An Overview of MYC and Its Interactome

The landscape of somatic copy-number alteration across human cancers

Beroukhim, R., Mermel, C. H., Porter, D., Wei, G., Raychaudhuri, S., Donovan, J., Barretina, J., Boehm, J. S., Dobson, J., Urashima, M., et al. (2010) · Nature · doi:10.1038/nature08822 · Cited by 4,017

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

Lovén, J., Hoke, H. A., Lin, C. Y., Lau, A., Orlando, D. A., Vakoc, C. R., Bradner, J. E., Lee, T. I., & Young, R. A. (2013) · Cell · doi:10.1016/j.cell.2013.03.036 · Cited by 2,961

BET Bromodomain Inhibition as a Therapeutic Strategy to Target c-Myc

Delmore, J. E., Issa, G. C., Lemieux, M. E., Rahl, P. B., Shi, J., Jacobs, H. M., Kastritis, E., Gilpatrick, T., Paranal, R. M., Qi, J., et al. (2011) · Cell · doi:10.1016/j.cell.2011.08.017 · Cited by 2,888

A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins

Murre, C., Page-McCaw, P., & Baltimore, D. (1989) · Cell · doi:10.1016/0092-8674(89)90682-x · Cited by 2,713

Amplification of N- myc in Untreated Human Neuroblastomas Correlates with Advanced Disease Stage

Brodeur, G. M., Seeger, R. C., Schwab, M., VARMUS, H. E., & Bishop, J. M. (1984) · Science · doi:10.1126/science.6719137 · Cited by 2,261

Cell-specific regulation of the c-myc gene by lymphocyte mitogens and platelet-derived growth factor

Kelly, K., Cochran, B., Stiles, C. D., & Leder, P. (1983) · Cell · doi:10.1016/0092-8674(83)90092-2 · Cited by 2,227

The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140 · cited 2×

RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Zuber, J., Shi, J., Wang, E., Rappaport, A. R., Herrmann, H., Sison, E. A., Magoon, D., Qi, J., Blatt, K., Wunderlich, M., et al. (2011) · Nature · doi:10.1038/nature10334 · Cited by 1,870

The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

Adams, J. M., Harris, A. W., Pinkert, C. A., Corcoran, L. M., Alexander, W. S., Cory, S., Palmiter, R. D., & Brinster, R. L. (1985) · Nature · doi:10.1038/318533a0 · Cited by 1,779

Human c-myc onc gene is located on the region of chromosome 8 that is translocated in Burkitt lymphoma cells.

Dalla‐Favera, R., Bregni, M., Erikson, J., Patterson, D., Gallo, R. C., & Croce, C. M. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.24.7824 · Cited by 1,764

Max: A Helix-Loop-Helix Zipper Protein That Forms a Sequence-Specific DNA-Binding Complex with Myc

Blackwood, E. M., & Eisenman, R. N. (1991) · Science · doi:10.1126/science.2006410 · Cited by 1,681

Activation of a cellular onc gene by promoter insertion in ALV-induced lymphoid leukosis

Hayward, W. S., Neel, B. G., & Astrin, S. M. (1981) · Nature · doi:10.1038/290475a0 · Cited by 1,569

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

Lin, C. Y., Lovén, J., Rahl, P. B., Paranal, R. M., Burge, C. B., Bradner, J. E., Lee, T. I., & Young, R. A. (2012) · Cell · doi:10.1016/j.cell.2012.08.026 · Cited by 1,543

Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

Dawson, M. A., Prinjha, R. K., Dittmann, A., Giotopoulos, G., Bantscheff, M., Chan, W.-I., Robson, S. C., Chung, C., Hopf, C., Savitski, M. M., et al. (2011) · Nature · doi:10.1038/nature10509 · Cited by 1,530

Two Rounds of Whole Genome Duplication in the Ancestral Vertebrate

Dehal, P., & Boore, J. L. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030314 · Cited by 1,526

Translocation of the c-myc gene into the immunoglobulin heavy chain locus in human Burkitt lymphoma and murine plasmacytoma cells.

