The DOI matches its Crossref record; 57 of the 71 references it cites were found in a registry or an index.
DNA damage induces phosphorylation of the amino terminus of p53
Open accessAbstract
Data are presented demonstrating that DNA damage leads to specific post-translational modifications of p53 protein. Using two-dimensional peptide mapping of in vivo radiolabeled p53 tryptic phosphopeptides, recombinant truncated p53 protein, and synthetic p53 tryptic peptides, a unique p53 phosphopeptide was identified after exposure of ML-1 cells to ionizing irradiation. This peptide represents the first 24 amino acids of p53 and contains three phosphorylated serine residues. A specific p53 phosphopeptide antibody identified serine-15 as one of the two serines in p53 that becomes phosphorylated following DNA damage induced by either ionizing irradiation (IR) or ultraviolet (UV) irradiation in multiple cell types. IR-induced phosphorylation of p53 does not affect the kinetics of p53 binding to or dissociating from DNA as assessed by electrophoretic mobility-shift assays. However, p53 phosphorylation induced by DNA damage correlates with enhanced transcription of downstream p53 target genes. Low levels of phosphoserine-15 p53 are detectable within 6 hr after IR in AT cells, whereas lymphoblasts from normal individuals exhibit this modification within 1 hr. In contrast, phosphorylation of p53 on serine-15 is similar in normal and AT cells after UV irradiation. Our results indicate that p53 is phosphorylated in response to DNA damage, that this de novo phosphorylation may be involved in the subsequent induction and activation of p53, and that although ATM affects the kinetics of p53 phosphorylation after IR, it is not absolutely required for phosphorylation of p53 on serine-15.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Doxorubicin treatment of early passage tumor cell lines revealed that five of five early generation mTerc Ink4a / Arf -/ -tumors maintained intact p53 response evidenced by p53 Ser-18 phosphorylation (37, 38) and associated induction of p21 CIP1 .”
From Ink4a / Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse (2007) · cites this paper as [38]
Experimental — accuracy not yet measuredIn the citing paper
“Induction of double strand breaks in DNA by ionizing radiation or genotoxic chemotherapy leads to the rapid stabilization of p53 through phosphorylation of its N terminus (Shieh et al. 1997; Siliciano et al. 1997”
From p53 Deficiency Rescues the Adverse Effects of Telomere Loss and Cooperates with Telomere Dysfunction to Accelerate Carcinogenesis (1999) · cites this paper as Siliciano et al. 1997
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
WAF1, a potential mediator of p53 tumor suppression
El-Deiry, W. S., Tokino, T., Velculescu, V. E., Levy, D. B., Parsons, R., Trent, J. M., Lin, D., Mercer, W. E., Kinzler, K. W., & Vogelstein, B. (1993) · Cell · doi:10.1016/0092-8674(93)90500-p · Cited by 8,321
Mdm2 promotes the rapid degradation of p53
Haupt, Y., Maya, R., Kazaz, A., & Oren, M. (1997) · Nature · doi:10.1038/387296a0 · Cited by 4,506
Participation of p53 protein in the cellular response to DNA damage.
Kastan, M. B., Onyekwere, O. C., Sidransky, D., Vogelstein, B., & Craig, R. W. (1991) · PubMed · Cited by 3,761
Self-citationRegulation of p53 stability by Mdm2
Kubbutat, M. H. G., Jones, S. N., & Vousden, K. H. (1997) · Nature · doi:10.1038/387299a0 · Cited by 3,312 · cited 1×
“It has been demonstrated recently that the mechanism for this inhibition involves binding Mdm2 to p53 and targeting p53 for rapid degradation (Haupt et al. 1997; Kubbutat et al. 1997).”
