Cited by 412Cancer-related Molecular PathwaysGenomics and Chromatin DynamicsDevelopmental Biology and Gene Regulation

The DOI matches its Crossref record; 245 of the 251 references it cites were found in a registry or an index.

An Overview of MYC and Its Interactome

Open access

Conacci-Sorrell, M., McFerrin, L., Eisenman, R. N.·2014·Cold Spring Harbor Perspectives in Medicine

DOI 10.1101/cshperspect.a014357PMC PMC3869278

Open this paper in CoChat — free account Open PDF

Abstract

This review is intended to provide a broad outline of the biological and molecular functions of MYC as well as of the larger protein network within which MYC operates. We present a view of MYC as a sensor that integrates multiple cellular signals to mediate a broad transcriptional response controlling many aspects of cell behavior. We also describe the larger transcriptional network linked to MYC with emphasis on the MXD family of MYC antagonists. Last, we discuss evidence that the network has evolved for millions of years, dating back to the emergence of animals.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1101/cshperspect.a014357

Cites

245 of 245 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The landscape of somatic copy-number alteration across human cancers
Beroukhim, R., Mermel, C. H., Porter, D., Wei, G., Raychaudhuri, S., Donovan, J., Barretina, J., Boehm, J. S., Dobson, J., Urashima, M., et al. (2010) · Nature · doi:10.1038/nature08822 · Cited by 4,017
Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers
Lovén, J., Hoke, H. A., Lin, C. Y., Lau, A., Orlando, D. A., Vakoc, C. R., Bradner, J. E., Lee, T. I., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.03.036 · Cited by 2,961
BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc
Delmore, J. E., Issa, G. C., Lemieux, M. E., Rahl, P. B., Shi, J., Jacobs, H. M., Kastritis, E., Gilpatrick, T., Paranal, R. M., Qi, J., et al. (2011) · Cell · doi:10.1016/j.cell.2011.08.017 · Cited by 2,888
A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins
Murre, C., Page-McCaw, P., & Baltimore, D. (1989) · Cell · doi:10.1016/0092-8674(89)90682-x · Cited by 2,713
Amplification of N- myc in Untreated Human Neuroblastomas Correlates with Advanced Disease Stage
Brodeur, G. M., Seeger, R. C., Schwab, M., VARMUS, H. E., & Bishop, J. M. (1984) · Science · doi:10.1126/science.6719137 · Cited by 2,261
Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor
Kelly, K., Cochran, B., Stiles, C. D., & Leder, P. (1983) · Cell · doi:10.1016/0092-8674(83)90092-2 · Cited by 2,227
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140 · cited 2×
“MBI mutations have been shown to increase oncogenicity in several tumor models (Hemann et al. 2005; Wang et al. 2011b; B Freie and RN Eisenman, unpubl.).”
Background
RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia
Zuber, J., Shi, J., Wang, E., Rappaport, A. R., Herrmann, H., Sison, E. A., Magoon, D., Qi, J., Blatt, K., Wunderlich, M., et al. (2011) · Nature · doi:10.1038/nature10334 · Cited by 1,870
The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
Adams, J. M., Harris, A. W., Pinkert, C. A., Corcoran, L. M., Alexander, W. S., Cory, S., Palmiter, R. D., & Brinster, R. L. (1985) · Nature · doi:10.1038/318533a0 · Cited by 1,779
Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.
Dalla‐Favera, R., Bregni, M., Erikson, J., Patterson, D., Gallo, R. C., & Croce, C. M. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.24.7824 · Cited by 1,764

