Cited by 381Cancer, Hypoxia, and MetabolismRedox biology and oxidative stressKruppel-like factors research

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The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease

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Giaccia, Amato J., Simon, M. Celeste, Johnson, Randall·2004·Genes & Development

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Abstract

The ability to sense and respond to changes in oxygen is essential for the survival of prokaryotic and eukaryotic organisms. Oxygen-sensing mechanisms have been developed to maintain cell and tissue homeostasis, as well as to adapt to the chronic low-oxygen conditions found in diseases such as cancer. This report on the first Keystone Meeting on the Biology of Hypoxia will summarize our current understanding of key genes and pathways involved in oxygen sensing that are required for normal development and that are dysregulated in disease states. It will also comment on future directions for this exciting field.

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Authors: Giaccia, A. J., Simon, M. C., & Johnson, R.
Affiliations: Howard Hughes Medical Institute (US)
ORCID: Giaccia, Amato J.
Simon, M. Celeste
Johnson, Randall
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2004-09-15
Volume: 18
Issue: 18
Pages: 2183-2194
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.1243304
PMC: PMC517513
OpenAlex: W2152395959
Cited by: 380
References: 75
Citations by year: 2026: 10 · 2025: 7 · 2024: 16 · 2023: 13 · 2022: 21 · 2021: 13 · 2020: 22 · 2019: 19 · 2018: 24 · 2017: 21 · 2016: 19 · 2015: 18 · 2014: 17 · 2013: 22 · 2012: 14
Type: posted content
Language: en
Open access: bronze
doi.org
Locations: Genes & Development (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Northwestern University
Universität Zürich
National Cancer Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Kruppel-like factors research
Keywords: hypoxia, oxygen sensing, hypoxia-inducible factor, oxygen homeostasis, development (biology), cancer, disease, low oxygen environment, gene expression regulation
MeSH terms: Adaptation, Physiological, Animals, Hypoxia, Enzymes, Humans, Ion Channels, Mitochondria, Neoplasms, Oxygen, Reference Values, Protein Biosynthesis, Reactive Oxygen Species, Gene Expression Regulation, Developmental

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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

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