BackgroundDérijard, B., Hibi, M., Wu, I.-H., Barrett, T., Su, B., Deng, T., Karin, M., & Davis, R. J. (1994) · Cell · doi:10.1016/0092-8674(94)90380-8 · Cited by 3,188
Momand, J., Zambetti, G. P., Olson, D. C., George, D., & Levine, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90644-r · Cited by 3,113
Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047
Self-citationA Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase
Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., et al. (1995) · Science · doi:10.1126/science.7792600 · Cited by 2,785
Hartwell, L. H., & Kastan, M. B. (1994) · Science · doi:10.1126/science.7997877 · Cited by 2,539
Self-citationp53: puzzle and paradigm.Preprint
Ko, L. J., & Prives, C. L. (1996) · Genes & Development · doi:10.1101/gad.10.9.1054 · Cited by 2,346
Flagged first, then by citations
14 of the 71 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Items 101–200 of 815
ATM, a central controller of cellular responses to DNA damage
Khanna, K. K., Lavin, M. F., Jackson, S. P., & Mulhern, T. D. (2001) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4400874 · Cited by 260
p53 transcriptional activity is essential for p53‐dependent apoptosis following DNA damage
Chao, C., Saito, S., Kang, J., Anderson, C. W., Appella, E., & Xu, Y. (2000) · The EMBO Journal · doi:10.1093/emboj/19.18.4967 · Cited by 260
Self-citationKurz, E. U., Douglas, P., & Lees‐Miller, S. P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406879200 · Cited by 254
A subset of ATM‐ and ATR‐dependent phosphorylation events requires the BRCA1 protein
Foray, N., Marot, D., Gabriel, A., Randrianarison-Huetz, V., Carr, A. M., Perricaudet, M., Ashworth, A., & Jeggo, P. A. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg274 · Cited by 266
Role for ATM in DNA damage-induced phosphorylation of BRCA1.
Gatei, M. H., Scott, S. P., Filippovitch, I., Soronika, N., Lavin, M. F., Weber, B. L., & Khanna, K. K. (2000) · PubMed · Cited by 245
Sotiropoulou, P. A., Candi, A., Mascré, G., Clercq, S. D., Youssef, K. K., Lapouge, G., Dahl, E., Semeraro, C., Denecker, G., Marine, J., et al. (2010) · Nature Cell Biology · doi:10.1038/ncb2059 · Cited by 252
Lu, X., Nguyen, T., Moon, S.-H., Darlington, Y. F., Sommer, M., & Donehower, L. A. (2008) · Cancer and Metastasis Reviews · doi:10.1007/s10555-008-9127-x · Cited by 251
Mechanisms of switching on p53: a role for covalent modification?
Meek, D. W. (1999) · Oncogene · doi:10.1038/sj.onc.1202951 · Cited by 238
p53-Mdm2--the affair that never ends
Alarcon-Vargas, D. (2002) · Carcinogenesis · doi:10.1093/carcin/23.4.541 · Cited by 234
Friesner, J. D., Liu, B., Culligan, K. M., & Britt, A. (2005) · Molecular Biology of the Cell · doi:10.1091/mbc.e04-10-0890 · Cited by 233
Dial 9-1-1 for p53: Mechanisms of p53 Activation by Cellular Stress
Ljungman, M. E. (2000) · Neoplasia · doi:10.1038/sj.neo.7900073 · Cited by 222
Wang, H., Gao, X., Fukumoto, S., Tademoto, S., Sato, K., & Hirai, K. (1999) · Journal of Cellular Physiology · doi:10.1002/(sici)1097-4652(199911)181:2 · Cited by 45
Marples, B., Wouters, B. G., Collis, S. J., Chalmers, A. J., & Joiner, M. C. (2004) · Radiation Research · doi:10.1667/rr3130 · Cited by 221
DNA Damage Caused by Metal Nanoparticles: Involvement of Oxidative Stress and Activation of ATM
Wan, R., Mo, Y., Feng, L., Chien, S., Tollerud, D. J., & Zhang, Q. (2012) · Chemical Research in Toxicology · doi:10.1021/tx200513t · Cited by 209
p53 Signaling and Cell Cycle Checkpoints
Stewart, Z. A., & Pietenpol, J. A. (2001) · Chemical Research in Toxicology · doi:10.1021/tx000199t · Cited by 204
