The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
Astrocyte Development and Heterogeneity
Open accessAbstract
Astrocytes have many roles within the brain parenchyma, and a subpopulation restricted to germinal niches functions as neural stem cells (NSCs) that produce various types of neuronal progeny in relation to spatiotemporal factors. A growing body of evidence supports the concept of morphological and molecular differences between astrocytes in different brain regions, which might relate to their derivation from regionally patterned radial glia. Indeed, the notion that astrocytes are molecularly and functionally heterogeneous could help explain how the central nervous system (CNS) retains embryonic positional information into adulthood. Here, we discuss recent evidence for regionally encoded functions of astrocytes in the developing and adult CNS to provide an integrated concept of the origin and possible function of astrocyte heterogeneity. We focus on the regionalization of NSCs in the ventricular-subventricular zone (V-SVZ) of the adult mammalian brain and emerging evidence for a segmental organization of astrocytes in the developing spinal cord and forebrain. We propose that astrocytes' diversity will provide fundamental clues to understand regional brain organization and function.
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Cites
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BackgroundNeuropilin Is a Semaphorin III Receptor
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Cited by
Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678
Diversity of astrocyte functions and phenotypes in neural circuits
Khakh, B. S., & Sofroniew, M. V. (2015) · Nature Neuroscience · doi:10.1038/nn.4043 · Cited by 1,239
Cell Biology of Astrocyte-Synapse Interactions
Allen, N. J., & Eroglu, C. (2017) · Neuron · doi:10.1016/j.neuron.2017.09.056 · Cited by 1,098
von Bartheld, C. S., Bahney, J., & Herculano‐Houzel, S. (2016) · Journal of Comparative Neurology · doi:10.1002/cne.24040 · Cited by 1,063
Glia as architects of central nervous system formation and function
Allen, N. J., & Lyons, D. A. (2018) · Science · doi:10.1126/science.aat0473 · Cited by 1,001
Metadata
- Authors
- Bayraktar, O. A., Fuentealba, L. C., Alvarez-Buylla, A., & Rowitch, D. H.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2014-11-20
- Volume
- 7
- Issue
- 1
- Pages
- a020362
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W2101369162
- Cited by
- 342
- References
- 103
- Type
- posted content
- Language
- en
- Open access
- green
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- Bayraktar, O. A., Fuentealba, L. C., Alvarez-Buylla, A., & Rowitch, D. H. (2015). Astrocyte Development and Heterogeneity. Cold Spring Harbor Perspectives in Biology. https://doi.org/10.1101/cshperspect.a020362
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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