The DOI matches its Crossref record; 78 of the 79 references it cites were found in a registry or an index.
Coordination and communication between the p53 and IGF-1–AKT–TOR signal transduction pathways
Open accessAbstract
Over the past 10 years the signal transduction networks for p53, IGF-1-AKT, and TOR pathways have been assembled in worms, flies, and mammals, and their functions elucidated. In the past 1-2 years a number of genes and their proteins have been identified that permit extensive communication and coordination between these pathways. These three pathways are involved in sensing and integrating signals arising from nutrient and growth factor availability, signals from sensory and sexual organs, and intrinsic and extrinsic stress signals. In turn these pathways regulate cell growth, proliferation, and death. These networks are central to our understanding of a variety of physiological and pathological conditions, including cancer, diabetes, and longevity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Furthermore, reports showed that p53 activation is able to inhibit the activity of mTOR through a pathway involving the subsequent activation of TSC gene products TSC1 and TSC2, which are tumour suppressors and negative regulators of mTOR [78, 103–105].”
From PKR, the double stranded RNA‐dependent protein kinase as a critical target in Alzheimer's disease (2009) · cites this paper as [104]
In the citing paper
“There is a growing awareness that, as far as the cell is concerned, sensing nutrient availability and energetic status is an integrated and 'system biology' endeavour 101 .”
From The common biology of cancer and ageing (2007) · cites this paper as [101]
In the citing paper
“Overall lifespan seems to be influenced by many of these sensors and effectors, indicating that there is an intimate connection between energy sensing and longevity 101 .”
From The common biology of cancer and ageing (2007) · cites this paper as [101]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
p53, the cellular gatekeeper for growth and division
Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693
Self-citationVogelstein, B., Lane, D., & Levine, A. J. (2000) · Nature · doi:10.1038/35042675 · Cited by 6,607 · cited 2×
“These include DNA damage and telomere shortening, hypoxia, low nucleoside triphosphate pool sizes, spindle damage, heat and cold shock, inflammation and nitric oxide production, as well as oncogene activation by mutations (Levine 1997; Vogelstein et al. 2000; Jin and Levine 2001).”
BackgroundSelf-citationPhosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
Sarbassov, D. D., Guertin, D. A., Ali, S. M., & Sabatini, D. M. (2005) · Science · doi:10.1126/science.1106148 · Cited by 6,216
Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
Datta, S. R., Dudek, H., Tao, X., Masters, S., Fu, H., Gotoh, Y., & Greenberg, M. E. (1997) · Cell · doi:10.1016/s0092-8674(00)80405-5 · Cited by 5,689
Akt Promotes Cell Survival by Phosphorylating and Inhibiting a Forkhead Transcription Factor
Brunet, A., Bonni, A., Zigmond, M. J., Lin, M. Z., Juo, P., Hu, L. S., Anderson, M. J., Arden, K. C., Blenis, J., & Greenberg, M. E. (1999) · Cell · doi:10.1016/s0092-8674(00)80595-4 · Cited by 5,594
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
Vassilev, L. T., Vu, B. T., Graves, B., Carvajal, D., Podlaski, F., Filipovic, Z., Kong, N., Kammlott, U., Lukacs, C., Klein, C., et al. (2004) · Science · doi:10.1126/science.1092472 · Cited by 4,661
Cancer genes and the pathways they control
Vogelstein, B., & Kinzler, K. W. (2004) · Nature Medicine · doi:10.1038/nm1087 · Cited by 4,346
Upstream and downstream of mTOR
Hay, N., & Sonenberg, N. (2004) · Genes & Development · doi:10.1101/gad.1212704 · Cited by 4,181
TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914
Blume-Jensen, P., & Hunter, T. (2001) · Nature · doi:10.1038/35077225 · Cited by 3,738
Flagged first, then by citations
1 of the 79 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- 10.1172/JCI200320039 · DOI · Paper page
Cited by
Sorted by citations
Items 301–321 of 321
Overvloed en onbehagen. Uitdagingen voor de moderne endocrinologie.
