The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
daf-12 encodes a nuclear receptor that regulates the dauer diapause and developmental age in C. elegans
Open accessAbstract
The daf-12 gene acts at the convergence of pathways regulating larval diapause, developmental age, and adult longevity in Caenorhabditis elegans. It encodes a nuclear receptor most closely related to two C. elegans receptors, NHR-8 and NHR-48,Drosophila DHR96, and vertebrate vitamin D and pregnane-X receptors.daf-12 has three predicted protein isoforms, two of which contain DNA- and ligand-binding domains, and one of which contains the ligand-binding domain only. Mutations cluster in DNA- and ligand-binding domains, but correspond to distinct phenotypic classes. DAF-12 is expressed widely in target tissues from embryo to adult, but is upregulated during midlarval stages. In the adult, expression persists in nervous system and somatic gonad, two tissues that regulate adult longevity. We propose that DAF-12 integrates hormonal signals in cellular targets to coordinate major life history traits.
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Cites
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
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The nuclear receptor superfamily: the second decade
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Crystallographic analysis of the interaction of the glucocorticoid receptor with DNA
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“…of mutations can be inferred, since nuclear receptors display a conserved architecture in DBDs and LBDs, including conserved positions for some DNA and ligand contact sites (Luisi et al. 1991; Schwabe et al. 1993; Bourguet et al. 1995; Renaud et al. 1995; Wagner et al. 1995; Wurtz et al. 1996).”
BackgroundRegulation of lifespan by sensory perception in Caenorhabditis elegans
Apfeld, J., & Kenyon, C. (1999) · Nature · doi:10.1038/45544 · Cited by 573
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Lin28: Primal Regulator of Growth and Metabolism in Stem Cells
Shyh-Chang, N., & Daley, G. Q. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.03.005 · Cited by 458
Sex and Death: What Is the Connection?
Partridge, L., Gems, D., & Withers, D. J. (2005) · Cell · doi:10.1016/j.cell.2005.01.026 · Cited by 402
Control of Developmental Timing by MicroRNAs and Their Targets
Pasquinelli, A. E., & Ruvkun, G. (2002) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.18.012502.105832 · Cited by 341
Goldstone, J. V., Hamdoun, A., Cole, B. J., Howard-Ashby, M., Nebert, D. W., Scally, M., Dean, M., Epel, D., Hahn, M. E., & Stegeman, J. J. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.08.066 · Cited by 280
Garrity, P. A., Goodman, M. B., Samuel, A. D., & Sengupta, P. (2010) · Genes & Development · doi:10.1101/gad.1953710 · Cited by 197
Metadata
- Authors
- Antebi, A., Yeh, W.-H., Tait, D., Hedgecock, E. M., & Riddle, D. L.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2000-06-15
- Volume
- 14
- Issue
- 12
- Pages
- 1512-1527
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2125969054
- Cited by
- 419
- References
- 5
- Type
- posted content
- Language
- en
- Open access
- diamond
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