critical Care Nutrition?
(2016) · Journal of Anesthesia & Critical Care Open Access · doi:10.15406/jaccoa.2016.06.00213
Crocco, P., Iannone, F., Dato, S., Rose, G., & Passarino, G. (2021) · Elsevier eBooks · doi:10.1016/c2019-0-04856-x
Dardevet, D. P., Mosoni, L., Savary‐Auzeloux, I., Peyron, M., Polakof, S., & Rémond, D. (2021) · Cahiers de Nutrition et de Diététique · doi:10.1016/j.cnd.2021.10.002 · Cited by 2
Knight, A. (2022) · Digital Archive @ GSU · doi:10.57709/4326463
Thissen, J. (2016) · Springer eBooks · doi:10.1007/978-3-319-27687-8_5
Gioia, G., Molfino, A., Fanelli, F. R., & Muscaritoli, M. (2017) · doi:10.1093/med/9780198701590.003.0063
Different components of frailty in the aging subjects—The role of sarcopenia
Crocco, P., Dato, S., Iannone, F., Passarino, G., & Rose, G. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822569-1.00011-1
The contribution of meat in the diet of senior citizens
Rémond, D. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85125-1.00070-3 · Cited by 1
Giron, M., Thomas, M., Jarzaguet, M., Mayeur, C., Ferrere, G., Noordine, M.-L., Bornes, S., Dardevet, D. P., Chassard, C., & Savary‐Auzeloux, I. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1109835 · Cited by 1
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Kaya, O. (2023) · Akademisyen Kitabevi eBooks · doi:10.37609/akya.2575
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Mahmoo, A. (2025) · Premier Journal of Sports Science · doi:10.70389/pjsps.100008
Chen, Y., Xu, J., Pu, Y., Liu, D., Du, Q., Fumpa, M., Widjaja, J., Wan, Q., Cheng, Z., & Chen, Y. (2026) · Obesity Surgery · doi:10.1007/s11695-025-08424-0
Zhuang, S.-R., Yen, C., Lin, K.-Y., & Shen, Y. (2026) · Nutrients · doi:10.3390/nu18030504
Assad-Bustillos, M. (2019) · theses.fr (ABES) · doi:10.70675/14357a02zc588z4907zacc6zac6d2dd4f623 · Cited by 1
Hiraoka, A., Ohama, H., Tada, F., Tange, K., Yoshida, O., Hirooka, M., Abe, M., Ninomiya, T., Yoshio, S., & Hiasa, Y. (2026) · Hepatology Research · doi:10.1111/hepr.70245
Sobejana, M. M., Korpershoek, R. M., Steinz, M. M., van der Laken, C. J., van der Leeden, M., Jaspers, R. T., Visser, B., van der Esch, M., Meskers, C. G. M., & de Rooij, M. (2026) · PLoS ONE · doi:10.1371/journal.pone.0356181
Reyes, J. M., Hajj‐Boutros, G., Rouabhia, D., Morais, J., Salech, F., & Duque, G. (2026) · Experimental Physiology · doi:10.1113/ep093790
Metadata
- Authors
- Dardevet, D., Rémond, D., Peyron, M.-A., Papet, I., Savary-Auzeloux, I., & Mosoni, L.
- Affiliations
- Université Clermont Auvergne (FR)
- Clermont Université and Unité de Nutrition Humaine, Université d'Auvergne, BP 10448, 63000 Clermont-Ferrand, France
- Corresponding author
- Dardevet, Dominique
- Venue
- The Scientific World JOURNAL
- Publisher
- Hindawi Limited
- Published
- 2012
- Volume
- 2012
- Pages
- 1-6
- ISSN
- 1537-744X (ISSN-L)
- PMC
- PMC3541599
- OpenAlex
- W2063299372
- Cited by
- 153
- References
- 38
- Citations by year
- 2026: 6 · 2025: 2 · 2024: 4 · 2023: 6 · 2022: 20 · 2021: 10 · 2020: 16 · 2019: 12 · 2018: 19 · 2017: 12 · 2016: 11 · 2015: 9 · 2014: 17 · 2013: 8 · 2012: 1
- FWCI
- 1.03
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- The Scientific World JOURNAL (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- HAL (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Keywords
- sarcopenia, muscle atrophy, muscle protein anabolism, anabolic resistance, protein nutrition, amino acids, leucine, muscle mass loss, aging, nutritional strategies
- MeSH terms
- Humans, Muscle, Skeletal, Sarcopenia
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