The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease

Targeting HIF-1 for cancer therapy

Semenza, G. L. (2003) · Nature Reviews Cancer · doi:10.1038/nrc1187 · Cited by 6,717

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180

Exploiting tumour hypoxia in cancer treatment

Brown, J. M., & Wilson, W. R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1367 · Cited by 2,828

Purification and Characterization of Hypoxia-inducible Factor 1

Wang, G. L., & Semenza, G. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.3.1230 · Cited by 2,094

Oxygen sensing by HIF hydroxylases

Schofield, C. J., & Ratcliffe, P. J. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1366 · Cited by 2,068

The CBP co-activator is a histone acetyltransferase

Bannister, A. J., & Kouzarides, T. (1996) · Nature · doi:10.1038/384641a0 · Cited by 1,828

Tumor Response to Radiotherapy Regulated by Endothelial Cell Apoptosis

Garcı́a-Barros, M., Paris, F., Cordon‐Cardo, C., Lyden, D. C., Rafii, S., Haimovitz‐Friedman, A., FUKS, Z. Y., & Kolesnick, R. (2003) · Science · doi:10.1126/science.1082504 · Cited by 1,591

Ubiquitination of hypoxia-inducible factor requires direct binding to the β-domain of the von Hippel–Lindau protein

Ohh, M., Park, C. W., Ivan, M., Hoffman, M. A., Kim, T.-Y., Huang, L. E., Pavletich, N., Chau, V., & Kaelin, W. G. (2000) · Nature Cell Biology · doi:10.1038/35017054 · Cited by 1,577

Asparagine Hydroxylation of the HIF Transactivation Domain: A Hypoxic Switch

Lando, D., Peet, D. J., Whelan, D. A., Gorman, J. J., & Whitelaw, M. L. (2002) · Science · doi:10.1126/science.1068592 · Cited by 1,558

FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor

Lando, D., Peet, D. J., Gorman, J. J., Whelan, D. A., Whitelaw, M. L., & Bruick, R. K. (2002) · Genes & Development · doi:10.1101/gad.991402 · Cited by 1,550

MicroRNAs in Cancer

Leva, G. D., Garofalo, M., & Croce, C. M. (2013) · Annual Review of Pathology Mechanisms of Disease · doi:10.1146/annurev-pathol-012513-104715 · Cited by 1,705

Tumor angiogenesis and vascular normalization: alternative therapeutic targets

Viallard, C., & Larrivée, B. (2017) · Angiogenesis · doi:10.1007/s10456-017-9562-9 · Cited by 1,476

HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion

Du, R., Lu, K. V., Petritsch, C. K., Liu, P., Ganß, R., Passegue, E. A., Song, H., VandenBerg, S. R., Johnson, R. S., Werb, Z., et al. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.01.034 · Cited by 1,166

Hypoxia-Induced Pulmonary Vascular Remodeling

Stenmark, K. R., Fagan, K. A., & Frid, M. G. (2006) · Circulation Research · doi:10.1161/01.res.0000243584.45145.3f · Cited by 1,001

MicroRNA-210 Modulates Endothelial Cell Response to Hypoxia and Inhibits the Receptor Tyrosine Kinase Ligand Ephrin-A3

Fasanaro, P., D'Alessandra, Y., Di Stefano, V., Melchionna, R., Romani, S., Pompilio, G., Capogrossi, M. C., & Martelli, F. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800731200 · Cited by 912

Hypoxia-inducible factor 1 and dysregulated c-Myc cooperatively induce vascular endothelial growth factor and metabolic switches hexokinase 2 and pyruvate dehydrogenase kinase 1

Kim, J.-W., Gao, P., Liu, Y.-C., Semenza, G. L., & Dang, C. V. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00440-07 · Cited by 658

MiRNA-Directed Regulation of VEGF and Other Angiogenic Factors under Hypoxia

Zhong, H., Lv, Q., Ye, W., Wong, C.-K. A., Cai, G., Gu, D., Ji, Y., Zhao, C., Wang, J., Yang, B. B., et al. (2006) · PLoS ONE · doi:10.1371/journal.pone.0000116 · Cited by 659