Taub, R. A., Kirsch, I. R., Morton, C. C., Lenoir, G., Swan, D., Tronick, S. R., Aaronson, S. A., & Leder, P. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.24.7837 · Cited by 1,421

Multiple Ras-dependent phosphorylation pathways regulate Myc protein stabilityPreprint

Sears, R. C., Nuckolls, F., Haura, E. B., Taya, Y., Tamai, K., & Nevins, J. R. (2000) · Genes & Development · doi:10.1101/gad.836800 · Cited by 1,411

Amplified DNA with limited homology to myc cellular oncogene is shared by human neuroblastoma cell lines and a neuroblastoma tumour

Schwab, M., Alitalo, K. K., Klempnauer, K.-H., VARMUS, H. E., Bishop, J. M., Gilbert, F., Brodeur, G. M., Goldstein, M. N., & Trent, J. M. (1983) · Nature · doi:10.1038/305245a0 · Cited by 1,405

c-Myc Regulates Transcriptional Pause Release

Rahl, P. B., Lin, C. Y., Seila, A. C., Flynn, R. A., McCuine, S., Burge, C. B., Sharp, P. A., & Young, R. A. (2010) · Cell · doi:10.1016/j.cell.2010.03.030 · Cited by 1,279

A complex containing N-CoR, mSln3 and histone deacetylase mediates transcriptional repression

Heinzel, T., Lavinsky, R. M., Mullen, T.-M., Söderström, M., Laherty, C. D., Torchia, J., Yang, W., Brard, G., Ngo, S. D., Davie, J., et al. (1997) · Nature · doi:10.1038/387043a0 · Cited by 1,210

MYC oncogenes and human neoplastic disease

Nesbit, C. E., Tersak, J. M., & Prochownik, E. V. (1999) · Oncogene · doi:10.1038/sj.onc.1202746 · Cited by 1,163

Targeting MYC dependence in cancer by inhibiting BET bromodomains

Mertz, J. A., Conery, A. R., Bryant, B. M., Sandy, P., Balasubramanian, S., Mele, D. A., Bergeron, L., & Sims, R. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1108190108 · Cited by 1,145

c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells

Nie, Z., Hu, G., Wei, G., Cui, K., Yamane, A., Resch, W., Wang, R., Green, D. R., Tessarollo, L., Casellas, R. C., et al. (2012) · Cell · doi:10.1016/j.cell.2012.08.033 · Cited by 1,106

FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation

Welcker, M., & Clurman, B. E. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2290 · Cited by 1,084

Genomic targets of the human c-Myc proteinPreprint

Fernandez, P. C., Frank, S. R., Wang, L., Schroeder, M., Liu, S., Greene, J. R., Cocito, A., & Amati, B. B. (2003) · Genes & Development · doi:10.1101/gad.1067003 · Cited by 963

The Fbw7 tumor suppressor regulates glycogen synthase kinase 3 phosphorylation-dependent c-Myc protein degradation

Welcker, M., Orian, A., Jin, J., Grim, J. A., Harper, J. W., Eisenman, R. N., & Clurman, B. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402770101 · Cited by 942

Histone Deacetylases Associated with the mSin3 Corepressor Mediate Mad Transcriptional Repression

Laherty, C. D., Yang, W., Sun, J.-M., Davie, J., Seto, E., & Eisenman, R. N. (1997) · Cell · doi:10.1016/s0092-8674(00)80215-9 · Cited by 933

Myc’s broad reach

Eilers, M., & Eisenman, R. N. (2008) · Genes & Development · doi:10.1101/gad.1712408 · Cited by 927

c-Myc Can Induce DNA Damage, Increase Reactive Oxygen Species, and Mitigate p53 Function

