The DOI matches its Crossref record; 78 of the 79 references it cites were found in a registry or an index.
Coordination and communication between the p53 and IGF-1–AKT–TOR signal transduction pathways
Open accessAbstract
Over the past 10 years the signal transduction networks for p53, IGF-1-AKT, and TOR pathways have been assembled in worms, flies, and mammals, and their functions elucidated. In the past 1-2 years a number of genes and their proteins have been identified that permit extensive communication and coordination between these pathways. These three pathways are involved in sensing and integrating signals arising from nutrient and growth factor availability, signals from sensory and sexual organs, and intrinsic and extrinsic stress signals. In turn these pathways regulate cell growth, proliferation, and death. These networks are central to our understanding of a variety of physiological and pathological conditions, including cancer, diabetes, and longevity.
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“Furthermore, reports showed that p53 activation is able to inhibit the activity of mTOR through a pathway involving the subsequent activation of TSC gene products TSC1 and TSC2, which are tumour suppressors and negative regulators of mTOR [78, 103–105].”
From PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease (2009) · cites this paper as [104]
In the citing paper
“There is a growing awareness that, as far as the cell is concerned, sensing nutrient availability and energetic status is an integrated and 'system biology' endeavour 101 .”
From The common biology of cancer and ageing (2007) · cites this paper as [101]
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“Overall lifespan seems to be influenced by many of these sensors and effectors, indicating that there is an intimate connection between energy sensing and longevity 101 .”
From The common biology of cancer and ageing (2007) · cites this paper as [101]
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p53, the cellular gatekeeper for growth and division
Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693
Self-citationVogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607 · cited 2×
“These include DNA damage and telomere shortening, hypoxia, low nucleoside triphosphate pool sizes, spindle damage, heat and cold shock, inflammation and nitric oxide production, as well as oncogene activation by mutations (Levine 1997; Vogelstein et al. 2000; Jin and Levine 2001).”
BackgroundSelf-citationPhosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
Sarbassov, D. D., Guertin, D. A., Ali, S. M., & Sabatini, D. M. (2005) · Science · doi:10.1126/science.1106148 · Cited by 6,216
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., & Greenberg, M. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80405-5 · Cited by 5,689
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., & Greenberg, M. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80595-4 · Cited by 5,594
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
Vassilev, L. T., Vu, B. T., Graves, B., Carvajal, D., Podlaski, F., Filipovic, Z., Kong, N., Kammlott, U., Lukacs, C., Klein, C., et al. (2004) · Science · doi:10.1126/science.1092472 · Cited by 4,661
Cancer genes and the pathways they control
Vogelstein, B., & Kinzler, K. W. (2004) · Nature Medicine · doi:10.1038/nm1087 · Cited by 4,346
Upstream and downstream of mTOR
Hay, N., & Sonenberg, N. (2004) · Genes & Development · doi:10.1101/gad.1212704 · Cited by 4,181
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914
Blume-Jensen, P., & Hunter, T. (2001) · Nature · doi:10.1038/35077225 · Cited by 3,738
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Items 101–200 of 321