SUMO-Specific Protease 1 Is Essential for Stabilization of HIF1α during Hypoxia

Cheng, J., Kang, X., Zhang, S., & Yeh, E. T. H. (2007) · Cell · doi:10.1016/j.cell.2007.08.045 · Cited by 624

Gene Expression Programs in Response to Hypoxia: Cell Type Specificity and Prognostic Significance in Human Cancers

Chi, J., Wang, Z., Nuyten, D. S. A., Rodriguez, E. H., Schaner, M. E., Salim, A., Wang, Y., Kristensen, G. B., Helland, Å., Børresen‐Dale, A., et al. (2006) · PLoS Medicine · doi:10.1371/journal.pmed.0030047 · Cited by 625

Secretion of vascular endothelial growth factor by primary human fibroblasts at senescence

Coppé, J.-P., Kauser, K., Campisi, J., & Beauséjour, C. M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603307200 · Cited by 604

Regulation of angiogenesis by hypoxia-inducible factor 1

Hirota, K., & Semenza, G. L. (2006) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2005.12.003 · Cited by 473

Acute postnatal ablation of Hif-2 α results in anemia

Gruber, M., Hu, C.-J., Johnson, R. S., Brown, E. J., Keith, B., & Simon, M. C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608382104 · Cited by 457

Regulation of Osteogenesis-Angiogenesis Coupling by HIFs and VEGF

Schipani, E., Maes, C., Carmeliet, G., & Semenza, G. L. (2009) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.090602 · Cited by 416

The N-Terminal Transactivation Domain Confers Target Gene Specificity of Hypoxia-inducible Factors HIF-1α and HIF-2α

Hu, C.-J., Sataur, A., Wang, L., Chen, H., & Simon, M. C. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-05-0419 · Cited by 355

Side Effects of Radiographic Contrast Media: Pathogenesis, Risk Factors, and Prevention

Andreucci, M., Solomon, R., & Tasanarong, A. (2014) · BioMed Research International · doi:10.1155/2014/741018 · Cited by 353

Regulation of the Pulmonary Circulation in the Fetus and Newborn

Gao, Y., & Raj, J. U. (2010) · Physiological Reviews · doi:10.1152/physrev.00032.2009 · Cited by 357

Hypoxia-driven pathways in bone development, regeneration and disease

Maes, C., Carmeliet, G., & Schipani, E. (2012) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2012.36 · Cited by 306

Culture of human mesenchymal stem cells at low oxygen tension improves growth and genetic stability by activating glycolysis

Estrada, J. C., Albo, C., Benguría, A., Dopazo, A., López-Romero, P., Carrera-Quintanar, L., Roche, E., Clemente, E. P., Enríquez, J. A., Bernad, A., et al. (2012) · Cell Death & Differentiation · doi:10.1038/cdd.2011.172 · Cited by 297

Bacterial community morphogenesis is intimately linked to the intracellular redox state

Dietrich, L. E. P., Okegbe, C., Price-Whelan, A., Sakhtah, H., Hunter, R. C., & Newman, D. K. (2013) · Journal of Bacteriology · doi:10.1128/jb.02273-12 · Cited by 291

Oxygen-dependent diseases in the retina: Role of hypoxia-inducible factors

Arjamaa, O., & Nikinmaa, M. (2006) · Experimental Eye Research · doi:10.1016/j.exer.2006.01.016 · Cited by 275

Sensing and Signalling in Response to Oxygen Deprivation in Plants and Other Organisms

Bailey-Serres, J. N., & Chang, R. (2005) · Annals of Botany · doi:10.1093/aob/mci206 · Cited by 277

Endothelial cell metabolism in health and disease: impact of hypoxia

Wong, B. W., Marsch, E., Treps, L., Baes, M. I., & Carmeliet, P. (2017) · The EMBO Journal · doi:10.15252/embj.201696150 · Cited by 286

Differential Regulation of the Transcriptional Activities of Hypoxia-Inducible Factor 1 Alpha (HIF-1α) and HIF-2α in Stem Cells

Hu, C., Iyer, S. R., Sataur, A., Covello, K. L., Chodosh, L. A., & Simon, M. C. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.9.3514-3526.2006 · Cited by 270

