The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Central Nervous System Regenerative Failure: Role of Oligodendrocytes, Astrocytes, and Microglia
Open accessAbstract
Animal studies are now showing the exciting potential to achieve significant functional recovery following central nervous system (CNS) injury by manipulating both the inefficient intracellular growth machinery in neurons, as well as the extracellular barriers, which further limit their regenerative potential. In this review, we have focused on the three major glial cell types: oligodendrocytes, astrocytes, and microglia/macrophages, in addition to some of their precursors, which form major extrinsic barriers to regrowth in the injured CNS. Although axotomized neurons in the CNS have, at best, a limited capacity to regenerate or sprout, there is accumulating evidence that even in the adult and, especially after boosting their growth motor, neurons possess the capacity for considerable circuit reorganization and even lengthy regeneration when these glial obstacles to neuronal regrowth are modified, eliminated, or overcome.
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Cites
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Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury
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The Potential Role of Gut Microbiota in Alzheimer’s Disease: From Diagnosis to Treatment
Varesi, A., Pierella, E., Romeo, M., Piccini, G. B., Alfano, C., Bjørklund, G., Oppong, A., Ricevuti, G., Esposito, C., Chirumbolo, S., et al. (2022) · Nutrients · doi:10.3390/nu14030668 · Cited by 225
Metadata
- Authors
- Silver, J., Schwab, M. E., & Popovich, P. G.
- Venue
- Cold Spring Harbor Perspectives in Biology
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2014-12-04
- Volume
- 7
- Issue
- 3
- Pages
- a020602
- ISSN
- 1943-0264 (ISSN-L)
- OpenAlex
- W6910810655
- Cited by
- 332
- References
- 25
- Type
- posted content
- Language
- en
- Open access
- bronze
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- Silver, J., Schwab, M. E., & Popovich, P. G. (2015). Central Nervous System Regenerative Failure: Role of Oligodendrocytes, Astrocytes, and Microglia. Cold Spring Harbor Perspectives in Biology. https://doi.org/10.1101/cshperspect.a020602
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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