The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Activin receptor patterning of foregut organogenesis
Open accessAbstract
Foregut development produces a characteristic sequence of gastrointestinal and respiratory organs, but the signaling pathways that ensure this developmental order remain largely unknown. Here, mutations of activin receptors ActRIIA and ActRIIB are shown to disrupt the development of posterior foregut-derived organs, including the stomach, pancreas, and spleen. Foregut expression of genes including Shh and Isl1 is shifted in mutant mice. The endocrine pancreas is particularly sensitive to the type and extent of receptor inactivation. ActRIIA+/−B+/−animals lack axial defects, but have hypoplastic pancreatic islets, hypoinsulinemia, and impaired glucose tolerance. Thus, activin receptor-mediated signaling regulates axial patterning, cell differentiation, and function of foregut-derived organs.
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“FGF2 and Activin, secreted by the notochord, lead to the expression of pancreatic markers by repressing expression of Shh in pancreatic endoderm [15-19].”
From A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE) (2007) · cites this paper as [17]
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Citations
Cites
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Self-citationDifferent phenotypes for mice deficient in either activins or activin receptor type II
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Westendorp, B. F., van Dop, W. A., & van den Brink, G. R. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809954-4.00004-9
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Anyfantis, G. (2015) · Research Explorer (The University of Manchester)
Regulatory Signaling in Pancreatic Organogenesis
Carrière, C., & Korc, M. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00310-7
Role of epidermal and fibroblast growth factors in pancreatic development
Pulkkinen, M. (2003) · Työväentutkimus Vuosikirja
Hedgehog Signaling in Gastrointestinal Morphogenesis and Morphostasis
van den Brink, G. R., Peppelenbosch, M. P., & Roberts, D. J. (2006) · Elsevier eBooks · doi:10.1016/b978-012088394-3/50012-x
Development of the Endocrine Pancreas
Hebrok, M., & German, M. S. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-5583-9.00031-9
Self-citationRegulation of pancreas development in Xenopus laevis
Pan, F. C. (2006) · doi:10.53846/goediss-3231
(2011) · Elsevier eBooks · doi:10.1016/b978-0-12-387819-9.00029-3
Acar, Ö. K., Nozhatzadeh, G. D., Kurtoglu, N., & Ayşan, E. (2024) · Springer eBooks · doi:10.1007/978-981-99-7119-0_20
Differentiation of pancreatic and hepatic cell types
Myatt, E. (2013) · The University of Bath Online Publications Store (The University of Bath)
In Vitro Development of Islets from Human Adult Pancreatic Tissues
Gao, R. (2008) · Työväentutkimus Vuosikirja
Metadata
- Authors
- Kim, S. K., Hebrok, M., Li, E., Oh, S. P., Schrewe, H., Harmon, E. B., Lee, J. S., & Melton, D. A.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2000-08-01
- Volume
- 14
- Issue
- 15
- Pages
- 1866-1871
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC316826
- OpenAlex
- W1768073869
- Cited by
- 212
- References
- 33
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 6 · 2019: 3 · 2018: 9 · 2017: 5 · 2016: 5 · 2015: 8 · 2014: 8 · 2013: 8 · 2012: 10
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- American Diabetes Association
- Donald E. and Delia B. Baxter Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- activin receptors, ActRIIA, ActRIIB, pancreatic islets, endocrine pancreas, hypoinsulinemia, glucose tolerance, stomach development, spleen development, Sonic hedgehog, Isl1, axial patterning, mouse mutants
- MeSH terms
- Animals, Cell Differentiation, Digestive System, Digestive System Physiological Phenomena, Glucose Tolerance Test, Hyperplasia, Insulin, Male, Mice, Mutant Strains, Nerve Tissue Proteins, Pancreas, Proteins, Spleen, Stomach, Transcription Factors, Trans-Activators, Receptors, Growth Factor, Homeodomain Proteins, Body Patterning, Activin Receptors, Type II, Mice, Hedgehog Proteins, LIM-Homeodomain Proteins
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