Show all 251 references

Sorted by citations

MYC, Metabolism, and Cancer
Stine, Z. E., Walton, Z. E., Altman, B. J., Hsieh, A. L., & Dang, C. V. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0507 · Cited by 1,435
The MYC oncogene — the grand orchestrator of cancer growth and immune evasion
Dhanasekaran, R., Deutzmann, A., Mahauad‐Fernandez, W. D., Hansen, A. S., Gouw, A. M., & Felsher, D. W. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00549-2 · Cited by 1,044
MYC Activation Is a Hallmark of Cancer Initiation and MaintenancePreprint
Gabay, M., Li, Y., & Felsher, D. W. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014241 · Cited by 841
MYC, Metabolism, Cell Growth, and TumorigenesisPreprint
Dang, C. V. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014217 · Cited by 625
MYC as a target for cancer treatment
Duffy, M. J., O’Grady, S., Tang, M., & Crown, J. P. (2021) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2021.102154 · Cited by 533
Germinal centres and B cell lymphomagenesis
Basso, K., & Dalla-Favera, R. (2015) · Nature Reviews Immunology · doi:10.1038/nri3814 · Cited by 510
Therapeutic targeting of “undruggable” MYC
Llombart, V., & Mansour, M. R. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103756 · Cited by 507
Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells
Yan, W., Wu, X., Zhou, W., Fong, M., Cao, M., Liu, J., Liu, X., Chen, C.-H., Fadare, O., Pizzo, D. P., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0083-6 · Cited by 474
Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas
Schaub, F. X., Dhankani, V., Berger, A. C., Trivedi, M., Richardson, A. B., Shaw, R., Zhao, W., Zhang, X., Ventura, A., Liu, Y., et al. (2018) · Cell Systems · doi:10.1016/j.cels.2018.03.003 · Cited by 431
“In contrast to the predominant transcriptional activation function of MYC, the MXD, MXI1, MNT, and MGA proteins repress transcription through the recruitment of corepressor complexes (for reviews see Conacci-Sorrell et al., 2014; Link and Hurlin, 2015).”
Self-citation
Recent advances in targeting the “undruggable” proteins: from drug discovery to clinical trials
Xie, X., Yu, T., Li, X., Zhang, N., Foster, L. J., Peng, C., Huang, W., & He, G. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01589-z · Cited by 396
Pharmacological properties and derivatives of shikonin—A review in recent years
Guo, C., He, J., Song, X., Tan, L., Wang, M., Jiang, P., Li, Y., Cao, Z., & Peng, C. Y. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104463 · Cited by 388
Target gene-independent functions of MYC oncoproteins
Baluapuri, A., Wolf, E., & Eilers, M. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0215-2 · Cited by 310
The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis
Carroll, P. A., Freie, B. W., Mathsyaraja, H., & Eisenman, R. N. (2018) · Frontiers of Medicine · doi:10.1007/s11684-018-0650-z · Cited by 289
Self-citation
Strategies to Inhibit Myc and Their Clinical Applicability
Whitfield, J. R., Beaulieu, M.-È., & Soucek, L. (2017) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2017.00010 · Cited by 303
Directly visualized glioblastoma-derived extracellular vesicles transfer RNA to microglia/macrophages in the brain
van der Vos, K. E., Abels, E. R., Zhang, X., Lai, C., Carrizosa, E., Oakley, D., Prabhakar, S., Mardini, O., Crommentuijn, M. H. W., Skog, J., et al. (2016) · Neuro-Oncology · doi:10.1093/neuonc/nov244 · Cited by 315
Genetics of diffuse large B-cell lymphoma
Pasqualucci, L., & Dalla‐Favera, R. (2018) · Blood · doi:10.1182/blood-2017-11-764332 · Cited by 308
MYC Oncogene Contributions to Release of Cell Cycle Brakes
García-Gutiérrez, L., Delgado, M. D., & León, J. (2019) · Genes · doi:10.3390/genes10030244 · Cited by 264
Metabolic reprogramming in triple-negative breast cancer
Sun, X., Wang, M., Wang, M., Yu, X., Guo, J., Sun, T., Li, X., Yao, L., Dong, H., & Xu, Y. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00428 · Cited by 243