Vafa, O., Wade, M., Kern, S., Beeche, M., Pandita, T. K., Hampton, G. M., & Wahl, G. M. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00520-8 · Cited by 876

Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression

Alland, L., Muhle, R., Hou, H., Potes, J., Chin, L., Schreiber‐Agus, N., & DePinho, R. A. (1997) · Nature · doi:10.1038/387049a0 · Cited by 841

MYC Activation Is a Hallmark of Cancer Initiation and MaintenancePreprint

Gabay, M., Li, Y., & Felsher, D. W. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014241 · Cited by 841

RNA tumor viruses

Weiss, R. A., & Bernstein, A. (1982) · Cold Spring Harbor Laboratory eBooks · Cited by 828

MyoD is a sequence-specific DNA binding protein requiring a region of myc homology to bind to the muscle creatine kinase enhancer

Lassar, A. B., Buskin, J. N., Lockshon, D., Davis, R. L., Apone, S., Hauschka, S. D., & Weintraub, H. M. (1989) · Cell · doi:10.1016/0092-8674(89)90935-5 · Cited by 817

Phosphorylation‐dependent degradation of c‐Myc is mediated by the F‐box protein Fbw7

Yada, M., Hatakeyama, S., Kamura, T., Nishiyama, M., Tsunematsu, R., Imaki, H., Ishida, N., Okumura, F., Nakayama, K., & Nakayama, K. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600217 · Cited by 810

LIF/STAT3 controls ES cell self-renewal and pluripotency by a Myc-dependent mechanism

Cartwright, P., McLean, C. A., Sheppard, A. M., Rivett, D., Jones, K., & Dalton, S. (2005) · Development · doi:10.1242/dev.01670 · Cited by 790

A Complex with Chromatin Modifiers That Occupies E2F- and Myc-Responsive Genes in G 0 Cells

Ogawa, H., Ishiguro, K., Gaubatz, S., Livingston, D. M., & Nakatani, Y. (2002) · Science · doi:10.1126/science.1069861 · Cited by 785

Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites

Zervos, A. S., Gyuris, J., & Brent, R. (1993) · Cell · doi:10.1016/0092-8674(93)90662-a · Cited by 769

Homogeneously staining chromosomal regions contain amplified copies of an abundantly expressed cellular oncogene (c-myc) in malignant neuroendocrine cells from a human colon carcinoma.

Alitalo, K., Schwab, M., Lin, C. C., Varmus, H. E., & Bishop, J. M. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.6.1707 · Cited by 761

Histone Deacetylase Activity Is Required for Full Transcriptional Repression by mSin3A

Hassig, C. A., Fleischer, T. C., Billin, A. N., Schreiber, S. L., & Ayer, D. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80214-7 · Cited by 740

Transposition and amplification of oncogene-related sequences in human neuroblastomas

Kohl, N. E., Kanda, N., Schreck, R. R., Bruns, G. A. P., Latt, S. A., Gilbert, F., & Alt, F. W. (1983) · Cell · doi:10.1016/0092-8674(83)90169-1 · Cited by 729

Recognition by Max of its cognate DNA through a dimeric b/HLH/Z domain

Ferré-D’Amaré, A. R., Prendergast, G. C., Ziff, E. B., & Burley, S. K. (1993) · Nature · doi:10.1038/363038a0 · Cited by 719

Mad: A heterodimeric partner for Max that antagonizes Myc transcriptional activity

Ayer, D. E., Kretzner, L., & Eisenman, R. N. (1993) · Cell · doi:10.1016/0092-8674(93)90661-9 · Cited by 697

The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins

McMahon, S. B., Van Buskirk, H. A., Dugan, K. A., Copeland, T. D., & Cole, M. D. (1998) · Cell · doi:10.1016/s0092-8674(00)81479-8 · Cited by 693

A Myc Network Accounts for Similarities between Embryonic Stem and Cancer Cell Transcription Programs

