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Cell Biology of Astrocyte-Synapse Interactions
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Aberrant function of astrocytes can have detrimental effects on neuronal plasticity.
“These findings are in agreement with previous studies showing that aberrant function of astrocytes can have detrimental effects on neuronal plasticity [85].”
From A role for astrocytic miR-129-5p in frontotemporal dementia (2025) · cites this paper as [85]
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“…Down syndrome astrocytes show decreased expression of multiple synaptogenic proteins, including TSP1 and Gpc6, and like with fragile X syndrome, the addition of TSP1 to Down syndrome astrocytes is sufficient to rescue some of the synaptogenic deficits (Chen et al., 2014; Garcia et al., 2010).”
Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
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Self-citationAstrocyte glypicans 4 and 6 promote formation of excitatory synapses via GluA1 AMPA receptors
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Self-citationTrophic Interactions Between Astroglial Cells and Hippocampal Neurons in Culture
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Phenotypic Heterogeneity and Plasticity of Isocortical and Hippocampal Astrocytes in the Human Brain
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Improved tools to study astrocytes
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“In the healthy adult brain, astrocytes are rather stationary cells, forming a well-coordinated network in the parenchyma [5].”
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“…MECP2 loss in neurons are considered the primary drivers of synaptic dysfunctions, recent studies have also demonstrated a role for non-cell-autonomous mechanisms largely mediated by astrocytes, which strongly influence neuronal maturation and function (Allen & Eroglu, 2017; Postogna et al., 2025).”
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Metadata
- Authors
- Allen, N. J., & Eroglu, C.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2017-11
- Volume
- 96
- Issue
- 3
- Pages
- 697-708
- ISSN
- 0896-6273
- PMC
- PMC5687890
- Cited by
- 1,098
- References
- 22
- Language
- en
- Licence
- Funders
- NIH/NINDS (R01 NS089791, R01 NS096352)
- Hearst
- Pew
- Ellison
- Dana
- NIH/NIDA (R01 DA031833)
- NIH/NIEHS (R01 ES025549)
- Simons Foundation (#400729)
- Holland-Trice Brain Research Foundation
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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