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Papazoglu, C., & Mills, A. (2007) · The Journal of Pathology · doi:10.1002/path.2086 · Cited by 75
Jeong, B., Hu, W., Белый, В. А., Rabadán, R., & Levine, A. J. (2009) · The FASEB Journal · doi:10.1096/fj.09-146001 · Cited by 72
Self-citationCottage, C. T., Peterson, N., Kearley, J., Berlin, A., Xiong, X., Huntley, A., Zhao, W., Brown, C., Migneault, A., Zerrouki, K., et al. (2019) · Communications Biology · doi:10.1038/s42003-019-0532-1 · Cited by 71
Imaging of tumor glucose utilization with positron emission tomography
Bürkle, A., & Weber, W. (2008) · Cancer and Metastasis Reviews · doi:10.1007/s10555-008-9151-x · Cited by 72
Moriishi, T., Maruyama, Z., Fukuyama, R., Ito, M., Miyazaki, T., Kitaura, H., Ohnishi, H., Furuichi, T., Kawai, Y., Masuyama, R., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027487 · Cited by 68
Özkan, E. E. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.07.002 · Cited by 67
REVIEW PAPER: Origin and Molecular Pathology of Adrenocortical Neoplasms
Bielińska, M., Parviainen, H., Kiiveri, S., Heikinheimo, M., & Wilson, D. B. (2009) · Veterinary Pathology · doi:10.1354/vp.08-vp-0179-w-rev · Cited by 68
Liu, Z., Thornton, J., Špı́rek, M., & Butow, R. A. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00929-07 · Cited by 66
Li, Q., Ceylan‐Isik, A. F., Li, J., & Ren, J. T. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0717 · Cited by 67
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Rapaka, D., Bitra, V. R., Challa, S. R., & Adiukwu, P. C. (2022) · Neurochemistry International · doi:10.1016/j.neuint.2022.105311 · Cited by 65
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Lee, J. H., Bodmer, R., Bier, E., & Karin, M. (2010) · Aging · doi:10.18632/aging.100157 · Cited by 65
Deisenroth, C., & Zhang, Y. (2011) · Genes & Cancer · doi:10.1177/1947601911409737 · Cited by 68
Amino Acid Regulation of Autophagosome Formation
Meijer, A. J. (2008) · Methods in molecular biology · doi:10.1007/978-1-59745-157-4_5 · Cited by 64
TFF1 activates p53 through down-regulation of miR-504 in gastric cancer
Soutto, M., Chen, Z., Saleh, M. A., Katsha, A. M., Zhu, S., Zaika, A. I., Belkhiri, A., & El-Rifai, W. M. (2014) · Oncotarget · doi:10.18632/oncotarget.2156 · Cited by 61
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Álvarez-García, Ó., CARBAJO-PEREZ, E., Garcı́a, E., Gil, H., Molinos, I., Rodrı́guez, J., Ordóñez, F. Á., & Santos, F. (2007) · Pediatric Nephrology · doi:10.1007/s00467-007-0456-8 · Cited by 61
Autophagy, reactive oxygen species and the fate of mammalian cells
Szumiel, I. (2010) · Free Radical Research · doi:10.3109/10715762.2010.525233 · Cited by 61
mTOR inhibition acts as an unexpected checkpoint in p53-mediated tumor suppressionPreprint
Kon, N., Ou, Y., Wang, S.-J., Li, H., Rustgi, A. K., & Gu, W. J. (2020) · Genes & Development · doi:10.1101/gad.340919.120 · Cited by 59
Briganti, S., Flori, E., Mastrofrancesco, A., Kovacs, D., Camera, E., Ludovici, M., Cardinali, G., & Picardo, M. (2012) · Experimental Dermatology · doi:10.1111/exd.12066 · Cited by 60
Hasskarl, J. (2014) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-642-54490-3_23 · Cited by 63
Singh, R. K., Gaikwad, S. M., Jinager, A., Chaudhury, S., Maheshwari, A., & Ray, P. (2014) · Cancer Letters · doi:10.1016/j.canlet.2014.08.023 · Cited by 58
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Werner, H., Sarfstein, R., LeRoith, D., & Bruchim, I. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00159 · Cited by 59
Werner, H., & Sarfstein, R. (2014) · Growth Hormone & IGF Research · doi:10.1016/j.ghir.2014.03.006 · Cited by 57
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Lago, C. U., Sung, H. J., Ma, W., Wang, P., & Hwang, P. M. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3650 · Cited by 57