Kim, J., Woo, A. J., Chu, J., Snow, J. W., Fujiwara, Y., Kim, C. G., Cantor, A. B., & Orkin, S. H. (2010) · Cell · doi:10.1016/j.cell.2010.09.010 · Cited by 683

Non-transcriptional control of DNA replication by c-Myc

Dominguez-Sola, D., Ying, C. Y., Grandori, C., Ruggiero, L., Chen, B., Li, M., Galloway, D. A., Gu, W. J., Gautier, J., & Dalla‐Favera, R. (2007) · Nature · doi:10.1038/nature05953 · Cited by 671

Neuroblastoma and MYCNPreprint

Huang, M., & Weiss, W. A. (2013) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014415 · Cited by 660

L-myc, a new myc-related gene amplified and expressed in human small cell lung cancer

Nau, M. M., Brooks, B. J., Battey, J. F., Sausville, E. A., Gazdar, A. F., Kirsch, I. R., McBride, O. W., Bertness, V. L., Hollis, G. F., & Minna, J. D. (1985) · Nature · doi:10.1038/318069a0 · Cited by 649

Drosophila myc Regulates Cellular Growth during Development

Johnston, L. A., Prober, D. A., Edgar, B. A., Eisenman, R. N., & Gallant, P. (1999) · Cell · doi:10.1016/s0092-8674(00)81512-3 · Cited by 648

Targeting MYCN in Neuroblastoma by BET Bromodomain Inhibition

Puissant, A., Frumm, S. M., Alexe, G., Bassil, C. F., Qi, J., Chanthery, Y. H., Nekritz, E. A., Zeid, R., Gustafson, W. C., Greninger, P., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0418 · Cited by 648

Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas

Payne, G. S., Bishop, J. M., & VARMUS, H. E. (1982) · Nature · doi:10.1038/295209a0 · Cited by 625

Revisiting Global Gene Expression Analysis

Lovén, J., Orlando, D. A., Sigova, A. A., Lin, C. Y., Rahl, P. B., Burge, C. B., Levens, D. L., Lee, T. I., & Young, R. A. (2012) · Cell · doi:10.1016/j.cell.2012.10.012 · Cited by 616

onc gene amplification in promyelocytic leukaemia cell line HL-60 and primary leukaemic cells of the same patient

Favera, R. D., Wong‐Staal, F., & Gallo, R. C. (1982) · Nature · doi:10.1038/299061a0 · Cited by 615

Amplification of endogenous myc-related DNA sequences in a human myeloid leukaemia cell line

Collins, S. J., & Groudine, M. T. (1982) · Nature · doi:10.1038/298679a0 · Cited by 613

Mad-max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3

Ayer, D. E., Lawrence, Q., & Eisenman, R. N. (1995) · Cell · doi:10.1016/0092-8674(95)90355-0 · Cited by 587

Histone Deacetylases and SAP18, a Novel Polypeptide, Are Components of a Human Sin3 Complex

Zhang, Y., Iratni, R., Erdjument-Bromage, H., Tempst, P., & Reinberg, D. (1997) · Cell · doi:10.1016/s0092-8674(00)80216-0 · Cited by 578

The Myc oncoprotein as a therapeutic target for human cancer

Vita, M. F., & Arsenian‐Henriksson, M. (2006) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2006.07.015 · Cited by 575

Oncogenic activity of the c-Myc protein requires dimerization with Max

Amati, B. B., Brooks, M. W., Levy-Strumpf, N., Littlewood, T. D., Evan, G. I., & Land, H. (1993) · Cell · doi:10.1016/0092-8674(93)90663-b · Cited by 566

X-Ray Structures of Myc-Max and Mad-Max Recognizing DNA

Nair, S. K., & Burley, S. K. (2003) · Cell · doi:10.1016/s0092-8674(02)01284-9 · Cited by 551

Exome sequencing identifies MAX mutations as a cause of hereditary pheochromocytoma

