The DOI matches its Crossref record; 137 of the 137 references it cites were found in a registry or an index.
HIV DNA Integration
Open accessAbstract
Retroviruses are distinguished from other viruses by two characteristic steps in the viral replication cycle. The first is reverse transcription, which results in the production of a double-stranded DNA copy of the viral RNA genome, and the second is integration, which results in covalent attachment of the DNA copy to host cell DNA. The initial catalytic steps of the integration reaction are performed by the virus-encoded integrase (IN) protein. The chemistry of the IN-mediated DNA breaking and joining steps is well worked out, and structures of IN-DNA complexes have now clarified how the overall complex assembles. Methods developed during these studies were adapted for identification of IN inhibitors, which received FDA approval for use in patients in 2007. At the chromosomal level, HIV integration is strongly favored in active transcription units, which may promote efficient viral gene expression after integration. HIV IN binds to the cellular factor LEDGF/p75, which promotes efficient infection and tethers IN to favored target sites. The HIV integration machinery must also interact with many additional host factors during infection, including nuclear trafficking and pore proteins during nuclear entry, histones during initial target capture, and DNA repair proteins during completion of the DNA joining steps. Models for some of the molecular mechanisms involved have been proposed, but important details remain to be clarified.
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“Integration of reverse transcribed viral DNA into the host cell genome is an essential step during the HIV-1 life cycle 1 .”
From Harnessing the CRISPR/Cas9 system to disrupt latent HIV-1 provirus (2013) · cites this paper as [1]
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“…have been performed to identify genes that when reduced in dosage using small interfering RNA (siRNA), diminish HIV infection, and several of the identified host factors have been mapped to the integration part of the viral replication cycle (Brass et al. 2008; Konig et al. 2008; Zhou et al. 2008).”
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Metadata
- Authors
- Craigie, R., & Bushman, F. D.
- Affiliations
- National Institutes of Health (US)
- University of Pennsylvania (US)
- Venue
- Cold Spring Harbor Perspectives in Medicine
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2012-05-08
- Volume
- 2
- Issue
- 7
- Pages
- a006890-a006890
- ISSN
- 2157-1422 (ISSN-L)
- PMC
- PMC3385939
- OpenAlex
- W2110488501
- Cited by
- 327
- References
- 137
- Citations by year
- 2026: 10 · 2025: 15 · 2024: 22 · 2023: 14 · 2022: 35 · 2021: 26 · 2020: 19 · 2019: 22 · 2018: 29 · 2017: 28 · 2016: 30 · 2015: 29 · 2014: 22 · 2013: 22 · 2012: 4
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Medicine (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (P01AI090935)
- Topics
- Life Sciences › Immunology and Microbiology › Virology › HIV Research and Treatment
- Health Sciences › Medicine › Infectious Diseases › HIV/AIDS drug development and treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Virus-based gene therapy research
- Keywords
- HIV integration, integrase, retroviral replication, reverse transcription, integrase inhibitors, LEDGF/p75, transcriptionally active chromatin, host factors, nuclear trafficking, histones, DNA repair, HIV gene expression
- MeSH terms
- Cell Nucleus, DNA, Viral, HIV, Humans, Virus Replication, Virus Integration, HIV Integrase, Intercellular Signaling Peptides and Proteins, Reverse Transcription
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