The Hypoxic Testicle: Physiology and Pathophysiology

Reyes, J. G., Farías, J. G., Henríquez-Olavarrieta, S., Eva Madrid, A., Párraga, M., Zepeda, A. B., & Moreno, R. D. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/929285 · Cited by 239

Redox signaling in cardiovascular health and disease

Madamanchi, N. R., & Runge, M. S. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.04.001 · Cited by 227

The Progress and Promise of Molecular Imaging Probes in Oncologic Drug Development

Kelloff, G. J., Krohn, K. A., Larson, S. M., Weissleder, R., Mankoff, D. A., Hoffman, J. M., Link, J. M., Guyton, K. Z., Eckelman, W. C., Scher, H. I., et al. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1302 · Cited by 223

Signalling via the hypoxia-inducible factor-1α requires multiple posttranslational modifications

Brahimi‐Horn, C., Mazure, N. M., & Pouysségur, J. (2004) · Cellular Signalling · doi:10.1016/j.cellsig.2004.04.010 · Cited by 222

Hif-1α regulates differentiation of limb bud mesenchyme and joint development

Provot, S., Zinyk, D. L., Güneş, Y., Kathri, R., Le, Q., Kronenberg, H. M., Johnson, R. S., Longaker, M. T., Giaccia, A. J., & Schipani, E. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200612023 · Cited by 207

Hypoxia response and microRNAs: no longer two separate worlds

Ivan, M., Harris, A. L., Martelli, F., & Kulshreshtha, R. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00398.x · Cited by 198

Early fetal hypoxia leads to growth restriction and myocardial thinning

Ream, M. A., Ray, A. M., Chandra, R., & Chikaraishi, D. M. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00771.2007 · Cited by 191

HIF-2 complex dissociation, target inhibition, and acquired resistance with PT2385, a first-in-class HIF-2 inhibitor, in patients with clear cell renal cell carcinoma

Courtney, K. D., Ma, Y., Diaz de Leon, A., Christie, A., Xie, Z., Woolford, L., Singla, N., Joyce, A., Hill, H., Madhuranthakam, A. J., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-1459 · Cited by 188

Redox regulation of cellular functions

Oktyabrsky, O. N., & Smirnova, G. V. (2007) · Biochemistry (Moscow) · doi:10.1134/s0006297907020022 · Cited by 183

Hypoxic Tumor Microenvironment and Cancer Cell Differentiation

Kim, Y., Lin, Q., Glazer, P. M., & Yun, Z. (2009) · Current Molecular Medicine · doi:10.2174/156652409788167113 · Cited by 185

Myeloid Cells in the Tumor Microenvironment: Modulation of Tumor Angiogenesis and Tumor Inflammation

Schmid, M. C., & Varner, J. A. (2010) · Journal of Oncology · doi:10.1155/2010/201026 · Cited by 191

Crosstalk between Hypoxia and ER Stress Response: a Key Regulator of Macrophage Polarization

Díaz-Bulnes, P., Saiz, M. L., López-Larrea, C., & Rodríguez, R. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02951 · Cited by 175

Acute Kidney Injury by Radiographic Contrast Media: Pathogenesis and Prevention

Andreucci, M., Faga, T., Pisani, A., Sabbatini, M., & Michael, A. (2014) · BioMed Research International · doi:10.1155/2014/362725 · Cited by 171

Diagnostic and prognostic gene expression signatures in 177 soft tissue sarcomas: hypoxia-induced transcription profile signifies metastatic potential

Francis, P., Namløs, H. M., Müller, C., Edén, P., Fernebro, J., Berner, J., Bjerkehagen, B., Åkerman, M., Bendahl, P., Isinger-Ekstrand, A., et al. (2007) · BMC Genomics · doi:10.1186/1471-2164-8-73 · Cited by 169

Molecular Analysis of Tumor Margins by MALDI Mass Spectrometry in Renal Carcinoma

Oppenheimer, S. R., Mi, D., Sanders, M. E., & Caprioli, R. M. (2010) · Journal of Proteome Research · doi:10.1021/pr900936z · Cited by 172

Transcriptional Profiling of Human Cord Blood CD133+ and Cultured Bone Marrow Mesenchymal Stem Cells in Response to Hypoxia