Comino‐Méndez, I., Gracia-Aznárez, F. J., Schiavi, F., Landa, I., Leandro-Garcia, L. J., Letón, R., Honrado, E., Ramos‐Medina, R., Caronia, D., Pita, G., et al. (2011) · Nature Genetics · doi:10.1038/ng.861 · Cited by 528

Global mapping of c-Myc binding sites and target gene networks in human B cells

Zeller, K. I., Zhao, X., Lee, C. W. H., Chiu, K. P., Yao, F., Yustein, J. T., Ooi, H., Orlov, Y. L., Shahab, A., Yong, H. C., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604129103 · Cited by 521

Skp2 Regulates Myc Protein Stability and Activity

Kim, S. Y., Herbst, A., Tworkowski, K. A., Salghetti, S. E., & Tansey, W. P. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00173-4 · Cited by 516

Proteins Encoded by the Human c-myc Oncogene: Differential Expression in Neoplastic Cells

Hann, S., & Eisenman, R. N. (1984) · Molecular and Cellular Biology · doi:10.1128/mcb.4.11.2486 · Cited by 498

The F-Box Protein Skp2 Participates in c-Myc Proteosomal Degradation and Acts as a Cofactor for c-Myc-Regulated Transcription

von der Lehr, N., Johansson, S. M., Wu, S., Bahram, F., Castell, A., Cetinkaya, C., Hydbring, P., Weidung, I., Nakayama, K., Nakayama, K., et al. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00193-x · Cited by 486

c-Myc Proteolysis by the Ubiquitin-Proteasome Pathway: Stabilization of c-Myc in Burkitt's Lymphoma Cells

Gregory, M. A., & Hann, S. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.7.2423-2435.2000 · Cited by 469

MYC degradation

Farrell, A. S., & Sears, R. C. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014365 · Cited by 468

Novel myc oncogene RNA from abortive immunoglobulin-gene recombination in mouse plasmacytomas

Shen-Ong, G. L. C., Keath, E. J., Piccoli, S. P., & Cole, M. D. (1982) · Cell · doi:10.1016/0092-8674(82)90137-4 · Cited by 454

Evasion of the p53 tumour surveillance network by tumour-derived MYC mutants

Hemann, M. T., Bric, A., Teruya‐Feldstein, J., Herbst, A., Nilsson, J. A., Cordon‐Cardo, C., Cleveland, J. L., Tansey, W. P., & Lowe, S. W. (2005) · Nature · doi:10.1038/nature03845 · Cited by 452

Definition of Regions in Human c-myc that are Involved in Transformation and Nuclear Localization

Stone, J. C., de Lange, T., Ramsay, G. M., Jakobovits, E. B., Bishop, J. M., VARMUS, H. E., & Lee, W. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.5.1697 · Cited by 450

Destruction of Myc by ubiquitin‐mediated proteolysis: cancer‐associated and transforming mutations stabilize Myc

Salghetti, S. E., Kim, S. Y., & Tansey, W. P. (1999) · The EMBO Journal · doi:10.1093/emboj/18.3.717 · Cited by 445

Myc and Max proteins possess distinct transcriptional activities

Kretzner, L., Blackwood, E. M., & Eisenman, R. N. (1992) · Nature · doi:10.1038/359426a0 · Cited by 445

Direct activation of RNA polymerase III transcription by c-Myc

Gomez-Roman, N., Grandori, C., Eisenman, R. N., & White, R. J. (2003) · Nature · doi:10.1038/nature01327 · Cited by 434

The histone H3K4 demethylase SMCX links REST target genes to X-linked mental retardation

Tahiliani, M., Mei, P., Fang, R., Leonor, T., Rutenberg, M. S., Shimizu, F., Li, J., Rao, A., & Shi, Y. G. (2007) · Nature · doi:10.1038/nature05823 · Cited by 429

Three new types of viral oncogene of cellular origin specific for haematopoietic cell transformation

