The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development
Open accessAbstract
In vertebrate embryos, formation of anterior neural structures requires suppression of Wnt signals emanating from the paraxial mesoderm and midbrain territory. In Six3 −/− mice, the prosencephalon was severely truncated, and the expression of Wnt1 was rostrally expanded, a finding that indicates that the mutant head was posteriorized. Ectopic expression of Six3 in chick and fish embryos, together with the use of in vivo and in vitro DNA-binding assays, allowed us to determine that Six3 is a direct negative regulator of Wnt1 expression. These results, together with those of phenotypic rescue of headless/tcf3 zebrafish mutants by mouse Six3, demonstrate that regionalization of the vertebrate forebrain involves repression of Wnt1 expression by Six3 within the anterior neuroectoderm. Furthermore, these results support the hypothesis that a Wnt signal gradient specifies posterior fates in the anterior neural plate.
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Cites
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Self-citationDickkopf1 Is Required for Embryonic Head Induction and Limb Morphogenesis in the Mouse
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Forebrain gene expression domains and the evolving prosomeric model
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Self-citationPatterning and plasticity of the cerebral cortex
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WNTS in the vertebrate nervous system: from patterning to neuronal connectivity
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Evolution of eyes and photoreceptor cell types
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Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers
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Metadata
- Authors
- Lagutin, O. V., Zhu, C. C., Kobayashi, D., Topczewski, J., Shimamura, K., Puelles, L., Russell, H. R. C., McKinnon, P. J., Solnica-Krezel, L., & Oliver, G.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2003-01-22
- Volume
- 17
- Issue
- 3
- Pages
- 368-379
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2146111983
- Cited by
- 527
- References
- 37
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development. https://app.cochat.ai/papers/10.1101/gad.1059403
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- Lagutin, O. V., Zhu, C. C., Kobayashi, D., Topczewski, J., Shimamura, K., Puelles, L., Russell, H. R. C., McKinnon, P. J., Solnica-Krezel, L., & Oliver, G. (2003). Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development. Genes & Development. https://doi.org/10.1101/gad.1059403
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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