Martin‐Rendon, E., Hale, S. J. M., Ryan, D. J., Baban, D. F., Forde, S. P., Roubelakis, M. G., Sweeney, D., Moukayed, M., Harris, A. L., Davies, K. E., et al. (2006) · Stem Cells · doi:10.1634/stemcells.2006-0398 · Cited by 167

Nitric Oxide Modulates Oxygen Sensing by Hypoxia-inducible Factor 1-dependent Induction of Prolyl Hydroxylase 2

Berchner‐Pfannschmidt, U., Yamac, H., Trinidad, B., & Fandrey, J. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607065200 · Cited by 158

The VHL tumor suppressor and HIF: insights from genetic studies in mice

Kapitsinou, P. P., & Haase, V. H. (2008) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402313 · Cited by 151

Current Strategies to Enhance Adipose Stem Cell Function: An Update

Seo, Y., Shin, T., & Kim, H. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20153827 · Cited by 149

Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxia

Bartoszewska, S., & Collawn, J. F. (2020) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-020-00212-1 · Cited by 152

Hypoxia, HIFs and bone development

Araldi, E., & Schipani, E. (2010) · Bone · doi:10.1016/j.bone.2010.04.606 · Cited by 153

Histone acetylation and DNA methylation in ischemia/reperfusion injury

Tang, J., & Zhuang, S. (2019) · Clinical Science · doi:10.1042/cs20180465 · Cited by 145

Adaptive Myogenesis under Hypoxia

Yun, Z., Lin, Q., & Giaccia, A. J. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.8.3040-3055.2005 · Cited by 146

Hypoxia-Inducible Factor-1 (HIF-1): A Potential Target for Intervention in Ocular Neovascular Diseases

Vadlapatla, R. K., Vadlapudi, A. D., & Mitra, A. K. (2013) · Current Drug Targets · doi:10.2174/13894501113149990015 · Cited by 148

Two transactivation mechanisms cooperate for the bulk of HIF‐1‐responsive gene expression

Kasper, L. H., Boussouar, F., Boyd, K. L., Xu, W., Biesen, M. A., Rehg, J. E., Baudino, T. A., Cleveland, J. L., & Brindle, P. K. (2005) · The EMBO Journal · doi:10.1038/sj.emboj.7600846 · Cited by 140

Critical role for NF‐κB‐induced JunB in VEGF regulation and tumor angiogenesis

Schmidt, D., Textor, B., Pein, O. T., Licht, A. H., Andrecht, S., Sator‐Schmitt, M., Fusenig, N. E., Angel, P. E., & Schorpp‐Kistner, M. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601539 · Cited by 139

Lactic Acidosis Triggers Starvation Response with Paradoxical Induction of TXNIP through MondoA

Chen, J. L.-Y., Merl, D., Peterson, C. W., Wu, J., Liu, P. Y., Yin, H., Muoio, D. M., Ayer, D. E., West, M., & Chi, J. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1001093 · Cited by 136

Hypoxia-Induced Endothelial Proliferation Requires Both mTORC1 and mTORC2

Li, W., Petrimpol, M., Molle, K. D., Hall, M. N., Battegay, E., & Humar, R. (2006) · Circulation Research · doi:10.1161/01.res.0000253094.03023.3f · Cited by 138

Cytokines and the regulation of hypoxia-inducible factor (HIF)-1α

Haddad, J. J., & Harb, H. L. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.11.009 · Cited by 139

Antenatal Steroids and Antioxidant Enzyme Activity in Preterm Infants: Influence of Gender and Timing

Vento, M., Aguar, M., Escobar, J., Arduini, A., Escrig, R., Brugada, M., Izquierdo, I., Asensi, M. A., Sastre, J., Sáenz, P., et al. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2671 · Cited by 129

CD24 Is an Effector of HIF-1–Driven Primary Tumor Growth and Metastasis

Thomas, S., Harding, M. A., Smith, S. C., Overdevest, J. B., Nitz, M. D., Frierson, H. F., Tomlins, S. A., Kristiansen, G., & Theodorescu, D. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3666 · Cited by 128