Dayal, S., Sparks, A., Jacob, J., Allende-Vega, N., Lane, D. P., & Saville, M. K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m805871200 · Cited by 203
Cellular UV damage responses—Functions of tumor suppressor p53
Latonen, L., & Laiho, M. (2005) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2005.04.003 · Cited by 200
The nucleolus: the magician’s hat for cell cycle tricks
Visintin, R., & Amon, A. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00102-2 · Cited by 196
Webley, K., Bond, J. A., Jones, C. J., Blaydes, J. P., Craig, A., Hupp, T., & Wynford-Thomas, D. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.8.2803-2808.2000 · Cited by 192
Stark, G. R., & Taylor, W. R. (2004) · Humana Press eBooks · doi:10.1385/1-59259-788-2:051 · Cited by 203
Kobet, E., Zeng, X., Zhu, Y., Keller, D., & Lu, H. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.23.12547 · Cited by 193
Juven‐Gershon, T., & Oren, M. (1999) · Molecular Medicine · doi:10.1007/bf03402141 · Cited by 193
Transcriptomic characterization of cold acclimation in larval zebrafish
Long, Y., Song, G., Yan, J., He, X., Li, Q. X., & Cui, Z. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-612 · Cited by 199
IκB-kinaseβ-dependent NF-κB activation provides radioprotection to the intestinal epithelium
Egan, L. J., Eckmann, L., Greten, F. R., Chae, S.-W., Li, Z.-W., Myhre, G. M., Robine, S., Karin, M., & Kagnoff, M. F. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0306734101 · Cited by 192
Gatei, M. H., Zhou, B. S., Hobson, K., Scott, S. P., Young, D., & Khanna, K. K. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011681200 · Cited by 190
Kudoh, A., Fujita, M., Zhang, L., Shirata, N., Daikoku, T., Sugaya, Y., Isomura, H., Nishiyama, Y., & Tsurumi, T. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m411405200 · Cited by 192
DNA Damage Responses: Mechanisms and Roles in Human Disease
Kastan, M. B. (2008) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-08-0020 · Cited by 198
Self-citationMutations in serines 15 and 20 of human p53 impair its apoptotic activity
Unger, T., Sionov, R. V., Moallem, E., Yee, C., Howley, P. M., Oren, M., & Haupt, Y. (1999) · Oncogene · doi:10.1038/sj.onc.1202656 · Cited by 190
Checkpoints: How to activate p53
Caspari, T. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00439-5 · Cited by 186
The p53 tumour suppressor gene
Steele, R. J., Thompson, A. M., Hall, P. A., & Lane, D. P. (1998) · British journal of surgery · doi:10.1046/j.1365-2168.1998.00910.x · Cited by 185
Regulation of p53 stability and activity in response to genotoxic stress
Colman, M. S., Afshari, C. A., & Barrett, J. C. (2000) · Mutation Research/Reviews in Mutation Research · doi:10.1016/s1383-5742(00)00035-1 · Cited by 182
Herráiz, C., Calvo, F., Pandya, P., Cantelli, G., Rodríguez‐Hernández, I., Orgaz, J. L., Kang, N., Chu, T., Sahai, E. A., & Sanz‐Moreno, V. (2015) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djv289 · Cited by 180
Radiation-Induced Senescence-like Growth Arrest Requires TP53 Function but not Telomere Shortening
Suzuki, K., Mori, I., Nakayama, Y., Miyakoda, M., Kodama, S., & Watanabe, M. (2001) · Radiation Research · doi:10.1667/0033-7587(2001)155[0248:rislga]2.0.co;2 · Cited by 177
hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage
Duckett, D. R., Bronstein, S. M., Taya, Y., & Modrich, P. L. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.22.12384 · Cited by 178
Self-citationJimenez, G. S., Khan, S. H., Stommel, J. M., & Wahl, G. M. (1999) · Oncogene · doi:10.1038/sj.onc.1203013 · Cited by 177
Candidate protein biodosimeters of human exposure to ionizing radiation
