The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Activin receptor patterning of foregut organogenesis
Open accessAbstract
Foregut development produces a characteristic sequence of gastrointestinal and respiratory organs, but the signaling pathways that ensure this developmental order remain largely unknown. Here, mutations of activin receptors ActRIIA and ActRIIB are shown to disrupt the development of posterior foregut-derived organs, including the stomach, pancreas, and spleen. Foregut expression of genes including Shh and Isl1 is shifted in mutant mice. The endocrine pancreas is particularly sensitive to the type and extent of receptor inactivation. ActRIIA+/−B+/−animals lack axial defects, but have hypoplastic pancreatic islets, hypoinsulinemia, and impaired glucose tolerance. Thus, activin receptor-mediated signaling regulates axial patterning, cell differentiation, and function of foregut-derived organs.
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“FGF2 and Activin, secreted by the notochord, lead to the expression of pancreatic markers by repressing expression of Shh in pancreatic endoderm [15-19].”
From A systematic screen for genes expressed in definitive endoderm by Serial Analysis of Gene Expression (SAGE) (2007) · cites this paper as [17]
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Citations
Cites
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Self-citationDifferent phenotypes for mice deficient in either activins or activin receptor type II
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Generation of Functional Human Pancreatic β Cells In Vitro
Pagliuca, F. W., Millman, J. R., Gürtler, M., Segel, M., Van Dervort, A., Ryu, J. H., Peterson, Q. P., Greiner, D., & Melton, D. A. (2014) · Cell · doi:10.1016/j.cell.2014.09.040 · Cited by 2,025
“Studies on pancreatic development in model organisms (Gamer and Wright, 1995; Henry and Melton, 1998; Ninomiya et al., 1999; Apelqvist et al., 1999; Kim et al., 2000; Hebrok et al., 2000; Murtaugh et al., 2003) identified genes and signals important for the pancreatic lineage, and these have been…”
BackgroundSelf-citationVertebrate Endoderm Development and Organ Formation
Zorn, A. M., & Wells, J. M. (2009) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.042308.113344 · Cited by 812
“Shh in the stomach/duodenal domain is also regulated by Activin, and mouse embryos with Activin receptor mutations have a posterior shift in Shh expression (Kim et al. 2000).”
BackgroundBardeesy, N., Cheng, K.-H., Berger, J. H., Chu, G. C., Pahler, J., Olson, P., Hezel, A. F., Horner, J., Lauwers, G. Y., Hanahan, D., et al. (2006) · Genes & Development · doi:10.1101/gad.1478706 · Cited by 674
“Null mutations in the Activin signaling pathway are associated with gross pancreatic defects (Kim et al. 2000; Harmon et al. 2004).”
BackgroundThyroid Development and Its Disorders: Genetics and Molecular Mechanisms
Felice, M. D., & Lauro, R. D. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0028 · Cited by 655
TGF-β Tumor Suppression through a Lethal EMT
David, C. J., Huang, Y.-H., Chen, M., Su, J., Zou, Y., Bardeesy, N. M., Iacobuzio–Donahue, C. A., & Massagué, J. (2016) · Cell · doi:10.1016/j.cell.2016.01.009 · Cited by 597
Metadata
- Authors
- Kim, S. K., Hebrok, M., Li, E., Oh, S. P., Schrewe, H., Harmon, E. B., Lee, J. S., & Melton, D. A.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2000-08-01
- Volume
- 14
- Issue
- 15
- Pages
- 1866-1871
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC316826
- OpenAlex
- W1768073869
- Cited by
- 212
- References
- 33
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2020: 6 · 2019: 3 · 2018: 9 · 2017: 5 · 2016: 5 · 2015: 8 · 2014: 8 · 2013: 8 · 2012: 10
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- American Diabetes Association
- Donald E. and Delia B. Baxter Foundation
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- activin receptors, ActRIIA, ActRIIB, pancreatic islets, endocrine pancreas, hypoinsulinemia, glucose tolerance, stomach development, spleen development, Sonic hedgehog, Isl1, axial patterning, mouse mutants
- MeSH terms
- Animals, Cell Differentiation, Digestive System, Digestive System Physiological Phenomena, Glucose Tolerance Test, Hyperplasia, Insulin, Male, Mice, Mutant Strains, Nerve Tissue Proteins, Pancreas, Proteins, Spleen, Stomach, Transcription Factors, Trans-Activators, Receptors, Growth Factor, Homeodomain Proteins, Body Patterning, Activin Receptors, Type II, Mice, Hedgehog Proteins, LIM-Homeodomain Proteins
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