The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury
Open accessAbstract
CNS injury often severs axons. Scar tissue that forms locally at the lesion site is thought to block axonal regeneration, resulting in permanent functional deficits. We report that inhibiting the generation of progeny by a subclass of pericytes led to decreased fibrosis and extracellular matrix deposition after spinal cord injury in mice. Regeneration of raphespinal and corticospinal tract axons was enhanced and sensorimotor function recovery improved following spinal cord injury in animals with attenuated pericyte-derived scarring. Using optogenetic stimulation, we demonstrate that regenerated corticospinal tract axons integrated into the local spinal cord circuitry below the lesion site. The number of regenerated axons correlated with improved sensorimotor function recovery. In conclusion, attenuation of pericyte-derived fibrosis represents a promising therapeutic approach to facilitate recovery following CNS injury.
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CNS fibroblasts form a fibrotic scar in response to immune cell infiltration.
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Molecular anatomy of adult mouse leptomeninges
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Metadata
- Authors
- Dias, D. O., Kim, H., Holl, D., Werne Solnestam, B., Lundeberg, J., Carlén, M., Göritz, C., & Frisén, J.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2018-03
- Volume
- 173
- Issue
- 1
- Pages
- 153-165.e22
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2793900597
- Cited by
- 391
- References
- 66
- FWCI
- 22.02
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Dias, D. O., Kim, H., Holl, D., Werne Solnestam, B., Lundeberg, J., Carlén, M., Göritz, C., & Frisén, J. (2018). Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury. Cell. https://doi.org/10.1016/j.cell.2018.02.004
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