Marchetti, F., Coleman, M. A., Jones, I. M., & Wyrobek, A. J. (2006) · International Journal of Radiation Biology · doi:10.1080/09553000600930103 · Cited by 176
Targeting ATR and Chk1 kinases for cancer treatment: A new model for new (and old) drugs
Toledo, L. I., Murga, M., & Fernández-Capetillo, Ó. (2011) · Molecular Oncology · doi:10.1016/j.molonc.2011.07.002 · Cited by 180
The ATM signaling network in development and disease
Stracker, T. H., Roig, I., Knobel, P. A., & Marjanović, M. (2013) · Frontiers in Genetics · doi:10.3389/fgene.2013.00037 · Cited by 192
Dai, M., Sun, X., & Lu, H. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01662-07 · Cited by 174
Purification and DNA binding properties of the ataxia-telangiectasia gene product ATM
Smith, G. C. M., Cary, R. B., Lakin, N. D., Hann, B. C., Teo, S., Chen, D. J., & Jackson, S. P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.20.11134 · Cited by 173
Cao, C., Lü, S., Kivlin, R., Wallin, B., Card, E., Bagdasarian, A., Tamakloe, T., Wang, W., Song, X., Chu, W., et al. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00453.x · Cited by 171
DNA damage response pathway in radioadaptive response
Sasaki, M. S., Ejima, Y., Tachibana, A., Yamada, T., Ishizaki, K., Shimizu, T., & Nomura, T. (2002) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/s0027-5107(02)00084-2 · Cited by 166
Chemoresistance in human ovarian cancer: the role of apoptotic regulators
Fraser, M. E., Leung, B. M., Jahani‐Asl, A., Yan, X., Thompson, W. E., & Tsang, B. K. (2003) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-1-66 · Cited by 173
Stress-Dependent Nucleolin Mobilization Mediated by p53-Nucleolin Complex Formation
Daniely, Y., Dimitrova, D. D., & Borowiec, J. A. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.16.6014-6022.2002 · Cited by 174
The Transactivation Domains of the p53 ProteinPreprint
Raj, N., & Attardi, L. D. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a026047 · Cited by 178
Role of p53 Serine 46 in p53 Target Gene Regulation
Smeenk, L., van Heeringen, S. J., Koeppel, M., Gilbert, B., Janssen‐Megens, E. M., Stunnenberg, H. G., & Lohrum, M. A. E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017574 · Cited by 174
Blagosklonny, M. V. (2000) · The FASEB Journal · doi:10.1096/fj.99-1078rev · Cited by 170
Phosphorylation of murine p53 at Ser-18 regulates the p53 responses to DNA damage
Chao, C., Saito, S., Anderson, C. W., Appella, E., & Xu, Y. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.220252297 · Cited by 168
Self-citationRedox signalling and transition metals in the control of the p53 pathway
Méplan, C., Richard, M., & Hainaut, P. L. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00297-x · Cited by 164
Cortes-Bratti, X., Karlsson, C., Lagergård, T., Thelestam, M., & Frisan, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008527200 · Cited by 162
Choi, J., Nannenga, B., Demidov, O. N., Bulavin, D. V., Cooney, A. J., Brayton, C. F., Zhang, Y., Mbawuike, I. N., Bradley, A., Appella, E., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.4.1094-1105.2002 · Cited by 163
Self-citationCBP and p300 are cytoplasmic E4 polyubiquitin ligases for p53
Shi, D., Pop, M. S., Kulikov, R., Love, I. M., Kung, A. L., & Grossman, S. R. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904305106 · Cited by 165
The role of p53 in treatment responses of lung cancer
Viktorsson, K., Petris, L. D., & Lewensohn, R. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.03.192 · Cited by 161
López-Borges, S., & Lazo, P. A. (2000) · Oncogene · doi:10.1038/sj.onc.1203709 · Cited by 158
