The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
GATA-3: an unexpected regulator of cell lineage determination in skin
Open accessAbstract
Multipotent skin stem cells give rise to epidermis and its appendages, including the hair follicle. The Lef-1/Tcf family of Wnt-regulated transcription factors plays a major role in specification of the hair shaft, but little is known about how the equally important hair channel, the inner root sheath (IRS), develops in concert to shape and guide the hair. In a microarray screen to search for transcriptional regulators of hair follicle morphogenesis, we identified GATA-3, a key regulator of T-cell lineage determination. Surprisingly, this transcription factor is essential for stem cell lineage determination in skin, where it is expressed at the onset of epidermal stratification and IRS specification in follicles.GATA-3-null/lacZ knock-in embryos can survive up to embryonic day 18.5 (E18.5), when they fail to form the IRS. Skin grafting unveiled additional defects in GATA-3-null hairs and follicles. IRS progenitors failed to differentiate, whereas cortical progenitors differentiated, but produced an aberrant hair structure. Curiously, some GATA-3-null progenitor cells expressed mixed IRS and hair shaft markers. Taken together, these findings place GATA-3 with Lef-1/Wnts at the crossroads of the IRS versus hair shaft cell fate decision in hair follicle morphogenesis. This newfound function for GATA-3 in skin development strengthens the parallels between the differentiation programs governing hair follicle and lymphocyte differentiation.
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Cites
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Self-citationInvolvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis
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Self-citationMolecular Mechanisms Regulating Hair Follicle Development
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Cited by
Capturing and profiling adult hair follicle stem cells
Morris, R. J., Liu, Y., Marles, L., Yang, Z., Trempus, C., Li, S., Lin, J. S., Sawicki, J. A., & Cotsarelis, G. (2004) · Nature Biotechnology · doi:10.1038/nbt950 · Cited by 1,283
Epidermal homeostasis: a balancing act of stem cells in the skin
Blanpain, C., & Fuchs, E. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2636 · Cited by 1,270
Self-citationThe Hair Follicle as a Dynamic Miniorgan
Schneider, M. R., Schmidt-Ullrich, R., & Paus, R. (2009) · Current Biology · doi:10.1016/j.cub.2008.12.005 · Cited by 1,119
Scratching the surface of skin development
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Self-citationGata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation
Asselin-Labat, M.-L., Sutherland, K. D., Barker, H., Thomas, R., Shackleton, M., Forrest, N. C., Hartley, L., Robb, L., Grosveld, F. G., van der Wees, J., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1530 · Cited by 840
Metadata
- Authors
- Kaufman, C. K., Zhou, P., Amalia Pasolli, H., Rendl, M., Bolotin, D., Lim, K.-C., Dai, X., Alegre, M.-L., & Fuchs, E.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2003-01-01
- Volume
- 17
- Issue
- 17
- Pages
- 2108-2122
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2171997622
- Cited by
- 344
- References
- 61
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Kaufman, C. K., Zhou, P., Amalia Pasolli, H., Rendl, M., Bolotin, D., Lim, K.-C., Dai, X., Alegre, M.-L., & Fuchs, E. (2003). GATA-3: an unexpected regulator of cell lineage determination in skin. Genes & Development. https://doi.org/10.1101/gad.1115203
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