Soulard, A., & Hall, M. N. (2007) · Cell · doi:10.1016/j.cell.2007.04.010 · Cited by 58
Characterization of Nuclear Sirtuins: Molecular Mechanisms and Physiological Relevance
Toiber, D., Sebastián, C., & Mostoslavsky, R. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-21631-2_9 · Cited by 57
King, E. R., Zu, Z., Tsang, Y. T. M., Deavers, M. T., Malpica, A. L., Mok, S. C., Gershenson, D. M., & Wong, K. (2011) · Gynecologic Oncology · doi:10.1016/j.ygyno.2011.06.016 · Cited by 56
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Siroky, B. J., Yin, H. J., & Bissler, J. J. (2010) · Pediatric Nephrology · doi:10.1007/s00467-010-1689-5 · Cited by 55
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Hu, C.-A. A., Williams, D. B., Zhaorigetu, S., Khalil, S., Wan, G., & Valle, D. L. (2008) · Amino Acids · doi:10.1007/s00726-008-0107-9 · Cited by 55
Xiong, Y., Cao, F., Hu, L., Yan, C., Chen, L., Panayi, A. C., Sun, Y. T., Zhou, W., Zhang, P., Wu, Q., et al. (2019) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2019.06.001 · Cited by 54
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Shen, C., & Houghton, P. J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220898110 · Cited by 50
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Hay, N. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.08.010 · Cited by 52
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Ribeiro, D. L., Pinto‐Fochi, M. E., Rafacho, A., Bosqueiro, J. R., Maeda, S. Y., Anselmo‐Franci, J. A., Taboga, S. R., & Góes, R. M. (2012) · Journal of Andrology · doi:10.2164/jandrol.111.016089 · Cited by 52
Shukla, S., MacLennan, G. T., Fu, P., & Gupta, S. (2011) · Pharmaceutical Research · doi:10.1007/s11095-011-0625-0 · Cited by 52
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Geoffroy, C. G., Meves, J. M., & Zheng, B. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.11.003 · Cited by 50
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Sathyanarayana, P., Menon, M. P., Bogacheva, O., Bogachev, O., Niß, K., Kapelle, W. S., Houde, E., Fang, J., & Wojchowski, D. M. (2007) · Blood · doi:10.1182/blood-2006-11-056465 · Cited by 52
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Gallagher, E. J., Fierz, Y., Ferguson, R. D., & LeRoith, D. (2010) · Endocrine Practice · doi:10.4158/ep10098.ra · Cited by 50
Xiong, L., Kou, F., Yang, Y., & Wu, J. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200703044 · Cited by 51
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Milisav, I., Poljšak, B., & Ribarič, S. (2016) · APOPTOSIS · doi:10.1007/s10495-016-1317-3 · Cited by 49
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Xu, X., Hueckstaedt, L. K., & Ren, J. T. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.03.037 · Cited by 47
Huang, W., Chiu, H., Liao, T., Chuang, K., Shih, W.-L., & Liu, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133699 · Cited by 47
Anderson, C. W., & Appella, E. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00264-3 · Cited by 49
Huang, W., Chiu, H., Liao, T., Chuang, K., Shih, W.-L., & Liu, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0138627 · Cited by 46
Strategic Role for Mitochondria in Alzheimer's Disease and Cancer
Hedskog, L., Zhang, S., & Ankarcrona, M. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4259 · Cited by 45
Zou, W., Yang, S., Zhang, T., Sun, H., Wang, Y., Xue, H., & Zhou, D. (2014) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-014-0627-1 · Cited by 44
Lack of Bcl11b tumor suppressor results in vulnerability to DNA replication stress and damages
Kamimura, K., Mishima, Y., Obata, M., Endo, T., Aoyagi, Y., & Kominami, R. (2007) · Oncogene · doi:10.1038/sj.onc.1210388 · Cited by 45
