PreprintCited by 658SARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research StudiesSingle-cell and spatial transcriptomics

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The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes

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Zhang, Hao, Kang, Zijian, Gong, Haiyi, Xu, Da, Wang, Jing, Li, Zifu, Cui, Xingang, Xiao, Jianru, Meng, Tong, Zhou, Wang, Liu, Jianmin, Xu, Huji·2020·bioRxiv (Cold Spring Harbor Laboratory)

DOI 10.1101/2020.01.30.927806

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Abstract

Since December 2019, a newly identified coronavirus (2019 novel coronavirus, 2019-nCov) is causing outbreak of pneumonia in one of largest cities, Wuhan, in Hubei province of China and has draw significant public health attention. The same as severe acute respiratory syndrome coronavirus (SARS-CoV), 2019-nCov enters into host cells via cell receptor angiotensin converting enzyme II (ACE2). In order to dissect the ACE2-expressing cell composition and proportion and explore a potential route of the 2019-nCov infection in digestive system infection, 4 datasets with single-cell transcriptomes of lung, esophagus, gastric, ileum and colon were analyzed. The data showed that ACE2 was not only highly expressed in the lung AT2 cells, esophagus upper and stratified epithelial cells but also in absorptive enterocytes from ileum and colon. These results indicated along with respiratory systems, digestive system is a potential routes for 2019-nCov infection. In conclusion, this study has provided the bioinformatics evidence of the potential route for infection of 2019-nCov in digestive system along with respiratory tract and may have significant impact for our healthy policy setting regards to prevention of 2019-nCoV infection.

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Authors: Zhang, H., Kang, Z., Gong, H., Xu, D., Wang, J., Li, Z., Cui, X., Xiao, J., Meng, T., Zhou, W., Liu, J., & Xu, H.
Affiliations: Second Military Medical University (CN)
Tongji University (CN)
Center for Life Sciences (CN)
Corresponding author: Meng, Tong
Zhou, Wang
Liu, Jianmin
Xu, Huji
ORCID: Zhang, Hao
Kang, Zijian
Gong, Haiyi
Xu, Da
Wang, Jing
Li, Zifu
Cui, Xingang
Xiao, Jianru
Meng, Tong
Zhou, Wang
Liu, Jianmin
Xu, Huji
Venue: bioRxiv (Cold Spring Harbor Laboratory)
Publisher: openRxiv
Published: 2020-01-31
DOI: 10.1101/2020.01.30.927806
OpenAlex: W3004151654
Cited by: 658
References: 38
Citations by year: 2026: 2 · 2025: 2 · 2024: 39 · 2023: 31 · 2022: 46 · 2021: 154 · 2020: 384
Type: posted content
Language: en
Open access: green
doi.org
Licence: cc-by-nc-nd
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion, cc-by-nc-nd)
Topics: Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
Keywords: SARS-CoV-2, ACE2 receptor, gastrointestinal infections, enterocytes, intestinal epithelium, esophageal epithelium, single-cell transcriptomics, infection route, COVID-19 prevention

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The digestive system is a potential route of 2019-nCov infection: a bioinformatics analysis based on single-cell transcriptomes

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