Therapeutic Strategies to Inhibit MYCPreprint
McKeown, M. R., & Bradner, J. E. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014266 · Cited by 231
The OncoPPi network of cancer-focused protein–protein interactions to inform biological insights and therapeutic strategies
Li, Z., Ivanov, A. A., Su, R., González-Pecchi, V., Qi, Q., Liu, S., Webber, P. J., McMillan, E. A., Rusnak, L., Pham, C., et al. (2017) · Nature Communications · doi:10.1038/ncomms14356 · Cited by 232
Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy
Beaulieu, M.-È., Jauset, T., Massó-Vallés, D., Martínez-Martín, S., Rahl, P. B., Maltais, L., Fluck, M. F. Z., Casacuberta‐Serra, S., del Pozo, E. S., Fiore, C., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aar5012 · Cited by 212
Deregulated Myc Requires MondoA/Mlx for Metabolic Reprogramming and Tumorigenesis
Carroll, P. A., Diolaiti, D., McFerrin, L. G., Gu, H., Djukovic, D., Du, J., Cheng, P. F., Anderson, S., Ulrich, M. L., Hurley, J. B., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2014.11.024 · Cited by 202
Self-citation
HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma
Tavana, O., Li, D., Dai, C., López, G., Banerjee, D., Kon, N., Chen, C., Califano, A., Yamashiro, D. J., Sun, H., et al. (2016) · Nature Medicine · doi:10.1038/nm.4180 · Cited by 202
CDK9-mediated transcription elongation is required for MYC addiction in hepatocellular carcinomaPreprint
Huang, C., Lujambio, A., Zuber, J. A., Tschaharganeh, D. F., Doran, M. G., Evans, M. J., Kitzing, T. M., Zhu, N., de Stanchina, E., Sawyers, C. L., et al. (2014) · Genes & Development · doi:10.1101/gad.244368.114 · Cited by 204
The Role for Myc in Coordinating Glycolysis, Oxidative Phosphorylation, Glutaminolysis, and Fatty Acid Metabolism in Normal and Neoplastic Tissues
Goetzman, E. S., & Prochownik, E. V. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00129 · Cited by 199
Role of MYC in medulloblastoma
Roussel, M. F., & Robinson, G. W. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014308 · Cited by 180
The MYCN Protein in Health and Disease
Ruiz-Pérez, M. V., Henley, A. B., & Arsenian‐Henriksson, M. (2017) · Genes · doi:10.3390/genes8040113 · Cited by 191
Therapeutic Inhibition of Myc in Cancer. Structural Bases and Computer-Aided Drug Discovery Approaches
Carabet, L. A., Rennie, P. S., & Cherkasov, A. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms20010120 · Cited by 172
“Myc is under extremely tight control by the cell, but defects in its regulation lead to its overabundance and aberrant expression that are characteristic of many cancers [13].”
BackgroundInfluential
MYC: a complex problem
Das, S., Lewis, B. A., & Levens, D. (2022) · Trends in Cell Biology · doi:10.1016/j.tcb.2022.07.006 · Cited by 166
Occupancy maps of 208 chromatin-associated proteins in one human cell type
Partridge, E. C., Chhetri, S. B., Prokop, J. W., Ramaker, R. C., Jansen, C. S., Goh, S.-T., Mackiewicz, M., Newberry, K. M., Brandsmeier, L. A., Meadows, S. K., et al. (2020) · Nature · doi:10.1038/s41586-020-2023-4 · Cited by 154
A Myc-dependent division timer complements a cell-death timer to regulate T cell and B cell responses
Heinzel, S., Giang, T. B., Kan, A., Marchingo, J. M., Lye, B., Corcoran, L. M., & Hodgkin, P. D. (2016) · Nature Immunology · doi:10.1038/ni.3598 · Cited by 167
Different promoter affinities account for specificity in MYC-dependent gene regulation
Lorenzin, F., Benary, U., Baluapuri, A., Walz, S., Jung, L. A., von Eyß, B., Kisker, C., Wolf, J., Eilers, M., & Wolf, E. (2016) · eLife · doi:10.7554/elife.15161 · Cited by 165
MYC protein stability is negatively regulated by BRD4
Devaiah, B. N., Mu, J., Akman, B., Uppal, S., Weissman, J. D., Cheng, D., Baranello, L., Nie, Z., Levens, D., & Singer, D. S. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1919507117 · Cited by 159
