TBC1D1 Regulates Insulin- and Contraction-Induced Glucose Transport in Mouse Skeletal Muscle

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Enhanced muscle insulin sensitivity after contraction/exercise is mediated by AMPK

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TBC1D4 Is Necessary for Enhancing Muscle Insulin Sensitivity in Response to AICAR and Contraction

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Mechanisms for increased insulin-stimulated Akt phosphorylation and glucose uptake in fast- and slow-twitch skeletal muscles of calorie-restricted rats

Sharma, N., Arias, E. B., Bhat, A. D., Sequea, D. A., Ho, S., Croff, K. K., Sajan, M. P., Farese, R. V., & Cartee, G. D. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00659.2010 · Cited by 60 · see citing works

Disruption of the AMPK–TBC1D1 nexus increases lipogenic gene expression and causes obesity in mice via promoting IGF1 secretion

Chen, L., Chen, Q., Xie, B., Quan, C., Sheng, Y., Zhu, S., Rong, P., Zhou, S., Sakamoto, K., MacKintosh, C., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1600581113 · Cited by 60 · see citing works

Clustering of GLUT4, TUG, and RUVBL2 protein levels correlate with myosin heavy chain isoform pattern in skeletal muscles, but AS160 and TBC1D1 levels do not

Castorena, C. M., MacKrell, J. G., Bogan, J. S., Kanzaki, M., & Cartee, G. D. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00631.2011 · Cited by 59 · see citing works

Liver and muscle circadian clocks cooperate to support glucose tolerance in mice

Smith, J. G., Koronowski, K. B., Mortimer, T., Sato, T., Greco, C. M., Petrus, P., Verlande, A., Chen, S., Samad, M., Deyneka, E., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112588 · Cited by 56 · see citing works

Myo1c Regulates Glucose Uptake in Mouse Skeletal Muscle

Toyoda, T., An, D., Witczak, C. A., Koh, H., Hirshman, M. F., FUJII, N. L., & Goodyear, L. J. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.174938 · Cited by 58 · see citing works

Homozygous staggerer (sg/sg) mice display improved insulin sensitivity and enhanced glucose uptake in skeletal muscle

Lau, P., Fitzsimmons, R. L., Pearen, M. A., Watt, M. J., & Muscat, G. E. O. (2011) · Diabetologia · doi:10.1007/s00125-011-2046-3 · Cited by 58 · see citing works

Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise

Hingst, J. R., Kjøbsted, R., Birk, J. B., Eskesen, N. O., Larsen, M. R., Kido, K., Larsen, J. K., Kjeldsen, S. A. S., Fentz, J., Frøsig, C., et al. (2020) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101028 · Cited by 54 · see citing works

Signaling, cytoskeletal and membrane mechanisms regulating GLUT4 exocytosis

Hoffman, N. J., & Elmendorf, J. S. (2011) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2010.12.001 · Cited by 55 · see citing works

Current advances in our understanding of exercise as medicine in metabolic disease

Sylow, L., & Richter, E. A. (2019) · Current Opinion in Physiology · doi:10.1016/j.cophys.2019.04.008 · Cited by 51 · see citing works

Liver and insulin resistance: New wine in old bottle!!!

Patel, B. M., & Goyal, R. K. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172657 · Cited by 50 · see citing works

Sensing and responding to energetic stress: Evolution of the AMPK network

Craig, P. M., Moyes, C. D., & LeMoine, C. M. R. (2018) · Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology · doi:10.1016/j.cbpb.2017.11.001 · Cited by 46 · see citing works

Post-translational Modifications: The Signals at the Intersection of Exercise, Glucose Uptake, and Insulin Sensitivity

Stocks, B., & Zierath, J. R. (2021) · Endocrine Reviews · doi:10.1210/endrev/bnab038 · Cited by 43 · see citing works

Ablating the protein TBC1D1 impairs contraction-induced sarcolemmal glucose transporter 4 redistribution but not insulin-mediated responses in rats

Whitfield, J., Paglialunga, S., Smith, B. K., Miotto, P. M., Simnett, G., Robson, H. L., Jain, S. S., Herbst, E. A. F., Desjardins, E. M., Dyck, D. J., et al. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m117.806786 · Cited by 42 · see citing works

Polyacetylenes from carrots ( Daucus carota ) improve glucose uptake in vitro in adipocytes and myotubes

