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The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes
Open accessAbstract
Since December 2019, a newly identified coronavirus (2019 novel coronavirus, 2019-nCov) is causing outbreak of pneumonia in one of largest cities, Wuhan, in Hubei province of China and has draw significant public health attention. The same as severe acute respiratory syndrome coronavirus (SARS-CoV), 2019-nCov enters into host cells via cell receptor angiotensin converting enzyme II (ACE2). In order to dissect the ACE2-expressing cell composition and proportion and explore a potential route of the 2019-nCov infection in digestive system infection, 4 datasets with single-cell transcriptomes of lung, esophagus, gastric, ileum and colon were analyzed. The data showed that ACE2 was not only highly expressed in the lung AT2 cells, esophagus upper and stratified epithelial cells but also in absorptive enterocytes from ileum and colon. These results indicated along with respiratory systems, digestive system is a potential routes for 2019-nCov infection. In conclusion, this study has provided the bioinformatics evidence of the potential route for infection of 2019-nCov in digestive system along with respiratory tract and may have significant impact for our healthy policy setting regards to prevention of 2019-nCoV infection.
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“High ACE2 expression was identified in type II alveolar cells (AT2) of lung10–12, esophagus upper and stratified epithelial cells, absorptive enterocytes from ileum and colon12, cholangiocytes13, myocardial cells, kidney proximal tubule cells, and bladder urothelial cells10.”
From High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa (2020) · cites this paper as [12]
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Atlas of ACE2 gene expression in mammals reveals novel insights in transmisson of SARS-Cov-2Preprint
Sun, K., Gu, L., Ma, L., & Duan, Y. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.03.30.015644 · Cited by 38
Adhikari, S. P., Sha, M., Wu, Y., Mao, Y., Ye, R., Wang, Q., Sun, C., Sylvia, S., Rozelle, S., Raat, H., et al. (2020) · doi:10.21203/rs.2.24474/v1 · Cited by 43
Are Older People Really More Susceptible to SARS-CoV-2?
Zhang, S., Yang, Z., Li, Z.-N., Chen, Z.-L., Yue, S.-J., Fu, R.-J., Xu, D.-Q., Zhang, S., & Tang, Y.-P. (2022) · Aging and disease · doi:10.14336/ad.2022.0130 · Cited by 39
“In addition to AET2 cells, ACE2 is also highly expressed in epithelial cells of the esophagus, ileum and colon, so the digestive tract may be a potential route for SARS-CoV-2 infection [16].”
BackgroundSelf-citationOberemok, V. V., Laikova, K. V., Yurchenko, K. A., Фомочкина, И. И., & Kubyshkin, A. V. (2020) · Inflammation Research · doi:10.1007/s00011-020-01352-y · Cited by 39
Gastrointestinal predictors of severe COVID-19: systematic review and meta-analysis
Aziz, M. (2020) · Annals of Gastroenterology · doi:10.20524/aog.2020.0527 · Cited by 39
Inchingolo, A. D., Inchingolo, A. M., Bordea, I. R., Malcangi, G., Xhajanka, E., Scarano, A., Lorusso, F., Farronato, M., Tartaglia, G. M., Isacco, C. G., et al. (2021) · Microorganisms · doi:10.3390/microorganisms9040793 · Cited by 43
Vocal Disorders in Patients with COVID 19 in Egypt
Azzam, A. A. A., Samy, A., Sefein, I. K., & Elrouby, I. M. (2021) · Indian Journal of Otolaryngology and Head & Neck Surgery · doi:10.1007/s12070-021-02663-0 · Cited by 39
Raghavan, K., Dedeepiya, V. D., Vaddi, S., Rao, K. S. J., Ikewaki, N., Sonoda, T., Levy, G. A., Iwasaki, M., Senthilkumar, R., Preethy, S., et al. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112243 · Cited by 39
Structure of dimeric full-length human ACE2 in complex with B 0 AT1Preprint
Yan, R., Zhang, Y., Li, Y., Xia, L., & Zhou, Q. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.17.951848 · Cited by 39
A Correlation Analysis Between the Nutritional Status and Prognosis of COVID-19 Patients
Zhou, J., Ma, Y., Liu, Y., Xiang, Y., Tao, C. Z., Yu, H., & Huang, J. (2020) · The journal of nutrition health & aging · doi:10.1007/s12603-020-1457-6 · Cited by 40
Premises among SARS-CoV-2, dysbiosis and diarrhea: Walking through the ACE2/mTOR/autophagy route
de Oliveira, A. P., Lopes, A. L. F., Pacheco, G., Nolêto, I. R. D. S. G., Nicolau, L. A. D., & Medeiros, J. V. R. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.110243 · Cited by 38
Molecular screening of glycyrrhizin-based inhibitors against ACE2 host receptor of SARS-CoV-2
Ahmad, S., Waheed, Y., Abro, A., Abbasi, S. W., & Ismail, S. (2021) · Journal of Molecular Modeling · doi:10.1007/s00894-021-04816-y · Cited by 39
Uncommon presentation of COVID-19: Gastrointestinal bleeding
Gülen, M., & Satar, S. (2020) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2020.05.001 · Cited by 37
COVID-19 Is a Multi-Organ Aggressor: Epigenetic and Clinical Marks
Kgatle, M., Lawal, I. O., Mashabela, G. T., Boshomane, T. M. G., Koatale, P. C., Mahasha, P. W., Ndlovu, H., Vorster, M., Rodrigues, H. G., Zeevaart, J. R., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.752380 · Cited by 37
Coronavirus disease 2019: A new severe acute respiratory syndrome from Wuhan in China
Cao, Y., Cai, K., & XIONG, L. (2020) · Acta Virologica · doi:10.4149/av_2020_201 · Cited by 36
Metadata
- Authors
- Zhang, H., Kang, Z., Gong, H., Xu, D., Wang, J., Li, Z., Cui, X., Xiao, J., Meng, T., Zhou, W., Liu, J., & Xu, H.
- Affiliations
- Second Military Medical University (CN)
- Tongji University (CN)
- Center for Life Sciences (CN)
- Corresponding author
- Meng, Tong
- Zhou, Wang
- Liu, Jianmin
- Xu, Huji
- ORCID
- Venue
- bioRxiv (Cold Spring Harbor Laboratory)
- Publisher
- openRxiv
- Published
- 2020-01-31
- OpenAlex
- W3004151654
- Cited by
- 658
- References
- 38
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 39 · 2023: 31 · 2022: 46 · 2021: 154 · 2020: 384
- Type
- posted content
- Language
- en
- Open access
- green
- doi.org
- Licence
- Locations
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
- Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Keywords
- SARS-CoV-2, ACE2 receptor, gastrointestinal infections, enterocytes, intestinal epithelium, esophageal epithelium, single-cell transcriptomics, infection route, COVID-19 prevention
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