The DOI matches its Crossref record; 74 of the 75 references it cites were found in a registry or an index.
The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease
Open accessAbstract
The ability to sense and respond to changes in oxygen is essential for the survival of prokaryotic and eukaryotic organisms. Oxygen-sensing mechanisms have been developed to maintain cell and tissue homeostasis, as well as to adapt to the chronic low-oxygen conditions found in diseases such as cancer. This report on the first Keystone Meeting on the Biology of Hypoxia will summarize our current understanding of key genes and pathways involved in oxygen sensing that are required for normal development and that are dysregulated in disease states. It will also comment on future directions for this exciting field.
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“While HIF signaling is essential for development and tissue homeostasis”
From HIF inhibition: Current strategies and clinical challenges (2026) · cites this paper as [27]
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Cites
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Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch
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Leva, G. D., Garofalo, M., & Croce, C. M. (2013) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012513-104715 · Cited by 1,705
Tumor angiogenesis and vascular normalization: alternative therapeutic targets
Viallard, C., & Larrivée, B. (2017) · Angiogenesis · doi:10.1007/s10456-017-9562-9 · Cited by 1,476
Du, R., Lu, K. V., Petritsch, C. K., Liu, P., Ganß, R., Passegue, E. A., Song, H., VandenBerg, S. R., Johnson, R. S., Werb, Z., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.01.034 · Cited by 1,166
Self-citationHypoxia-Induced Pulmonary Vascular Remodeling
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Metadata
- Authors
- Giaccia, A. J., Simon, M. C., & Johnson, R.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2004-09-15
- Volume
- 18
- Issue
- 18
- Pages
- 2183-2194
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC517513
- OpenAlex
- W2152395959
- Cited by
- 380
- References
- 75
- Citations by year
- 2026: 10 · 2025: 7 · 2024: 16 · 2023: 13 · 2022: 21 · 2021: 13 · 2020: 22 · 2019: 19 · 2018: 24 · 2017: 21 · 2016: 19 · 2015: 18 · 2014: 17 · 2013: 22 · 2012: 14
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Northwestern University
- Universität Zürich
- National Cancer Institute
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Kruppel-like factors research
- Keywords
- hypoxia, oxygen sensing, hypoxia-inducible factor, oxygen homeostasis, development (biology), cancer, disease, low oxygen environment, gene expression regulation
- MeSH terms
- Adaptation, Physiological, Animals, Hypoxia, Enzymes, Humans, Ion Channels, Mitochondria, Neoplasms, Oxygen, Reference Values, Protein Biosynthesis, Reactive Oxygen Species, Gene Expression Regulation, Developmental
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