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Grimberg, A., Coleman, C. M., Shi, Z., Burns, T. F., MacLachlan, T. K., Wang, W., & El‐Deiry, W. S. (2006) · Cancer Biology & Therapy · doi:10.4161/cbt.5.10.3455 · Cited by 44
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Oh, H., Oh, S. K., Lee, J. S., Wu, C., & Lee, S. (2017) · Food Science and Biotechnology · doi:10.1007/s10068-017-0236-6 · Cited by 42
Jeong, W., Song, G., Bazer, F., & Kim, J. (2014) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2014.01.023 · Cited by 38
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Wu, X., Ansari, A. R., Pang, X.-X., Li, H., Zhang, Z.-W., Luo, Y., Arshad, M. I., & Song, H. (2019) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-019-00544-7 · Cited by 39
O’Shaughnessy, R. F. L., Welti, J. C., Sully, K., & Byrne, C. R. (2009) · Development · doi:10.1242/dev.037010 · Cited by 39
Kelly, P., Bailey, C. L., Fueger, P. T., Newgard, C. B., Casey, P. J., & Kimple, M. E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.069112 · Cited by 39
Lai, L., Lilley, B. N., Sanes, J. R., & McMahon, A. P. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1309001110 · Cited by 39
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Telomerase activity promotes osteoblast differentiation by modulating IGF-signaling pathway
Saeed, H., Qiu, W., Chen, L., Flyvbjerg, A., Abdallah, B. M., & Kassem, M. S. (2015) · Biogerontology · doi:10.1007/s10522-015-9596-6 · Cited by 38
Attias-Geva, Z., Bentov, I., Kidron, D., Amichay, K., Sarfstein, R., Fishman, A., Bruchim, I., & Werner, H. (2011) · European Journal of Cancer · doi:10.1016/j.ejca.2011.09.014 · Cited by 38
Arvisais, E. W., Hou, X., Wyatt, T. A., Shirasuna, K., Bollwein, H., Miyamoto, A., Hansen, T. R., Rueda, B. R., & Davis, J. S. (2010) · Molecular Endocrinology · doi:10.1210/me.2009-0312 · Cited by 39
Manikandan, M., Rao, A. K. D. M., Arunkumar, G., Seenivasagam, R. K., Rajaraman, R., & Munirajan, A. K. (2015) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2015.16.17.7619 · Cited by 38
Smith, G. R., & Shanley, D. P. (2010) · PLoS ONE · doi:10.1371/journal.pone.0011092 · Cited by 40
Woldt, E., Matz, R. L., Terrand, J., Mlih, M., Gracia, C., Foppolo, S., Martin, S., Bruban, V., Ji, J. Y., Velot, É., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.212878 · Cited by 36
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Longo, V. D., Lieber, M. R., & Vijg, J. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2526 · Cited by 36
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Santiago, J. A., Scherzer, C. R., & Potashkin, J. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109042 · Cited by 35
Yilmaz, Ö. H., & Morrison, S. J. (2008) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2008.02.004 · Cited by 37
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Morel, M., Couturier, J., Pontcharraud, R., Gil, R., Fauconneau, B., Paccalin, M., & Page, G. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.07.004 · Cited by 36
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Hinkal, G. W., & Donehower, L. A. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.02.005 · Cited by 33
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Goswami, S. K., & Das, D. K. (2006) · PubMed Central · Cited by 34
Rios-Fuller, T. J., Mahé, M., Walters, B., Abbadi, D., Pérez-Baos, S., Gadi, A., Andrews, J. J., Katsara, O., Vincent, C. T., & Schneider, R. J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155301 · Cited by 34
Transcription‐blocking DNA damage in aging: a mechanism for hormesis
Schumacher, B. (2009) · BioEssays · doi:10.1002/bies.200900107 · Cited by 33