Wang, S., Guo, M. A., Ouyang, H., Li, X., Cordon‐Cardo, C., Kurimasa, A., Chen, D. J., FUKS, Z. Y., Ling, C., & Li, G. C. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.4.1584 · Cited by 162
Ellison, T. I., Smith, M. K., Gilliam, A. C., & MacDonald, P. N. (2008) · Journal of Investigative Dermatology · doi:10.1038/jid.2008.131 · Cited by 159
Ionizing radiation activates the ATM kinase throughout the cell cycle
Pandita, T. K., Lieberman, H. B., Lim, D., Dhar, S., Zheng, W., Taya, Y., & Kastan, M. B. (2000) · Oncogene · doi:10.1038/sj.onc.1203444 · Cited by 155
Self-citationPhosphorylation of Serine 18 Regulates Distinct p53 Functions in Mice
Sluss, H. K., Armata, H., Gallant, J., & Jones, S. N. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.3.976-984.2004 · Cited by 152
Protein Phosphatases Regulate DNA-dependent Protein Kinase Activity
Douglas, P., Moorhead, G. B. G., Ye, R., & Lees‐Miller, S. P. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m011703200 · Cited by 153
The dual role model for p53 in maintaining genomic integrity
Janus, F., Albrechtsen, N. J. W., Dornreiter, I., Wiesmüller, L., Große, F., & Deppert, W. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050266 · Cited by 154
Another fork in the road—life or death decisions by the tumour suppressor p53
Carvajal, L. A., & Manfredi, J. J. (2013) · The EMBO Reports · doi:10.1038/embor.2013.25 · Cited by 149
5-Aza-2′-deoxycytidine Activates the p53/p21Waf1/Cip1 Pathway to Inhibit Cell Proliferation
Zhu, W., Hileman, T., Ke, Y., Wang, P., Lu, S., Duan, W., Dai, Z., Tong, T., Villalona-Calero, M. A., Plass, C., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311703200 · Cited by 148
Chen, R., Qin, Z., Ren, M., Kanai, H., Chalecka-Franaszek, E., Leeds, P. R., & Chuang, D. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01548.x · Cited by 149
HIF‐1‐dependent transcriptional activity is required for oxygen‐mediated HIF‐1α degradation
Berra, E., Richard, D. E., Gothié, E., & Pouysségur, J. (2001) · FEBS Letters · doi:10.1016/s0014-5793(01)02159-7 · Cited by 147
p53 accumulates but is functionally impaired when DNA synthesis is blocked
Gottifredi, V., Shieh, S.-Y., Taya, Y., & Prives, C. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.3.1036 · Cited by 147
Self-citationStrategies for manipulating the p53 pathway in the treatment of human cancer
Hupp, T. R., Lane, D. P., & Ball, K. L. (2000) · Biochemical Journal · doi:10.1042/bj3520001 · Cited by 148
Cell-cycle checkpoint kinases: checking in on the cell cycle
Walworth, N. C. (2000) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00154-x · Cited by 146
Molecular aetiology and pathogenesis of basal cell carcinoma
Tilli, C. M. L. J., Steensel, M. A. M. V., Krekels, G. A. M., Neumann, H. A. M., & Ramaekers, F. C. S. (2005) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2005.06587.x · Cited by 145
Kim, J. M., Yoon, Y., & Tsang, B. K. (1999) · Endocrinology · doi:10.1210/en.140.5.2307 · Cited by 147
Soberanes, S., Urich, D., Baker, C. M., Burgess, Z., Chiarella, S. E., Bell, E. L., Ghio, A. J., Vizcaya‐Ruíz, A. D., Liu, J., Ridge, K. M., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m808844200 · Cited by 144
Direct involvement of p53 in the base excision repair pathway of the DNA repair machinery
Offer, H., Wolkowicz, R., Matas, D., Blumenstein, S., Livneh, Z., & Rotter, V. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00505-0 · Cited by 150
Pise-Masison, C. A., Mahieux, R., Jiang, H., Ashcroft, M. A., Radonovich, M. F., Duvall, J. F., Guillerm, C., & Brady, J. N. (2000) · Molecular and Cellular Biology · doi:10.1128/.20.10.3377-3386.2000 · Cited by 148
Arsenite induces p53 accumulation through an ATM-dependent pathway in human fibroblasts.