MYC in pancreatic cancer: novel mechanistic insights and their translation into therapeutic strategies
Heßmann, E., Schneider, G., Ellenrieder, V., & Siveke, J. T. (2015) · Oncogene · doi:10.1038/onc.2015.216 · Cited by 178
Mission Possible: Advances in MYC Therapeutic Targeting in Cancer
Allen-Petersen, B. L., & Sears, R. C. (2019) · BioDrugs · doi:10.1007/s40259-019-00370-5 · Cited by 150
MYC Is a Major Determinant of Mitotic Cell Fate
Topham, C. H., Tighe, A., Ly, P., Bennett, A., Sloss, O., Nelson, L., Ridgway, R. A., Huels, D. J., Littler, S., Schandl, C., et al. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.06.001 · Cited by 144
Blocking Myc to Treat Cancer: Reflecting on Two Decades of Omomyc
Massó-Vallés, D., & Soucek, L. (2020) · Cells · doi:10.3390/cells9040883 · Cited by 146
Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription
Struntz, N. B., Chen, A., Deutzmann, A., Wilson, R. M., Stefan, E., Evans, H. L., Ramirez, M. A., Liang, T., Caballero, F., Wildschut, M. H. E., et al. (2019) · Cell Chemical Biology · doi:10.1016/j.chembiol.2019.02.009 · Cited by 130
FoxO transcription factors in cancer metabolism
Yadav, R. K., Chauhan, A. S., Zhuang, L., & Gan, B. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.01.004 · Cited by 138
Inhibition of CDK4/6 Promotes CD8 T-cell Memory Formation
Heckler, M., Ali, L. R., Clancy-Thompson, E., Li, Q., Ventre, K. S., Lenehan, P., Roehle, K., Luoma, A., Boelaars, K., Peters, V., et al. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1540 · Cited by 133
c-MYC-Induced Genomic InstabilityPreprint
Kuzyk, R., & Mai, S. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014373 · Cited by 127
Transcription Factor Inhibition: Lessons Learned and Emerging Targets
Chen, A. W., & Koehler, A. N. (2020) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2020.01.004 · Cited by 123
The Role of MIZ-1 in MYC-Dependent TumorigenesisPreprint
Wiese, K. E., Walz, S., von Eyß, B., Wolf, E., Athineos, D., Sansom, O. J., & Eilers, M. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014290 · Cited by 114
Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer
Wiegering, A., Uthe, F. W., Jamieson, T. J., Ruoss, Y., Hüttenrauch, M., Küspert, M., Pfann, C., Nixon, C., Herold, S., Walz, S., et al. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-14-1040 · Cited by 119
Structural and Biophysical Insights into the Function of the Intrinsically Disordered Myc Oncoprotein
Beaulieu, M.-È., Castillo, F., & Soucek, L. (2020) · Cells · doi:10.3390/cells9041038 · Cited by 110
MYC Targeted Long Noncoding RNA DANCR Promotes Cancer in Part by Reducing p21 Levels
Lu, Y., Hu, Z., Mangala, L. S., Stine, Z. E., Hu, Z., Jiang, D., Xiang, Y., Zhang, Y., Pradeep, S., Rodriguez‐Aguayo, C., et al. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0815 · Cited by 111
MYC and Transcription ElongationPreprint
Rahl, P. B., & Young, R. A. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a020990 · Cited by 119
Genome Recognition by MYCPreprint
Sabò, A., & Amati, B. B. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014191 · Cited by 107
PRMT5-dependent transcriptional repression of c-Myc target genes promotes gastric cancer progression
Liu, M., Yao, B., Gui, T., Guo, C., Wu, X., Li, J., Ma, L., Deng, Y., Xu, P., Wang, Y., et al. (2020) · Theranostics · doi:10.7150/thno.42047 · Cited by 108
MYC in Regulating Immunity: Metabolism and Beyond
Gnanaprakasam, J. R., & Wang, R. (2017) · Genes · doi:10.3390/genes8030088 · Cited by 111
MYC in cancer: from undruggable target to clinical trials
Whitfield, J. R., & Soucek, L. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01143-2 · Cited by 106
Stress-Induced Epstein-Barr Virus Reactivation
Sausen, D. G., Bhutta, M., Gallo, E. S., Dahari, H., & Borenstein, R. (2021) · Biomolecules · doi:10.3390/biom11091380 · Cited by 108
