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Cited by 1,473

The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.

Insulin Receptor Signaling in Normal and Insulin-Resistant States

Open access
Boucher, J., Kleinridders, A., Kahn, C. R.·2014·Cold Spring Harbor Perspectives in Biology
DOI 10.1101/cshperspect.a009191
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Abstract

In the wake of the worldwide increase in type-2 diabetes, a major focus of research is understanding the signaling pathways impacting this disease. Insulin signaling regulates glucose, lipid, and energy homeostasis, predominantly via action on liver, skeletal muscle, and adipose tissue. Precise modulation of this pathway is vital for adaption as the individual moves from the fed to the fasted state. The positive and negative modulators acting on different steps of the signaling pathway, as well as the diversity of protein isoform interaction, ensure a proper and coordinated biological response to insulin in different tissues. Whereas genetic mutations are causes of rare and severe insulin resistance, obesity can lead to insulin resistance through a variety of mechanisms. Understanding these pathways is essential for development of new drugs to treat diabetes, metabolic syndrome, and their complications.

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Metadata

Authors
Boucher, J., Kleinridders, A., & Kahn, C. R.
Venue
Cold Spring Harbor Perspectives in Biology
Publisher
Cold Spring Harbor Laboratory
Published
2014-01-01
Volume
6
Issue
1
Pages
a009191-a009191
ISSN
1943-0264 (ISSN-L)
DOI
10.1101/cshperspect.a009191
OpenAlex
W2074076323
Cited by
1,473
References
51
Type
posted content
Language
en
Open access
bronze

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