Yih, L., & Lee, T. (2000) · PubMed · Cited by 142
Kaelin, W. G. (1999) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/91.7.594 · Cited by 143
ATM Engages Autodegradation of the E3 Ubiquitin Ligase COP1 After DNA Damage
Dornan, D., Shimizu, H., Mah, A. S., Dudhela, T., Eby, M. T., O’Rourke, K. M., Seshagiri, S., & Dixit, V. M. (2006) · Science · doi:10.1126/science.1127335 · Cited by 145
Understanding p53 functions through p53 antibodies
Sabapathy, K., & Lane, D. P. (2019) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjz010 · Cited by 139
Turenne, G. A., & Price, B. D. (2001) · BMC Cell Biology · doi:10.1186/1471-2121-2-12 · Cited by 139
Cuddihy, A. R., Li, S., Tam, N. W. N., Wong, A. H., Taya, Y., Abraham, N., Bell, J. C., & Koromilas, A. E. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2475 · Cited by 137
Self-citationThe p53 protein family and radiation sensitivity: Yes or no?
Cuddihy, A. R., & Bristow, R. G. (2004) · Cancer and Metastasis Reviews · doi:10.1023/b:canc.0000031764.81141.e4 · Cited by 137
Shin, Y. C., Nakamura, H., Liang, X., Feng, P., Chang, H., Kowalik, T. F., & Jung, J. U. (2006) · Journal of Virology · doi:10.1128/jvi.80.5.2257-2266.2006 · Cited by 137
Lavin, M. F. (1999) · International Journal of Radiation Biology · doi:10.1080/095530099139359 · Cited by 137
Latonen, L., Taya, Y., & Laiho, M. (2001) · Oncogene · doi:10.1038/sj.onc.1204883 · Cited by 134
Self-citationPise-Masison, C. A., Radonovich, M. F., Sakaguchi, K., Appella, E., & Brady, J. N. (1998) · Journal of Virology · doi:10.1128/jvi.72.8.6348-6355.1998 · Cited by 134
Self-citationCovalent and noncovalent modifiers of the p53 protein
Jayaraman, L., & Prives, C. L. (1999) · Cellular and Molecular Life Sciences · doi:10.1007/s000180050271 · Cited by 132
The ataxia-telangiectasia related protein ATR mediates DNA-dependent phosphorylation of p53
Lakin, N. D., Hann, B. C., & Jackson, S. P. (1999) · Oncogene · doi:10.1038/sj.onc.1202973 · Cited by 135
Nakagawa, K., Taya, Y., Tamai, K., & Yamaizumi, M. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2828 · Cited by 134
Self-citationSuzuki, K., Kodama, S., & Watanabe, M. (2001) · PubMed · Cited by 130
Inhibition of ATR protein kinase activity by schisandrin B in DNA damage response
Nishida, H., Tatewaki, N., Nakajima, Y., Magara, T., Ko, K. M., Hamamori, Y., & Konishi, T. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkp593 · Cited by 133
Human p53 Is Phosphorylated on Serines 6 and 9 in Response to DNA Damage-inducing Agents
Higashimoto, Y., Saito, S., Tong, X., Hong, A. L., Sakaguchi, K., Appella, E., & Anderson, C. W. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002674200 · Cited by 128
Self-citationA High-Frequency Regulatory Polymorphism in the p53 Pathway Accelerates Tumor Development
Post, S. M., Quintás-Cardama, A., Pant, V., Iwakuma, T., Hamir, A., Jackson, J. G., Maccio, D. R., Bond, G. L., Johnson, D. G., Levine, A. J., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.07.010 · Cited by 127
Defective apoptosis and B-cell lymphomas in mice with p53 point mutation at Ser 23
MacPherson, D., Kim, J., Kim, T., Rhee, B. K., van Oostrom, C. T., DiTullio, R. A., Venere, M., Halazonetis, T. D., Bronson, R., de Vries, A., et al. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600363 · Cited by 124