Smit, J. W. A. (2008) · Leiden Repository (Leiden University)
Oxidative Stress‐Mediated Signaling Pathways by Environmental Stressors
Sone, H., & Akanuma, H. (2011) · Wiley eBooks · doi:10.1002/9781118148143.ch13
Ferreira, A. R. (2013) · Americanae (AECID Library)
Spodoptera frugiperda FKBP‐46 is a consensus p53 motif binding protein
Mohareer, K., Sahdev, S., & Hasnain, S. E. (2012) · Journal of Cellular Biochemistry · doi:10.1002/jcb.24429
NF-κB and p38 MAPK: Major regulators in skeletal muscle development
Ma, Y., Zhang, Y., & Zhu, Y. (2012) · International Conference on Information Technology in Medicine and Education · doi:10.1109/itime.2012.6291353
IRS-1 and SOCS2 are key regulators of insulin-like growth factor signaling in intestinal cancer
Ramocki, N. M. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/3cjy-a678
Dobson, C. C. (2014) · QSpace (Queen's University Library)
Efeito da proteína E6 do papilomavírus humano (HPV) nas vias de regulação da apoptose.
Lino, V. D. S. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/d.42.2016.tde-08092016-141842
Death Shapes Life: Characterizing the Role of p63 and p73 During Neural Development and Aging
Dugani, S. (2011) · TSpace (University of Toronto)
The Role of the Retinoblastoma Protein Family in Skeletal Myogenesis
Ciavarra, G. (2011) · Library and Archives Canada (Government of Canada)
Control of Adult Bone Marrow Erythroid Progenitor Cell Fate by Combinatorial Niche Factor Signals
Wang, W. (2012) · TSpace (University of Toronto)
Fukuoka, C. Y. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.23.2016.tde-04102016-153052
Dong, W., Zhao, Y., Cao, H., Wu, Z., & Du, J. (2017) · Oncotarget · doi:10.18632/oncotarget.21566
Intercellular Signaling Network Underlies Biological Time Across Multiple Temporal ScalesPreprint
Millstein, J., Summa, K. C., Yang, X., Zhu, J., Mi, H., Vitaterna, M. H., Turek, F. W., & Zhang, B. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/315788
New insight into the role of MDMX in MDM2-mediated p53 degradation and anti-cancer drug development
Yang, J., & Zhang, Y. (2021) · Oncoscience · doi:10.18632/oncoscience.542
Altered Signal Transduction Pathways in Melanoma
Chéli, Y., Lau, E. K., & Ronai, Z. A. (2017) · Springer eBooks · doi:10.1007/978-3-319-41319-8_7
Association of breast cancer and diabetes mellitus in Korean postmenopausal womenPreprint
Kim, B., Han, J. H., Kwak, H. Y., Kwon, K. Y., & Kim, J. H. (2020) · Research Square · doi:10.21203/rs.3.rs-79379/v1
The Increased Risk of Cancer in Obesity and Type 2 Diabetes: Potential Mechanisms
Gallagher, E. J., Neel, B. A., Antoniou, I. M., & LeRoith, D. (2016) · Springer eBooks · doi:10.1007/978-3-319-20797-1_36-1
The p53 Master Regulator and Rules of Engagement with Target Sequences
Inga, A., Jordan, J. J., Menéndez, D., Sanctis, V. D., & Resnick, M. A. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00265-5
Metadata
- Authors
- Levine, A. J., Feng, Z., Mak, T. W., You, H., & Jin, S.
- Affiliations
- University of Toronto (CA)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2006-02-01
- Volume
- 20
- Issue
- 3
- Pages
- 267-275
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2136212424
- Cited by
- 321
- References
- 79
- Citations by year
- 2025: 3 · 2024: 5 · 2023: 2 · 2022: 9 · 2021: 6 · 2020: 9 · 2019: 14 · 2018: 6 · 2017: 14 · 2016: 11 · 2015: 13 · 2014: 23 · 2013: 18 · 2012: 33
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- p53 pathway, TOR signaling, signaling pathways, pathway integration, nutrient sensing, growth factor signaling, stress signaling, cell growth and proliferation, apoptosis, cancer, diabetes mellitus, longevity
- MeSH terms
- Animals, Enzyme Activation, Humans, Insulin-Like Growth Factor I, Models, Biological, Multienzyme Complexes, Protein Kinases, Signal Transduction, Tumor Suppressor Protein p53, Oncogene Protein v-akt, Forkhead Transcription Factors, TOR Serine-Threonine Kinases
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