Aaltonen, K. E., Rosendahl, A. H., Olsson, H., Malmström, P., Hartman, L. W., & Fernö, M. (2014) · BMC Cancer · doi:10.1186/1471-2407-14-794 · Cited by 32
Davaadelger, B., Duan, L., Perez, R. E., Gitelis, S., & Maki, C. G. (2016) · Oncotarget · doi:10.18632/oncotarget.8484 · Cited by 32
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Kawakita, K., Nishiyama, T., Fujishiro, T., Hayashi, S., Kanzaki, N., Hashimoto, S., Takebe, K., Iwasa, K., Sakata, S., Nishida, K. K., et al. (2012) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2012.08.022 · Cited by 31
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Chao, S. K., Horwitz, S. B., & McDaid, H. M. (2011) · Oncotarget · doi:10.18632/oncotarget.221 · Cited by 30
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Leontieva, O. V., Novototskaya, L. R., Paszkiewicz, G., Komarova, E. A., Gudkov, A. V., & Blagosklonny, M. V. (2013) · Cancer Biology & Therapy · doi:10.4161/cbt.26947 · Cited by 30
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Othman, E. M., Hintzsche, H., & Stopper, H. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.12.010 · Cited by 31
Park, K.-S., Mitra, A., Rahat, B., Kim, K. K., & Pfeifer, K. E. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx896 · Cited by 30
Metabolic Syndrome, Type 2 Diabetes, and Cancer: Epidemiology and Potential Mechanisms
Ben-Shmuel, S., Rostoker, R., Scheinman, E. J., & LeRoith, D. (2015) · Handbook of experimental pharmacology · doi:10.1007/164_2015_12 · Cited by 31
Yashin, A. I., Wu, D., Arbeev, K. G., & Ukraintseva, S. V. (2012) · Rejuvenation Research · doi:10.1089/rej.2011.1257 · Cited by 29
Yin, M., Guan, X., Liao, Z. X., & Wei, Q. (2009) · PubMed Central · Cited by 29
Jeong, W., Kim, J., Bazer, F. W., & Song, G. (2014) · Biology of Reproduction · doi:10.1095/biolreprod.113.115873 · Cited by 28
Fukuoka, C. Y., Simões, A., Uchiyama, T., Arana-Chavez, V. E., Abiko, Y., Kuboyama, N., & BHAWAL, U. K. (2017) · PLoS ONE · doi:10.1371/journal.pone.0169443 · Cited by 27
Puurand, M., Peet, N., Piirsoo, A., Peetsalu, M., Soplepmann, J., Sirotkina, M., Peetsalu, A., Hemminki, A., & Seppet, E. K. (2012) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-012-1399-3 · Cited by 26
Zhang, Y., Zhou, X., Cheng, L., Wang, X., Zhang, Q., Zhang, Y., & Sun, S. (2019) · Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics · doi:10.3727/096504019x15668125347026 · Cited by 26
Intermediary metabolism: An intricate network at the crossroads of cell fate and function
Ferreira, L. M. R., Li, A. M., Serafim, T. L., Sobral, M. C. M., Alpoim, M. C., & Urbano, A. M. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165887 · Cited by 27
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Metadata
- Authors
- Levine, A. J., Feng, Z., Mak, T. W., You, H., & Jin, S.
- Affiliations
- University of Toronto (CA)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2006-02-01
- Volume
- 20
- Issue
- 3
- Pages
- 267-275
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2136212424
- Cited by
- 321
- References
- 79
- Citations by year
- 2025: 3 · 2024: 5 · 2023: 2 · 2022: 9 · 2021: 6 · 2020: 9 · 2019: 14 · 2018: 6 · 2017: 14 · 2016: 11 · 2015: 13 · 2014: 23 · 2013: 18 · 2012: 33
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- p53 pathway, TOR signaling, signaling pathways, pathway integration, nutrient sensing, growth factor signaling, stress signaling, cell growth and proliferation, apoptosis, cancer, diabetes mellitus, longevity
- MeSH terms
- Animals, Enzyme Activation, Humans, Insulin-Like Growth Factor I, Models, Biological, Multienzyme Complexes, Protein Kinases, Signal Transduction, Tumor Suppressor Protein p53, Oncogene Protein v-akt, Forkhead Transcription Factors, TOR Serine-Threonine Kinases
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