C-myc Contributes to Malignancy of Lung Cancer: A Potential Anticancer Drug Target
Pithi Chanvorachote, B., Sriratanasak, N., & Nonpanya, N. (2020) · Anticancer Research · doi:10.21873/anticanres.13990 · Cited by 104
MYC function and regulation in physiological perspective
Jha, R., Kouzine, F., & Levens, D. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1268275 · Cited by 107
Cancer cell metabolism and the modulating effects of nitric oxide
Chang, C.-F., Diers, A. R., & Hogg, N. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.11.012 · Cited by 103
The long journey to bring a Myc inhibitor to the clinic
Whitfield, J. R., & Soucek, L. (2021) · The Journal of Cell Biology · doi:10.1083/jcb.202103090 · Cited by 101
Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia
Huang, L., Liu, D., Wang, N., Ling, S., Tang, Y., Wu, J., Hao, L., Luo, H., Hu, X., Sheng, L., et al. (2017) · Cell Research · doi:10.1038/cr.2017.146 · Cited by 96
Inhibition of MUC1-C Suppresses MYC Expression and Attenuates Malignant Growth in KRAS Mutant Lung Adenocarcinomas
Bouillez, A., Rajabi, H. N., Pitroda, S. P., Jin, C., Alam, M., Kharbanda, A., Tagde, A., Wong, K., & Kufe, D. W. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-1804 · Cited by 95
Molecular Crosstalk Between MYC and HIF in Cancer
Li, Y., Sun, X., Qian, D. Z., & Dai, M. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.590576 · Cited by 95
Drugging “undruggable” genes for cancer treatment: Are we making progress?
Duffy, M. J., & Crown, J. P. (2020) · International Journal of Cancer · doi:10.1002/ijc.33197 · Cited by 86
The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity
Vo, B. T., Wolf, E., Kawauchi, D., Gebhardt, A., Rehg, J. E., Finkelstein, D., Walz, S., Murphy, B. L., Youn, Y. H., Han, Y.-G., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2015.12.003 · Cited by 86
Imp/IGF2BP levels modulate individual neural stem cell growth and division through myc mRNA stability
Samuels, T. J., Järvelin, A. I., Ish‐Horowicz, D., & Davis, I. (2020) · eLife · doi:10.7554/elife.51529 · Cited by 75
MYC regulates the non-coding transcriptome
Hart, J. R., Roberts, T. C., Weinberg, M. S., Morris, K. V., & Vogt, P. K. (2014) · Oncotarget · doi:10.18632/oncotarget.3033 · Cited by 85
MYC and the unfolded protein response in cancer: synthetic lethal partners in crime?
Zhang, T., Li, N., Sun, C., Jin, Y., & Sheng, X. (2020) · EMBO Molecular Medicine · doi:10.15252/emmm.201911845 · Cited by 79
Blood feeding activates the vitellogenic stage of oogenesis in the mosquito Aedes aegypti through inhibition of glycogen synthase kinase 3 by the insulin and TOR pathways
Valzania, L., Mattee, M. T., Strand, M. R., & Brown, M. R. (2019) · Developmental Biology · doi:10.1016/j.ydbio.2019.05.011 · Cited by 86
Growth suppression by MYC inhibition in small cell lung cancer cells with TP53 and RB1 inactivation
Fiorentino, F. P., Tokgün, P. E., Solé‐Sánchez, S., Giampaolo, S., Tokgün, O., Jauset, T., Kohno, T., Perucho, M., Soucek, L., & Yokota, J. (2016) · Oncotarget · doi:10.18632/oncotarget.8826 · Cited by 80
Myc stimulates cell cycle progression through the activation of Cdk1 and phosphorylation of p27
García-Gutiérrez, L., Bretones, G., Molina, E., Aréchaga, I., Symonds, C. E., Acosta, J. C., Blanco, R. E., Fernández, A., Alonso, L., Siciński, P., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-54917-1 · Cited by 77
BRD4 and MYC : power couple in transcription and disease
Kotekar, A., Singh, A. K., & Devaiah, B. N. (2022) · FEBS Journal · doi:10.1111/febs.16580 · Cited by 77
MYC and KRAS cooperation: from historical challenges to therapeutic opportunities in cancer
Casacuberta‐Serra, S., González-Larreategui, Í., Capitán-Leo, D., & Soucek, L. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01907-z · Cited by 84
Polymer effects modulate binding affinities in disordered proteins