Golding, S. E., Rosenberg, E., Khalil, A. A., McEwen, A., Holmes, M., Neill, S. J., Povirk, L. F., & Valerie, K. C. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m314191200 · Cited by 124
Activated oncogenes promote and cooperate with chromosomal instability for neoplastic transformationPreprint
Woo, R. A., & Poon, R. Y. C. (2004) · Genes & Development · doi:10.1101/gad.1165204 · Cited by 129
ATM-Deficient Colorectal Cancer Cells Are Sensitive to the PARP Inhibitor Olaparib
Wang, C., Jette, N., Moussienko, D., Bebb, D. G., & Lees‐Miller, S. P. (2017) · Translational Oncology · doi:10.1016/j.tranon.2017.01.007 · Cited by 125
Ariumi, Y., Kaida, A., Lin, J.-Y., Hirota, M., Masui, O., Yamaoka, S., Taya, Y., & Shimotohno, K. (2000) · Oncogene · doi:10.1038/sj.onc.1203450 · Cited by 123
Self-citationApoptosis Associated with Deregulated E2F Activity Is Dependent on E2F1 and Atm/Nbs1/Chk2
Rogoff, H. A., Pickering, M., Frame, F. M., Debatis, M. E., Sánchez, Y., Jones, S. N., & Kowalik, T. F. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.7.2968-2977.2004 · Cited by 123
Keeping an old friend under control: regulation of p53 stability
Kubbutat, M. H. G., & Vousden, K. H. (1998) · Molecular Medicine Today · doi:10.1016/s1357-4310(98)01260-x · Cited by 122
Purification and Characterization of ATM from Human Placenta
Chan, D. W., Son, S.-C., Block, W. D., Ye, R., Khanna, K. K., Wold, M. S., Douglas, P., Goodarzi, A. A., Pelley, J. L., Taya, Y., et al. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.11.7803 · Cited by 122
Self-citationRegulation of the MDM2-p53 Pathway by Ribosomal Protein L11 Involves a Post-ubiquitination Mechanism
Dai, M., Shi, D., Jin, Y., Sun, X., Zhang, Y., Grossman, S. R., & Lu, H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602596200 · Cited by 124
Regulation of cellular senescence via the FOXO 4‐p53 axis
Bourgeois, B. M. R., & Madl, T. (2018) · FEBS Letters · doi:10.1002/1873-3468.13057 · Cited by 124
Metadata
- Authors
- Siliciano, J. D., Canman, C. E., Taya, Y., Sakaguchi, K., Appella, E., & Kastan, M. B.
- Affiliations
- National Institutes of Health (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 1997-12-15
- Volume
- 11
- Issue
- 24
- Pages
- 3471-3481
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC316806
- OpenAlex
- W2149013144
- Cited by
- 818
- References
- 71
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 5 · 2023: 7 · 2022: 10 · 2021: 10 · 2020: 12 · 2019: 14 · 2018: 12 · 2017: 18 · 2016: 22 · 2015: 17 · 2014: 24 · 2013: 21 · 2012: 27
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- American Society of Hematology
- National Institutes of Health (ES05777)
- National Cancer Institute (CA71387, R01CA071387)
- National Institute of Environmental Health Sciences (R01ES005777, R37ES005777, ES05777)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › DNA Repair Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- p53, DNA damage response, ionizing radiation, UV irradiation, post-translational modification, ATM kinase, lymphoblasts
- MeSH terms
- Ataxia Telangiectasia, Binding Sites, Cells, Cultured, DNA, DNA Damage, Electrophoresis, Humans, Lymphocytes, Nuclear Proteins, Peptide Fragments, Phosphorylation, Protein Processing, Post-Translational, Proto-Oncogene Proteins, Serine, Ultraviolet Rays, Signal Transduction, Tumor Suppressor Protein p53, Cyclins, Cyclin-Dependent Kinase Inhibitor p21, Proto-Oncogene Proteins c-mdm2
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