Oxygen Sensing Difluoroboron β-Diketonate Polylactide Materials with Tunable Dynamic Ranges for Wound Imaging

DeRosa, C. A., Seaman, S. A., Mathew, A. S., Gorick, C. M., Fan, Z., Demas, J. N., Peirce, S. M., & Fraser, C. L. (2016) · ACS Sensors · doi:10.1021/acssensors.6b00533 · Cited by 121

The irradiated tumor microenvironment: role of tumor-associated macrophages in vascular recovery

Russell, J. S., & Brown, J. M. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2013.00157 · Cited by 122

Tetramethylpyrazine reverses high-glucose induced hypoxic effects by negatively regulating HIF-1α induced BNIP3 expression to ameliorate H9c2 cardiomyoblast apoptosis

Liu, S., Shibu, M. A., Tsai, F., Hsu, Y., Tsai, C., Chung, J., Yang, J., Tang, C., Wang, S., Li, Q., et al. (2020) · Nutrition & Metabolism · doi:10.1186/s12986-020-0432-x · Cited by 121

Metformin induces CD11b+-cell-mediated growth inhibition of an osteosarcoma: implications for metabolic reprogramming of myeloid cells and anti-tumor effects

Uehara, T., Eikawa, S., Nishida, M., Kunisada, Y., Yoshida, A., Fujiwara, T., Kunisada, T., Ozaki, T., & Udono, H. (2018) · International Immunology · doi:10.1093/intimm/dxy079 · Cited by 120

HIF-Dependent Hematopoietic Factors Regulate the Development of the Embryonic Vasculature

Ramírez‐Bergeron, D. L., Runge, A., Adelman, D. M., Gohil, M., & Simon, M. C. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.04.018 · Cited by 115

Current Understanding of Hypoxia in Glioblastoma Multiforme and Its Response to Immunotherapy

Park, J. H., & Lee, H. K. (2022) · Cancers · doi:10.3390/cancers14051176 · Cited by 117

Adipose Tissue-specific Inhibition of Hypoxia-inducible Factor 1α Induces Obesity and Glucose Intolerance by Impeding Energy Expenditure in Mice*

Zhang, X., Lam, K. S. L., Ye, H., Chung, S. K., Zhou, M., Wang, Y., & Xu, A. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.135509 · Cited by 112

VEGF-independent cell-autonomous functions of HIF-1α regulating oxygen consumption in fetal cartilage are critical for chondrocyte survival

Maes, C., Araldi, E., Haigh, K., Khatri, R., Looveren, R. V., Giaccia, A. J., Haigh, J. J., Carmeliet, G., & Schipani, E. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1487 · Cited by 118

Hypoxia: From Placental Development to Fetal Programming

Fajersztajn, L., & Veras, M. M. (2017) · Birth Defects Research · doi:10.1002/bdr2.1142 · Cited by 122

Hypoxia-induced GBE1 expression promotes tumor progression through metabolic reprogramming in lung adenocarcinoma

Li, L., Yang, L., Fan, Z., Xue, W., Shen, Z., Yuan, Y., Sun, X., Wang, D., Lian, J., Wang, L., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-0152-8 · Cited by 111

Hypoxia and HIF-1α in chondrogenesis

Schipani, E. (2005) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2005.03.003 · Cited by 110

Impact of the hypoxic tumor microenvironment on the regulation of cancer stem cell characteristics

Lin, Q., & Yun, Z. (2010) · Cancer Biology & Therapy · doi:10.4161/cbt.9.12.12347 · Cited by 108

Prevention of Contrast-Induced Nephropathy through a Knowledge of Its Pathogenesis and Risk Factors

Andreucci, M., Faga, T., Pisani, A., Sabbatini, M., Russo, D., & Michael, A. (2014) · The Scientific World JOURNAL · doi:10.1155/2014/823169 · Cited by 105

Adaptation to oxygen deprivation in cultures of human pluripotent stem cells, endothelial progenitor cells, and umbilical vein endothelial cells

Abaci, H. E., Truitt, R., Luong, E., Drazer, G., & Gerecht, S. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00484.2009 · Cited by 108

Evolution of Nanoparticle-Mediated Photodynamic Therapy: From Superficial to Deep-Seated Cancers