Vancraenenbroeck, R., Harel, Y. S., Zheng, W., & Hofmann, H. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1904997116 · Cited by 75
Prototypical oncogene family Myc defines unappreciated distinct lineage states of small cell lung cancer
Patel, A. S., Yoo, S., Kong, R., Sato, T., Sinha, A., Karam, S., Bao, L., Fridrikh, M., Emoto, K., Nudelman, G., et al. (2021) · Science Advances · doi:10.1126/sciadv.abc2578 · Cited by 73
c-Myc promotes renal fibrosis by inducing integrin αv-mediated transforming growth factor-β signaling
Shen, Y., Miao, N., Wang, B., Xu, J., Gan, X., Xu, D., Zhou, L., Xue, H., Zhang, W., Yang, L., et al. (2017) · Kidney International · doi:10.1016/j.kint.2017.03.006 · Cited by 73
Polyploid Giant Cancer Cells, a Hallmark of Oncoviruses and a New Therapeutic Challenge
Herbein, G., & Nehme, Z. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.567116 · Cited by 70
The MYC–WDR5 Nexus and Cancer
Thomas, L. R., Foshage, A. M., Weissmiller, A. M., & Tansey, W. P. (2015) · Cancer Research · doi:10.1158/0008-5472.can-15-1216 · Cited by 69
Taking on Challenging Targets: Making MYC Druggable
Horiuchi, D., Anderton, B. N., & Goga, A. (2014) · American Society of Clinical Oncology Educational Book · doi:10.14694/edbook_am.2014.34.e497 · Cited by 67
Dissecting transcriptional amplification by MYC
Nie, Z., Guo, C., Das, S., Chow, C. C., Batchelor, E., Simons, S. S., & Levens, D. (2020) · eLife · doi:10.7554/elife.52483 · Cited by 68
Synthetic Lethal Screens as a Means to Understand and Treat MYC-Driven CancersPreprint
Cermelli, S., Jang, I. S., Bernard, B. M., & Grandori, C. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014209 · Cited by 71
Control of cell metabolism by the epidermal growth factor receptor
Orofiamma, L. A., Vural, D., & Antonescu, C. N. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2022.119359 · Cited by 73
Menin enhances c-Myc-mediated transcription to promote cancer progression
Wu, G., Yuan, M., Shen, S., Ma, X., Fang, J., Zhu, L., Sun, L., Liu, Z., He, X., Huang, D., et al. (2017) · Nature Communications · doi:10.1038/ncomms15278 · Cited by 69
Recent advances in searching c-Myc transcriptional cofactors during tumorigenesis
Caforio, M., Sorino, C., Iacovelli, S., Fanciulli, M., Locatelli, F., & Folgiero, V. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0912-2 · Cited by 64
Multi-transcriptome analysis following an acute skeletal muscle growth stimulus yields tools for discerning global and MYC regulatory networks
Murach, K. A., Liu, Z., Jude, B., Figueiredo, V. C., Wen, Y., Khadgi, S., Lim, S., da Silva, F. M., Greene, N. P., Lanner, J. T., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102515 · Cited by 60
MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability
Dingar, D. D., Tu, W. B., Resetca, D., Lourenco, C., Tamachi, A., Melo, J. D., Houlahan, K. E., Kalkat, M., Chan, P.-K., Boutros, P. C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-05660-0 · Cited by 62
MYC Cofactors: Molecular Switches Controlling Diverse Biological OutcomesPreprint
Hann, S. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014399 · Cited by 60
A MYC inhibitor selectively alters the MYC and MAX cistromes and modulates the epigenomic landscape to regulate target gene expression
Holmes, A. G., Parker, J. B., Sagar, V., Truica, M. I., Soni, P. N., Han, H., Schiltz, G. E., Abdulkadir, S. A., & Chakravarti, D. (2022) · Science Advances · doi:10.1126/sciadv.abh3635 · Cited by 61
Targeting WD Repeat-Containing Protein 5 (WDR5): A Medicinal Chemistry Perspective
Chen, X., Xu, J., Wang, X., Long, G., You, Q., & Guo, X. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00037 · Cited by 63
MYC and EGR1 synergize to trigger tumor cell death by controlling NOXA and BIM transcription upon treatment with the proteasome inhibitor bortezomib
