The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Resistance to Macrolide Antibiotics in Public Health Pathogens
Open accessAbstract
Macrolide resistance mechanisms can be target-based with a change in a 23S ribosomal RNA (rRNA) residue or a mutation in ribosomal protein L4 or L22 affecting the ribosome's interaction with the antibiotic. Alternatively, mono- or dimethylation of A2058 in domain V of the 23S rRNA by an acquired rRNA methyltransferase, the product of an erm (erythromycin ribosome methylation) gene, can interfere with antibiotic binding. Acquired genes encoding efflux pumps, most predominantly mef(A) + msr(D) in pneumococci/streptococci and msr(A/B) in staphylococci, also mediate resistance. Drug-inactivating mechanisms include phosphorylation of the 2'-hydroxyl of the amino sugar found at position C5 by phosphotransferases and hydrolysis of the macrocyclic lactone by esterases. These acquired genes are regulated by either translation or transcription attenuation, largely because cells are less fit when these genes, especially the rRNA methyltransferases, are highly induced or constitutively expressed. The induction of gene expression is cleverly tied to the mechanism of action of macrolides, relying on antibiotic-bound ribosomes stalled at specific sequences of nascent polypeptides to promote transcription or translation of downstream sequences.
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“The most common resistance mechanism involves methylation of the 23S rRNA component of the 50S ribosome, encoded by the erm(A) and erm(C) genes, which confer resistance to macrolides, lincosamides, and streptogramin B (MLS_B resistance) by preventing macrolide binding [262,263,264,265,266].”
From Staphylococcus aureus: A Review of the Pathogenesis and Virulence Mechanisms (2025) · cites this paper as [262]
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Cites
Pao, S. S., Paulsen, I. T., & Saier, M. H. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.1.1-34.1998 · Cited by 2,297
Crystal structure of the ribosome at 5.5 Å resolution
Yusupov, M. M., Yusupova, G. Z., Baucom, A., Lieberman, K., Earnest, T. N., Cate, J. H. D., & Noller, H. F. (2001) · Science · doi:10.1126/science.1060089 · Cited by 1,944
Ribosome-targeting antibiotics and mechanisms of bacterial resistance
Wilson, D. N. (2014) · Nature Reviews Microbiology · doi:10.1038/nrmicro3155 · Cited by 1,054
The A-Z of bacterial translation inhibitors
Wilson, D. N. (2009) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409230903307311 · Cited by 322
Molecular Mechanism of Drug-Dependent Ribosome Stalling
Vazquez-Laslop, N., Thum, C., & Mankin, A. S. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.02.026 · Cited by 260
SecM-Stalled Ribosomes Adopt an Altered Geometry at the Peptidyl Transferase Center
Bhushan, S., Hoffmann, T., Seidelt, B., Frauenfeld, J., Mielke, T., Berninghausen, O., Wilson, D. N., & Beckmann, R. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1000581 · Cited by 154
Stamm, L. V., & Bergen, H. L. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.3.806-807.2000 · Cited by 123
Divergent stalling sequences sense and control cellular physiology.
Ito, K., Chiba, S., & Pogliano, K. (2010) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2010.01.073 · Cited by 107
Cited by
Staphylococcus aureus: A Review of the Pathogenesis and Virulence Mechanisms
Touaitia, R., Mairi, A., Ibrahim, N. A., Basher, N. S., Idres, T., & Touati, A. (2025) · Antibiotics · doi:10.3390/antibiotics14050470 · Cited by 273
Lomakin, I. B., Devarkar, S. C., Patel, S., Grada, A., & Bunick, C. G. (2023) · Nucleic Acids Research · doi:10.1093/nar/gkad103 · Cited by 25
Mahmud, Z., Manik, M. R. K., Rahman, A., Karim, M. M., & Islam, L. N. (2024) · Scientific Reports · doi:10.1038/s41598-024-71472-6 · Cited by 22
McGaha, D. A., Collins, A., Ajisafe, L. O., Perdigao, C. C., Bondrowski, J. L., Fetsch, K., & Dunkle, J. A. (2025) · RNA · doi:10.1261/rna.080068.124
Metadata
- Authors
- Fyfe, C., Grossman, T. H., Kerstein, K., & Sutcliffe, J.
- Venue
- Cold Spring Harbor Perspectives in Medicine
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2016-08-15
- Volume
- 6
- Issue
- 10
- Pages
- a025395
- ISSN
- 2157-1422 (ISSN-L)
- OpenAlex
- W2509014851
- Cited by
- 246
- References
- 8
- Type
- posted content
- Language
- en
- Open access
- bronze
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- Fyfe, C., Grossman, T. H., Kerstein, K., & Sutcliffe, J. (2016). Resistance to Macrolide Antibiotics in Public Health Pathogens. Cold Spring Harbor Perspectives in Medicine. https://doi.org/10.1101/cshperspect.a025395
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
