The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
PAF1-complex-mediated histone methylation of FLOWERING LOCUS C chromatin is required for the vernalization-responsive, winter-annual habit in Arabidopsis
Open accessAbstract
The winter-annual habit (which typically involves a requirement for exposure to the cold of winter to flower in the spring) in Arabidopsis thaliana is mainly due to the repression of flowering by relatively high levels of FLC expression. Exposure to prolonged cold attenuates FLC expression through a process known as vernalization and thus permits flowering to occur in the spring. Here we show that the elevated FLC expression characteristic of nonvernalized winter annuals requires two genes, EARLY FLOWERING 7 (ELF7) and EARLY FLOWERING 8 (ELF8), that are homologs of components of the PAF1 complex of Saccharomyces cerevisiae. Furthermore, ELF7 and ELF8 are also required for the expression of other genes in the FLC clade of flowering repressors such as MAF2 and FLM. FLC, FLM, and MAF2 are involved in multiple flowering pathways that account for the broad effects of elf7 and elf8 mutations on flowering behavior. ELF7 and ELF8 are required for the enhancement of histone 3 trimethylation at Lys 4 in FLC chromatin. This modification of FLC chromatin appears to be required to elevate FLC expression to levels that can delay flowering in plants that have not been vernalized. A model of the role of ELF7, ELF8, and other previously described genes in the modification of the chromatin of flowering repressors is presented.
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1 retracted
Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1
Beisel, C., Imhof, A., Greene, J., Kremmer, E., & Sauer, F. (2002) · Nature · doi:10.1038/nature01126 · Cited by 310
RetractedGenome-Wide Insertional Mutagenesis of Arabidopsis thaliana
Alonso, J. M., Stepanova, A. N., Leisse, T. J., Kim, C. J., Chen, H., Shinn, P., Stevenson, D. K., Zimmerman, J., Barajas, P., Cheuk, R., et al. (2003) · Science · doi:10.1126/science.1086391 · Cited by 5,102
Active Genes Are Tri-Methylated at K4 of Histone H3
Santos-Rosa, H., Schneider, R., Bannister, A. J., Sherriff, J., Bernstein, B. E., Emre, N. C. T., Schreiber, S. L., Mellor, J., & Kouzarides, T. (2002) · Nature · doi:10.1038/nature01080 · Cited by 2,138
FLOWERING LOCUS C Encodes a Novel MADS Domain Protein That Acts as a Repressor of Flowering
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Self-citationNg, H. H., Robert, F., Young, R. A., & Struhl, K. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00092-3 · Cited by 1,095
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Self-citationVernalization requires epigenetic silencing of FLC by histone methylation
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Vernalization in Arabidopsis thaliana is mediated by the PHD finger protein VIN3
Sung, S., & Amasino, R. M. (2004) · Nature · doi:10.1038/nature02195 · Cited by 896
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Zhu, B., Zheng, Y., Pham, A.-D., Mandal, S. S., Erdjument-Bromage, H., Tempst, P., & Reinberg, D. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.09.025 · Cited by 532
What Has Natural Variation Taught Us about Plant Development, Physiology, and Adaptation?
Alonso-Blanco, C., Aarts, M. G. M., Bentsink, L., Keurentjes, J. J. B., Reymond, M., Vreugdenhil, D., & Koornneef, M. (2009) · The Plant Cell · doi:10.1105/tpc.109.068114 · Cited by 478
Keurentjes, J. J. B., Fu, J., Terpstra, I. R., Garcia, J. M., van den Ackerveken, G., Snoek, L. B., Peeters, A. J. M., Vreugdenhil, D., Koornneef, M., & Jansen, R. C. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610429104 · Cited by 340
Xu, L., Zhao, Z., Dong, A., Soubigou-Taconnat, L., Renou, J.-P., Steinmetz, A., & Shen, W.-H. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01607-07 · Cited by 329
Metadata
- Authors
- He, Y., Doyle, M. R., & Amasino, R. M.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2004-11-01
- Volume
- 18
- Issue
- 22
- Pages
- 2774-2784
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2137608671
- Cited by
- 334
- References
- 45
- Type
- posted content
- Language
- en
- Open access
- diamond
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- CoChat. (2026). Citation check: PAF1-complex-mediated histone methylation of FLOWERING LOCUS C chromatin is required for the vernalization-responsive, winter-annual habit in Arabidopsis. https://app.cochat.ai/papers/10.1101/gad.1244504
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- He, Y., Doyle, M. R., & Amasino, R. M. (2004). PAF1-complex-mediated histone methylation of FLOWERING LOCUS C chromatin is required for the vernalization-responsive, winter-annual habit in Arabidopsis. Genes & Development. https://doi.org/10.1101/gad.1244504
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