El-Houri, R. B., Kotowska, D., Christensen, K. B., Bhattacharya, S., Oksbjerg, N., Wolber, G., Kristiansen, K., & Christensen, L. P. (2015) · Food & Function · doi:10.1039/c5fo00223k · Cited by 42 · see citing works

A Tbc1d1 Ser231Ala-knockin mutation partially impairs AICAR- but not exercise-induced muscle glucose uptake in mice

Chen, Q., Xie, B., Zhu, S., Rong, P., Sheng, Y., Ducommun, S., Chen, L., Quan, C., Li, M., Sakamoto, K., et al. (2016) · Diabetologia · doi:10.1007/s00125-016-4151-9 · Cited by 41 · see citing works

Insulin stimulation regulates AS160 and TBC1D1 phosphorylation sites in human skeletal muscle

Middelbeek, R. J. W., Chambers, M. A., Tantiwong, P., Treebak, J. T., An, D., Hirshman, M. F., Musi, N., & Goodyear, L. J. (2013) · Nutrition and Diabetes · doi:10.1038/nutd.2013.13 · Cited by 40 · see citing works

Regulation of RabGAPs involved in insulin action

Mafakheri, S., Chadt, A., & Al‐Hasani, H. (2018) · Biochemical Society Transactions · doi:10.1042/bst20170479 · Cited by 39 · see citing works

AKT and AMP-activated protein kinase regulate TBC1D1 through phosphorylation and its interaction with the cytosolic tail of insulin-regulated aminopeptidase IRAP

Mafakheri, S., FLÖRKE, R., Kanngießer, S., Hartwig, S., Espelage, L., de Wendt, C., Schönberger, T., Hamker, N., Lehr, S., Chadt, A., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.005040 · Cited by 40 · see citing works

GARNL1, a major RalGAP α subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins

Chen, Q., Quan, C., Xie, B., Chen, L., Zhou, S., Toth, R. L., Campbell, D. G., Lu, S., Shirakawa, R., Horiuchi, H., et al. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2014.04.012 · Cited by 39 · see citing works

Lipid oversupply induces CD36 sarcolemmal translocation via dual modulation of PKCζ and TBC1D1: an early event prior to insulin resistance

Zhu, B., Li, M., Lin, Q., Liang, Z., Xin, Q., Wang, M.-H., He, Z., Wang, X., Wu, X., Chen, G. G., et al. (2020) · Theranostics · doi:10.7150/thno.40021 · Cited by 39 · see citing works

Portulaca oleracea L. extract reduces hyperglycemia via PI3k/Akt and AMPK pathways in the skeletal muscles of C57BL/Ksj-db/db mice

Lee, J. H., Park, J. E., & Han, J.-S. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112973 · Cited by 39 · see citing works

Long-term treatment with nicotinamide induces glucose intolerance and skeletal muscle lipotoxicity in normal chow-fed mice: compared to diet-induced obesity

Qi, Z., Xia, J., Xue, X., He, Q., Ji, L., & Ding, S. (2016) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2016.07.005 · Cited by 37 · see citing works

Thr⁶⁴⁹Ala-AS160 knock-in mutation does not impair contraction/AICAR-induced glucose transport in mouse muscle

Ducommun, S., Wang, H. Y., Sakamoto, K., MacKintosh, C., & Chen, S. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00379.2011 · Cited by 35 · see citing works

Whole-exome sequencing identifies mutations of TBC1D1 encoding a Rab-GTPase-activating protein in patients with congenital anomalies of the kidneys and urinary tract (CAKUT)

Kosfeld, A., Kreuzer, M., Daniel, C., Brand, F. J., Schäfer, A.-K., Chadt, A., Weiss, A., Riehmer, V., Jeanpierre, C., Klintschar, M., et al. (2015) · Human Genetics · doi:10.1007/s00439-015-1610-1 · Cited by 36 · see citing works

Sustained AS160 and TBC1D1 phosphorylations in human skeletal muscle 30 min after a single bout of exercise

Vendelbo, M. H., Møller, A. B., Treebak, J. T., Gormsen, L. C., Goodyear, L. J., Wojtaszewski, J. F. P., Jørgensen, J. O. L., Møller, N., & Jessen, N. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00044.2014 · Cited by 34 · see citing works

RabGAPs in skeletal muscle function and exercise

Espelage, L., Al‐Hasani, H., & Chadt, A. (2019) · Journal of Molecular Endocrinology · doi:10.1530/jme-19-0143 · Cited by 33 · see citing works

Vitamin D repletion ameliorates adipose tissue browning and muscle wasting in infantile nephropathic cystinosis‐associated cachexia

Cheung, W. W., Sheng, H., Wang, Z., Ding, W. Q., Zheng, R., Gonzalez, A., Zhan, J., Zhou, P. H., Li, S., Esparza, M. C., et al. (2019) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12497 · Cited by 34 · see citing works

AKT/AMPK-mediated phosphorylation of TBC1D4 disrupts the interaction with insulin-regulated aminopeptidase

Eickelschulte, S., Hartwig, S., Leiser, B., Lehr, S., Joschko, V., Chokkalingam, M., Chadt, A., & Al‐Hasani, H. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100637 · Cited by 34 · see citing works

Identification and characterization of a novel Rab GTPase-activating protein in spermatids

Lin, Y., Lin, Y.-F., Kuo, Y., Wang, Y.-Y., & Kuo, P. (2010) · International Journal of Andrology · doi:10.1111/j.1365-2605.2010.01126.x · Cited by 29 · see citing works

Chemical genetic screen identifies Gapex-5/GAPVD1 and STBD1 as novel AMPK substrates

Ducommun, S., Deák, M., Zeigerer, A., Göransson, O., Seitz, S., Collodet, C., Madsen, A. B., Jensen, T. E., Viollet, B., Foretz, M., et al. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.02.001 · Cited by 28 · see citing works

Postexercise improvement in glucose uptake occurs concomitant with greater γ3-AMPK activation and AS160 phosphorylation in rat skeletal muscle

Wang, H., Arias, E. B., Pataky, M. W., Goodyear, L. J., & Cartee, G. D. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00020.2018 · Cited by 26 · see citing works

Revving the engine: PKB/AKT as a key regulator of cellular glucose metabolism

Li, X., Hu, S., Cai, Y., Liu, X., Luo, J., & Wu, T. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2023.1320964 · Cited by 25 · see citing works

TBC1D1 interacting proteins, VPS13A and VPS13C, regulate GLUT4 homeostasis in C2C12 myotubes

Hook, S. C., Chadt, A., Heesom, K. J., Kishida, S., Al‐Hasani, H., Tavaré, J. M., & Thomas, E. C. (2020) · Scientific Reports · doi:10.1038/s41598-020-74661-1 · Cited by 25 · see citing works

Role of AMP-Activated Protein Kinase for Regulating Post-exercise Insulin Sensitivity

Kjøbsted, R., Wojtaszewski, J. F. P., & Treebak, J. T. (2016) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-319-43589-3_5 · Cited by 26 · see citing works

Insulin Signaling and Glucose Uptake in the Soleus Muscle of 30-Month-Old Rats After Calorie Restriction With or Without Acute Exercise

Wang, H., Sharma, N., Arias, E. B., & Cartee, G. D. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glv142 · Cited by 24 · see citing works

Mechanisms for independent and combined effects of calorie restriction and acute exercise on insulin-stimulated glucose uptake by skeletal muscle of old rats

Sharma, N., Wang, H., Arias, E. B., Castorena, C. M., & Cartee, G. D. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00618.2014 · Cited by 23 · see citing works

Heterotypic endosomal fusion as an initial trigger for insulin‐induced glucose transporter 4 (GLUT4) translocation in skeletal muscle

Hatakeyama, H., & Kanzaki, M. (2017) · The Journal of Physiology · doi:10.1113/jp273985 · Cited by 23 · see citing works

α-Amyrin induces GLUT4 translocation mediated by AMPK and PPARδ/γ in C2C12 myoblasts

Giacoman‐Martínez, A., Alarcón-Aguilar, F. J., Zamilpa, A., Huang, F., Romero‐Nava, R., Román‐Ramos, R., & Almanza-Pérez, J. C. (2021) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2021-0027 · Cited by 22 · see citing works

Regulatory mode shift of Tbc1d1 is required for acquisition of insulin-responsive GLUT4-trafficking activity

Hatakeyama, H., & Kanzaki, M. (2013) · Molecular Biology of the Cell · doi:10.1091/mbc.e12-10-0725 · Cited by 22 · see citing works

Dammarane-type triterpene extracts of Panax notoginseng root ameliorates hyperglycemia and insulin sensitivity by enhancing glucose uptake in skeletal muscle

