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Structure of the Tfb1/p53 Complex: Insights into the Interaction between the p62/Tfb1 Subunit of TFIIH and the Activation Domain of p53
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“Thus, the interaction with p300 prevents the MDM2-mediated proteasomal degradation of p53. In contrast, binding to negative regulators (MDM2/4) inhibits the interaction of p300 with components of the transcription machinery.”
From p53: from understanding its structure to advances in therapeutic targeting (2026) · cites this paper as [19]
In the citing paper
“The TAD is a disordered binding region for a larger cohort of interacting proteins, including molecules involved in the transcriptional machinery, the negative regulators MDM2/4, and the transcriptional coactivators p300/CREB-binding protein (CBP).15,18,19”
From p53: from understanding its structure to advances in therapeutic targeting (2026) · cites this paper as [19]
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Cites
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DNA damage activates p53 through a phosphorylation–acetylation cascade
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Self-citationTranscriptional activation by recruitment
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Aromatic Rings in Chemical and Biological Recognition: Energetics and Structures
Salonen, L. M., Ellermann, M., & Diederich, F. (2011) · Angewandte Chemie International Edition · doi:10.1002/anie.201007560 · Cited by 1,539
Targeting p53 pathways: mechanisms, structures, and advances in therapy
Wang, H., Guo, M., Wei, H., & Chen, Y. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01347-1 · Cited by 1,016
Pathological Unfoldomics of Uncontrolled Chaos: Intrinsically Disordered Proteins and Human Diseases
Uversky, V. N., Davé, V., Iakoucheva, L. M., Malaney, P., Metallo, S. J., Pathak, R. R., & Joerger, A. C. (2014) · Chemical Reviews · doi:10.1021/cr400713r · Cited by 288
Cooperative regulation of p53 by modulation of ternary complex formation with CBP/p300 and HDM2
Ferreon, J. C., Lee, C. W., Arai, M., Martinez-Yamout, M. A., Dyson, H. J., & Wright, P. E. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811023106 · Cited by 210
Brzovic, P. S., Heikaus, C. C., Kisselev, L., Vernon, R., Herbig, E., Pacheco, D., Warfield, L., Littlefield, P., Baker, D., Klevit, R. E., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.11.008 · Cited by 203
Metadata
- Authors
- Di Lello, P., Jenkins, L. M. M., Jones, T. N., Nguyen, B. D., Hara, T., Yamaguchi, H., Dikeakos, J. D., Appella, E., Legault, P., & Omichinski, J. G.
- Venue
- Molecular Cell
- Publisher
- Elsevier BV
- Published
- 2006-06
- Volume
- 22
- Issue
- 6
- Pages
- 731-740
- ISSN
- 1097-2765
- Cited by
- 192
- References
- 10
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2639 d)
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- Di Lello, P., Jenkins, L. M. M., Jones, T. N., Nguyen, B. D., Hara, T., Yamaguchi, H., Dikeakos, J. D., Appella, E., Legault, P., & Omichinski, J. G. (2006). Structure of the Tfb1/p53 Complex: Insights into the Interaction between the p62/Tfb1 Subunit of TFIIH and the Activation Domain of p53. Molecular Cell. https://doi.org/10.1016/j.molcel.2006.05.007
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