The DOI matches its Crossref record; 88 of the 88 references it cites were found in a registry or an index.
Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers
Abstract
Mouse embryos bearing hypomorphic and conditional null Fgf8mutations have small and abnormally patterned telencephalons. We provide evidence that the hypoplasia results from decreased Foxg1 expression,reduced cell proliferation and increased cell death. In addition, alterations in the expression of Bmp4, Wnt8b, Nkx2.1 and Shh are associated with abnormal development of dorsal and ventral structures. Furthermore, nonlinear effects of Fgf8 gene dose on the expression of a subset of genes, including Bmp4 and Msx1, correlate with a holoprosencephaly phenotype and with the nonlinear expression of transcription factors that regulate neocortical patterning. These data suggest that Fgf8 functions to coordinate multiple patterning centers, and that modifications in the relative strength of FGF signaling can have profound effects on the relative size and nature of telencephalic subdivisions.
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Self-citationAn Fgf8 mutant allelic series generated by Cre- and Flp-mediated recombination
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Self-citationOpposing BMP and EGF signalling pathways converge on the TGF-β family mediator Smad1
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Self-citationTbr1 regulates differentiation of the preplate and layer 6
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Self-citationBone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development
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Neocortex Patterning by the Secreted Signaling Molecule FGF8
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Self-citationNew insights into the development of the human cerebral cortex
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Metadata
- Authors
- Storm, E. E., Garel, S., Borello, U., Hebert, J. M., Martinez, S., McConnell, S. K., Martin, G. R., & Rubenstein, J. L. R.
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2006-05-01
- Volume
- 133
- Issue
- 9
- Pages
- 1831-1844
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W1970783808
- Cited by
- 366
- References
- 88
- FWCI
- 11.66
- Type
- journal article
- Language
- en
- Open access
- closed
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- Storm, E. E., Garel, S., Borello, U., Hebert, J. M., Martinez, S., McConnell, S. K., Martin, G. R., & Rubenstein, J. L. R. (2006). Dose-dependent functions of Fgf8 in regulating telencephalic patterning centers. Development. https://doi.org/10.1242/dev.02324
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