Sivasubramanian, M., Chuang, Y.-C., & Lo, L. (2019) · Molecules · doi:10.3390/molecules24030520 · Cited by 101

Potentiation of Glucocorticoid Activity in Hypoxia through Induction of the Glucocorticoid Receptor

Leonard, M. O., Godson, C., Brady, H. R., & Taylor, C. T. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.4.2250 · Cited by 100

Epigenetic Regulation of BMP7 in the Regenerative Response to Ischemia

Marumo, T., Hishikawa, K., Yoshikawa, M., & Fujita, T. (2008) · Journal of the American Society of Nephrology · doi:10.1681/asn.2007091040 · Cited by 98

Gene therapy to enhance angiogenesis in chronic wounds

Shaabani, E., Sharifiaghdam, M., Majidi, R. F., Smedt, S. C. D., Braeckmans, K., & Fraire, J. C. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2022.08.020 · Cited by 101

Nutrient and Metabolic Sensing in T Cell Responses

Wei, J., Raynor, J. L., Nguyen, T.-L. M., & Chi, H. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00247 · Cited by 101

Electron-shuttling antibiotics structure bacterial communities by modulating cellular levels of c-di-GMP

Okegbe, C., Fields, B. L., Cole, S. J., Beierschmitt, C., Morgan, C. J., Price‐Whelan, A., Stewart, R. C., Lee, V. T., & Dietrich, L. E. P. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1700264114 · Cited by 91

HO-3867, a safe STAT3 inhibitor, is selectively cytotoxic to ovarian cancer

Rath, K. S., Naidu, S. K., Lata, P., Bid, H. K., Rivera, B. K., McCann, G. A., Tierney, B. J., ElNaggar, A. C., Bravo, V., Leone, G., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2433 · Cited by 95

Cochlear Pericyte Responses to Acoustic Trauma and the Involvement of Hypoxia-Inducible Factor-1α and Vascular Endothelial Growth Factor

Shi, X. (2009) · American Journal Of Pathology · doi:10.2353/ajpath.2009.080739 · Cited by 87

The Hypoxia-Inducible Factor and Tumor Progression Along the Angiogenic Pathway

Brahimi-Horn, M. C., & Pouysségur, J. (2004) · International review of cytology · doi:10.1016/s0074-7696(04)42004-x · Cited by 87

Effects of Severe Hypoxia on Bone Marrow Mesenchymal Stem Cells Differentiation Potential

Cicione, C., Muiños-López, E., Hermida-Gómez, T., Fuentes-Boquete, I., Díaz-Prado, S., & Blanco, F. J. (2013) · Stem Cells International · doi:10.1155/2013/232896 · Cited by 84

A Phase I Study of the Safety and Pharmacokinetics of the Hypoxia-Activated Prodrug TH-302 in Combination with Doxorubicin in Patients with Advanced Soft Tissue Sarcoma

Ganjoo, K. N., Cranmer, L. D., Butrynski, J. E., Rushing, D. A., Adkins, D., Okuno, S. H., Lorente, G., Kroll, S., Langmuir, V. K., & Chawla, S. P. (2011) · Oncology · doi:10.1159/000327739 · Cited by 81

Update on the renal toxicity of iodinated contrast drugs used in clinical medicine

Andreucci, M., Faga, T., Serra, R., Sarro, G. D., & Michael, A. (2017) · Drug Healthcare and Patient Safety · doi:10.2147/dhps.s122207 · Cited by 80

Hypoxia-Induced Signaling in the Cardiovascular System

Simon, M. C., Liu, L., Barnhart, B. C., & Young, R. M. (2007) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100526 · Cited by 82

Differential effects of chronic intermittent and chronic constant hypoxia on postnatal growth and development

Farahani, R., Kanaan, A., Gavrialov, O., Brunnert, S. R., Douglas, R. M., Morcillo, P., & Haddad, G. G. (2007) · Pediatric Pulmonology · doi:10.1002/ppul.20729 · Cited by 76

Transcriptional up‐regulation of FoxM1 in response to hypoxia is mediated by HIF‐1

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Endothelial dysfunction in individuals born after fetal growth restriction: cardiovascular and renal consequences and preventive approaches

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