Roussel, M. F., Saule, S., Lagrou, C., Rommens, C., Beug, H., Graf, T., & Stéhelin, D. (1979) · Nature · doi:10.1038/281452a0 · Cited by 423

Avian leukemia viruses interaction with their target cells in vivo and in vitro

Graf, T., & Beug, H. (1978) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(78)90011-2 · Cited by 418

Myc and Max associate in vivo.Preprint

Blackwood, E. M., Lüscher, B., & Eisenman, R. N. (1992) · Genes & Development · doi:10.1101/gad.6.1.71 · Cited by 415

c-MYC interacts with INI1/hSNF5 and requires the SWI/SNF complex for transactivation function

Cheng, S., Davies, K. P., Yung, E., Beltran, R. J., Yu, J. C., & Kalpana, G. V. (1999) · Nature Genetics · doi:10.1038/8811 · Cited by 396

Structure and function of the b/HLH/Z domain of USF.

Ferré-D’Amaré, A. R., Pognonec, P., Roeder, R. G., & Burley, S. K. (1994) · The EMBO Journal · doi:10.1002/j.1460-2075.1994.tb06247.x · Cited by 394

Genomic binding by the Drosophila Myc, Max, Mad/Mnt transcription factor networkPreprint

Orian, A., van Steensel, B., Delrow, J. J., Bussemaker, H. J., Li, L., Sawado, T., Williams, E., Loo, L. W. M., Cowley, S. M., Yost, C., et al. (2003) · Genes & Development · doi:10.1101/gad.1066903 · Cited by 385

Myc-binding-site recognition in the human genome is determined by chromatin context

Guccione, E., Martinato, F., Finocchiaro, G., Luzi, L., Tizzoni, L., Olio, V. D., Zardo, G., Nervi, C., Bernard, L., & Amati, B. B. (2006) · Nature Cell Biology · doi:10.1038/ncb1434 · Cited by 373

c-myc oncogene protein synthesis is independent of the cell cycle in human and avian cells

Hann, S., Thompson, C. B., & Eisenman, R. N. (1985) · Nature · doi:10.1038/314366a0 · Cited by 369

An amino-terminal domain of Mxi1 mediates anti-myc oncogenic activity and interacts with a homolog of the Yeast Transcriptional Repressor SIN3

Schreiber‐Agus, N., Chin, L., Chen, K., Torres, R., Rao, G., Guida, P. M., Skoultchi, A. I., & DePinho, R. A. (1995) · Cell · doi:10.1016/0092-8674(95)90356-9 · Cited by 364

An alternative pathway for gene regulation by Myc

Peukert, K., Staller, P., Schneider, A., Carmichael, G., Hänel, F., & Eilers, M. (1997) · The EMBO Journal · doi:10.1093/emboj/16.18.5672 · Cited by 359

Phospho Switch Triggers Brd4 Chromatin Binding and Activator Recruitment for Gene-Specific Targeting

Wu, S.-Y., Lee, A.-Y., Lai, H., Zhang, H., & Chiang, C. (2013) · Molecular Cell · doi:10.1016/j.molcel.2012.12.006 · Cited by 350

The Ubiquitin Ligase FBXW7 Modulates Leukemia-Initiating Cell Activity by Regulating MYC Stability

King, B., Trimarchi, T., Reavie, L. B., Xu, L., Mullenders, J., Ntziachristos, P., Aranda-Orgillés, B., Pérez-García, A., Shi, J., Vakoc, C. R., et al. (2013) · Cell · doi:10.1016/j.cell.2013.05.041 · Cited by 349

Regulation of cyclin D2 gene expression by the Myc/Max/Mad network: Myc-dependent TRRAP recruitment and histone acetylation at the cyclin D2 promoterPreprint

Bouchard, C., Dittrich, O., Kiermaier, A. C., Dohmann, K., Menkel, A. R., Eilers, M., & Lüscher, B. (2001) · Genes & Development · doi:10.1101/gad.907901 · Cited by 345

High mutation rate and predominance of insertions in the Caenorhabditis elegans nuclear genome

Denver, D. R., Morris, K., Lynch, M., & Thomas, W. K. (2004) · Nature · doi:10.1038/nature02697 · Cited by 340

Mad3 and Mad4: novel Max‐interacting transcriptional repressors that suppress c‐myc dependent transformation and are expressed during neural and epidermal differentiation.