Wirth, M., Stojanovic, N., Christian, J. G., Paul, M. C., Stauber, R. H., Schmid, R. M., Häcker, G. A., Krämer, O. H., Saur, D., & Schneider, G. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku763 · Cited by 62
Resetting cancer stem cell regulatory nodes upon MYC inhibition
Galardi, S., Savino, M., Scagnoli, F., Pellegatta, S., Pisati, F., Zambelli, F., Illi, B., Annibali, D., Beji, S., Orecchini, E., et al. (2016) · EMBO Reports · doi:10.15252/embr.201541489 · Cited by 58
Crystal Structures and Nuclear Magnetic Resonance Studies of the Apo Form of the c-MYC:MAX bHLHZip Complex Reveal a Helical Basic Region in the Absence of DNA
Sammak, S., Hamdani, N., Gorrec, F., Allen, M. D., Freund, S. M. V., Bycroft, M., & Zinzalla, G. (2019) · Biochemistry · doi:10.1021/acs.biochem.9b00296 · Cited by 59
Two diphosphorylated degrons control c-Myc degradation by the Fbw7 tumor suppressor
Welcker, M., Wang, B., Rusnac, D.-V., Hussaini, Y., Swanger, J., Zheng, N., & Clurman, B. E. (2022) · Science Advances · doi:10.1126/sciadv.abl7872 · Cited by 57
Diffuse large B cell lymphoma (DLBCL): epidemiology, pathophysiology, risk stratification, advancement in diagnostic approaches and prospects: narrative review
Berhan, A., Almaw, A., Damtie, S., & Solomon, Y. (2025) · Discover Oncology · doi:10.1007/s12672-025-01958-w · Cited by 62
Proteins Recognizing DNA: Structural Uniqueness and Versatility of DNA-Binding Domains in Stem Cell Transcription Factors
Yesudhas, D., Batool, M., Anwar, M. A., Panneerselvam, S., & Choi, S. (2017) · Genes · doi:10.3390/genes8080192 · Cited by 57
microRNA-193a stimulates pancreatic cancer cell repopulation and metastasis through modulating TGF-β2/TGF-βRIII signalings
Fang, C., Dai, C.-Y., Mei, Z., Jiang, M., Gu, D.-N., Huang, Q., & Tian, L. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0697-3 · Cited by 57
MYC-activated RNA N6-methyladenosine reader IGF2BP3 promotes cell proliferation and metastasis in nasopharyngeal carcinoma
Du, M., Peng, Y., Yang, L., Sun, W., Zhu, H., Wu, J., Zong, D., Wu, L., & He, X. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-00844-6 · Cited by 56
MYC regulates a pan-cancer network of co-expressed oncogenic splicing factors
Urbanski, L. M., Brugiolo, M., Park, S., Angarola, B. L., Leclair, N. K., Yurieva, M., Palmer, P., Sahu, S. K., & Anczuków, O. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111704 · Cited by 53
Neuroblastoma: A Tough Nut to Crack
Speleman, F., Park, J. R., & Henderson, T. O. (2016) · American Society of Clinical Oncology Educational Book · doi:10.1200/edbk_159169 · Cited by 62
MYC and the Art of MicroRNA MaintenancePreprint
Psathas, J. N., & Thomas‐Tikhonenko, A. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014175 · Cited by 55
Max deletion destabilizes MYC protein and abrogates Eµ- Myc lymphomagenesis
Mathsyaraja, H., Freie, B., Cheng, P.-F., Babaeva, E., Catchpole, J. T., Janssens, D., Henikoff, S., & Eisenman, R. N. (2019) · Genes & Development · doi:10.1101/gad.325878.119 · Cited by 54
Self-citation
Computer-aided drug discovery of Myc-Max inhibitors as potential therapeutics for prostate cancer
Carabet, L. A., Lallous, N., Leblanc, E., Ban, F., Morin, H., Lawn, S. O., Ghaidi, F., Lee, J., Mills, I. G., Gleave, M. E., et al. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.09.023 · Cited by 56
miR-342-3p regulates MYC transcriptional activity via direct repression of E2F1 in human lung cancer
Tai, M.-C., Kajino, T., Nakatochi, M., Arima, C., Shimada, Y., Suzuki, M., Miyoshi, H., Yatabe, Y., Yanagisawa, K., & Takahashi, T. (2015) · Carcinogenesis · doi:10.1093/carcin/bgv152 · Cited by 53
Essential Role for Polycomb Group Protein Pcgf6 in Embryonic Stem Cell Maintenance and a Noncanonical Polycomb Repressive Complex 1 (PRC1) Integrity
Zhao, W., Tong, H., Huang, Y., Yan, Y., Teng, H., Xia, Y. Y., Jiang, Q. Y., & Qin, J. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.763961 · Cited by 52