Kitamura, K., Takamura, Y., Iwamoto, T., Nomura, M., Iwasaki, H., Ohdera, M., Murakoshi, M., Sugiyama, K., Matsuyama, K., Manabe, Y., et al. (2016) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2016.1246173 · Cited by 22 · see citing works

Sex and fiber type independently influence AMPK, TBC1D1, and TBC1D4 at rest and during recovery from high-intensity exercise in humans

Tobias, I. S., Lazauskas, K. K., Siu, J. W., Costa, P. B., Coburn, J. W., & Galpin, A. J. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00704.2019 · Cited by 22 · see citing works

Deletion of the Rab GAP Tbc1d1 modifies glucose, lipid, and energy homeostasis in mice

Hargett, S. R., Walker, N. N., Hussain, S. S., Hoehn, K. L., & Keller, S. R. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00007.2015 · Cited by 21 · see citing works

Spatiotemporal Regulators for Insulin-Stimulated GLUT4 Vesicle Exocytosis

Zhou, X., Shentu, P., & Xu, Y. (2017) · Journal of Diabetes Research · doi:10.1155/2017/1683678 · Cited by 21 · see citing works

Calorie restriction leads to greater Akt2 activity and glucose uptake by insulin-stimulated skeletal muscle from old rats

Wang, H., Arias, E. B., & Cartee, G. D. (2016) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00449.2015 · Cited by 21 · see citing works

Exercise-Induced Improvement in Insulin-Stimulated Glucose Uptake by Rat Skeletal Muscle Is Absent in Male AS160-Knockout Rats, Partially Restored by Muscle Expression of Phosphomutated AS160, and Fully Restored by Muscle Expression of Wild-Type AS160

Zheng, A., Arias, E. B., Wang, H., Kwak, S. E., Pan, X., Duan, D., & Cartee, G. D. (2021) · Diabetes · doi:10.2337/db21-0601 · Cited by 20 · see citing works

TBC1D1 reduces palmitate oxidation by inhibiting β-HAD activity in skeletal muscle

Maher, A. C., McFarlan, J. T., Lally, J., Snook, L. A., & Bonen, A. (2014) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00014.2014 · Cited by 19 · see citing works

Exercise and Mitochondrial Remodeling in Skeletal Muscle in Type 2 Diabetes

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Insulin Signaling in Alzheimer’s Disease: Association with Brain Insulin Resistance

Pliszka, M., & Szablewski, L. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27031222 · Cited by 18 · see citing works

Increased postexercise insulin sensitivity is accompanied by increased AS160 phosphorylation in slow‐twitch soleus muscle

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The TBC1D1 Gene

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Genomewide association analysis for average birth interval and stillbirth in swine12

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Regulation of nutrient uptake by AMP-activated protein kinase

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Exploratory study on association of genetic variation in TBC1D1 with antipsychotic‐induced weight gain

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A Leptin Receptor Antagonist Attenuates Adipose Tissue Browning and Muscle Wasting in Infantile Nephropathic Cystinosis-Associated Cachexia

Gonzalez, A., Cheung, W. W., Perens, E. A., OLIVEIRA, E. A., Gertler, A., & MAK, R. H. K. (2021) · Cells · doi:10.3390/cells10081954 · Cited by 16 · see citing works

Roles of TBC1D1 and TBC1D4 in insulin- and exercise-stimulated glucose transport of skeletal muscle

Cartee, G. D. (2014) · Diabetologia · doi:10.1007/s00125-014-3395-5 · Cited by 153 · see citing works

The Rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism

Szekeres, F. L. M., Chadt, A., Tom, R. Z., Deshmukh, A. S., Chibalin, A., Björnholm, M., Al‐Hasani, H., & Zierath, J. R. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00605.2011 · Cited by 76 · see citing works

TBC1D1 regulates insulin- and contraction-induced glucose transport in mouse skeletal muscle. Diabetes 59:1358–1365

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The RabGAP TBC1D1 Plays a Central Role in Exercise-Regulated Glucose Metabolism in Skeletal Muscle

Stöckli, J., Meoli, C. C., Hoffman, N. J., Fazakerley, D. J., Pant, H., Cleasby, M. E., Ma, X., Kleinert, M., Brandon, A. E., Lopez, J. A., et al. (2015) · Diabetes · doi:10.2337/db13-1489 · Cited by 63 · see citing works

Let's get real about the regulation of TBC1D1 and TBC1D4 phosphorylation in skeletal muscle

Cartee, G. D. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2013.269092 · Cited by 1 · see citing works