The DOI matches its Crossref record; 245 of the 251 references it cites were found in a registry or an index.
An Overview of MYC and Its Interactome
Open accessAbstract
This review is intended to provide a broad outline of the biological and molecular functions of MYC as well as of the larger protein network within which MYC operates. We present a view of MYC as a sensor that integrates multiple cellular signals to mediate a broad transcriptional response controlling many aspects of cell behavior. We also describe the larger transcriptional network linked to MYC with emphasis on the MXD family of MYC antagonists. Last, we discuss evidence that the network has evolved for millions of years, dating back to the emergence of animals.
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“C-Myc forms a complex with Max through the bHLH-ZIP domain to activate gene transcription.415,416”
From Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials (2023) · cites this paper as [415]
In the citing paper
“Max is a constitutive expression protein with ubiquitous presence that plays a central role in controlling the Max-Max dimerin 1 (MXD1) axis.”
From Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials (2023) · cites this paper as [415]
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Cites
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“MBI mutations have been shown to increase oncogenicity in several tumor models (Hemann et al. 2005; Wang et al. 2011b; B Freie and RN Eisenman, unpubl.).”
BackgroundRNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
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Cited by
Sorted by citations
Stine, Z. E., Walton, Z. E., Altman, B. J., Hsieh, A. L., & Dang, C. V. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0507 · Cited by 1,435
The MYC oncogene — the grand orchestrator of cancer growth and immune evasion
Dhanasekaran, R., Deutzmann, A., Mahauad‐Fernandez, W. D., Hansen, A. S., Gouw, A. M., & Felsher, D. W. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00549-2 · Cited by 1,044
MYC Activation Is a Hallmark of Cancer Initiation and MaintenancePreprint
Gabay, M., Li, Y., & Felsher, D. W. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014241 · Cited by 841
MYC, Metabolism, Cell Growth, and TumorigenesisPreprint
Dang, C. V. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014217 · Cited by 625
MYC as a target for cancer treatment
Duffy, M. J., O’Grady, S., Tang, M., & Crown, J. P. (2021) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2021.102154 · Cited by 533
Metadata
- Authors
- Conacci-Sorrell, M., McFerrin, L., & Eisenman, R. N.
- Affiliations
- Fred Hutch Cancer Center (US)
- ORCID
- Eisenman, R. N.
- Venue
- Cold Spring Harbor Perspectives in Medicine
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2014-01-01
- Volume
- 4
- Issue
- 1
- Pages
- a014357-a014357
- ISSN
- 2157-1422 (ISSN-L)
- PMC
- PMC3869278
- OpenAlex
- W2159290008
- Cited by
- 408
- References
- 251
- Citations by year
- 2026: 20 · 2025: 24 · 2024: 45 · 2023: 39 · 2022: 23 · 2021: 34 · 2020: 57 · 2019: 41 · 2018: 34 · 2017: 22 · 2016: 22 · 2015: 21 · 2014: 22
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Cold Spring Harbor Perspectives in Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Cancer Institute (R37CA57138, R01CA020525, R37CA057138, R01-CA20525)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- c-Myc, transcriptional regulation, signal integration, cell behavior, animal evolution
- MeSH terms
- Animals, Biological Evolution, Humans, Repressor Proteins, Transcription, Genetic, Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, Genes, myc, Proto-Oncogene Proteins c-myc, Gene Regulatory Networks, Carcinogenesis
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