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Sex and Death: What Is the Connection?

Partridge, Linda, Gems, David, Withers, Dominic J.·2005·Cell
DOI 10.1016/j.cell.2005.01.026
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Abstract

A cost of reproduction, where lifespan and fecundity are negatively correlated, is of widespread occurrence. Mutations in insulin/IGF signaling (IIS) pathways and dietary restriction (DR) can extend lifespan in model organisms but do not always reduce fecundity, suggesting that the link between lifespan and fecundity is not inevitable. Understanding the molecular basis of the cost of reproduction will be informed by elucidation of the mechanisms by which DR and IIS affect these two traits.

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Authors
Partridge, L., Gems, D., & Withers, D. J.
Venue
Cell
Publisher
Elsevier BV
Published
2005-02
Volume
120
Issue
4
Pages
461-472
ISSN
0092-8674
DOI
10.1016/j.cell.2005.01.026
Cited by
402
References
7
Language
en
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