Hurlin, P. J., Quéva, C., Koskinen, P. J., Steingrı́msson, E., Ayer, D. E., Copeland, N. G., Jenkins, N. A., & Eisenman, R. N. (1995) · The EMBO Journal · doi:10.1002/j.1460-2075.1995.tb00252.x · Cited by 337

Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells

Xu, D., Popov, N., Hou, M., Wang, Q., Björkholm, M., Gruber, A., Menkel, A. R., & Arsenian‐Henriksson, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.071043198 · Cited by 324

A Nucleolar Isoform of the Fbw7 Ubiquitin Ligase Regulates c-Myc and Cell Size

Welcker, M., Orian, A., Grim, J. A., Eisenman, R. N., & Clurman, B. E. (2004) · Current Biology · doi:10.1016/j.cub.2004.09.083 · Cited by 311

A switch from Myc:Max to Mad:Max heterocomplexes accompanies monocyte/macrophage differentiation.Preprint

Ayer, D. E., & Eisenman, R. N. (1993) · Genes & Development · doi:10.1101/gad.7.11.2110 · Cited by 293

Proteins encoded by v-myc and c-myc oncogenes: Identification and localization in acute leukemia virus transformants and bursal lymphoma cell lines

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MicroRNA miR-210 modulates cellular response to hypoxia through the MYC antagonist MNT

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Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc

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Isolation and characterization of s-myc, a member of the rat myc gene family.

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Genetic Structure of Avian Acute Leukemia VirusesPreprint

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Repression of Myc-Ras cotransformation by Mad is mediated by multiple protein-protein interactions.

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MYC Cofactors: Molecular Switches Controlling Diverse Biological OutcomesPreprint

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Loss of the Max-interacting protein Mnt in mice results in decreased viability, defective embryonic growth and craniofacial defects: relevance to Miller-Dieker syndrome

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Cellular MYCro Economics: Balancing MYC Function with MYC ExpressionPreprint

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New members of the Drosophila Myc transcription factor subfamily revealed by a genome-wide examination for basic helix-loop-helix genes

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Max and inhibitory c-Myc mutants induce erythroid differentiation and resistance to apoptosis in human myeloid leukemia cells

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Myc/Max/Mad in Invertebrates: The Evolution of the Max Network

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Identification and Characterization of SAP25, a Novel Component of the mSin3 Corepressor Complex

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The Transcriptional Repressor dMnt Is a Regulator of Growth in Drosophila melanogaster

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MYC, Metabolism, and Cancer

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The MYC oncogene — the grand orchestrator of cancer growth and immune evasion

Dhanasekaran, R., Deutzmann, A., Mahauad‐Fernandez, W. D., Hansen, A. S., Gouw, A. M., & Felsher, D. W. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00549-2 · Cited by 1,044

MYC Activation Is a Hallmark of Cancer Initiation and MaintenancePreprint

Gabay, M., Li, Y., & Felsher, D. W. (2014) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a014241 · Cited by 841

MYC, Metabolism, Cell Growth, and TumorigenesisPreprint

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MYC as a target for cancer treatment

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Abstract IA01: Myc functions within a transcriptional regulatory network

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The MYC transcription factor network: balancing metabolism, proliferation and oncogenesis

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The Myc/Max/Mad Network and the Transcriptional Control of Cell Behavior

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Functional interactions among members of the MAX and MLX transcriptional network during oncogenesis

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The MYC network: Hub of malignancy and blueprint for intervention

Yin, H., Liu, T., & Pan, J. (2026) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2026.189651 · Cited by 1