Authors: Conacci-Sorrell, M., McFerrin, L., & Eisenman, R. N.
Affiliations: Fred Hutch Cancer Center (US)
ORCID: Eisenman, R. N.
Venue: Cold Spring Harbor Perspectives in Medicine
Publisher: Cold Spring Harbor Laboratory
Published: 2014-01-01
Volume: 4
Issue: 1
Pages: a014357-a014357
ISSN: 2157-1422 (ISSN-L)
DOI: 10.1101/cshperspect.a014357
PMC: PMC3869278
OpenAlex: W2159290008
Cited by: 408
References: 251
Citations by year: 2026: 20 · 2025: 24 · 2024: 45 · 2023: 39 · 2022: 23 · 2021: 34 · 2020: 57 · 2019: 41 · 2018: 34 · 2017: 22 · 2016: 22 · 2015: 21 · 2014: 22
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Cold Spring Harbor Perspectives in Medicine (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Cancer Institute (R37CA57138, R01CA020525, R37CA057138, R01-CA20525)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Keywords: c-Myc, transcriptional regulation, signal integration, cell behavior, animal evolution
MeSH terms: Animals, Biological Evolution, Humans, Repressor Proteins, Transcription, Genetic, Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, Genes, myc, Proto-Oncogene Proteins c-myc, Gene Regulatory Networks, Carcinogenesis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

An Overview of MYC and Its Interactome

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks