The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy
Open accessAbstract
Rheumatoid arthritis (RA) is one of the most critical articular diseases with synovial hyperplasia followed by impairment of quality of life. However, the mechanism(s) that regulates synovial cell outgrowth is not fully understood. To clarify its mechanism(s), we carried out immunoscreening by using antirheumatoid synovial cell antibody and identified and cloned “Synoviolin/Hrd1”, an E3 ubiquitin ligase. Synoviolin/Hrd1 was highly expressed in the rheumatoid synovium, and mice overexpressing this enzyme developed spontaneous arthropathy. Conversely, synoviolin/hrd1 +/- mice were resistant to collagen-induced arthritis by enhanced apoptosis of synovial cells. We conclude that Synoviolin/Hrd1 is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its antiapoptotic effects. Our findings provide a new pathogenetic model of RA and suggest that Synoviolin/Hrd1 could be targeted as a therapeutic strategy for RA.
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Cites
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Friedlander, R., Jarosch, E., Urban, J., Volkwein, C., & Sommer, T. (2000) · Nature Cell Biology · doi:10.1038/35017001 · Cited by 474
Cited by
The Pathogenesis of Rheumatoid Arthritis
McInnes, I. B., & Schett, G. (2011) · New England Journal of Medicine · doi:10.1056/nejmra1004965 · Cited by 5,514
Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies
Guo, Q., Wang, Y., Xu, D., Nossent, J., Pavlos, N. J., & Xu, J. (2018) · Bone Research · doi:10.1038/s41413-018-0016-9 · Cited by 1,767
Mechanisms of Disease: the molecular and cellular basis of joint destruction in rheumatoid arthritis
Müller-Ladner, U., Pap, T., Gay, R. E., Neidhart, M., & Gay, S. (2005) · Nature Clinical Practice Rheumatology · doi:10.1038/ncprheum0047 · Cited by 334
Molecular and cellular basis of rheumatoid joint destruction
Karouzakis, E., Neidhart, M., Gay, R. E., & Gay, S. (2006) · Immunology Letters · doi:10.1016/j.imlet.2006.04.011 · Cited by 167
Nakamura, N., Shimaoka, Y., Tougan, T., Onda, H., Okuzaki, D., Zhao, H., Fujimori, A., Yabuta, N., Nagamori, I., Tanigawa, A., et al. (2006) · DNA Research · doi:10.1093/dnares/dsl006 · Cited by 94
Metadata
- Authors
- Amano, T., Yamasaki, S., Yagishita, N., Tsuchimochi, K., Shin, H., Kawahara, K.-I., Aratani, S., Fujita, H., Zhang, L., Ikeda, R., Fujii, R., Miura, N., Komiya, S., Nishioka, K., Maruyama, I., Fukamizu, A., & Nakajima, T.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2003-01-01
- Volume
- 17
- Issue
- 19
- Pages
- 2436-2449
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2097868610
- Cited by
- 270
- References
- 4
- Type
- posted content
- Language
- en
- Open access
- diamond
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- The paper
- Amano, T., Yamasaki, S., Yagishita, N., Tsuchimochi, K., Shin, H., Kawahara, K.-I., Aratani, S., Fujita, H., Zhang, L., Ikeda, R., Fujii, R., Miura, N., Komiya, S., Nishioka, K., Maruyama, I., Fukamizu, A., & Nakajima, T. (2003). Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy. Genes & Development. https://doi.org/10.1101/gad.1096603
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
