The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination
Open accessAbstract
Eukaryotes possess mechanisms to limit crossing over during homologous recombination, thus avoiding possible chromosomal rearrangements. We show here that budding yeast Mph1, an ortholog of human FancM helicase, utilizes its helicase activity to suppress spontaneous unequal sister chromatid exchanges and DNA double-strand break-induced chromosome crossovers. Since the efficiency and kinetics of break repair are unaffected, Mph1 appears to channel repair intermediates into a noncrossover pathway. Importantly, Mph1 works independently of two other helicases—Srs2 and Sgs1—that also attenuate crossing over. By chromatin immunoprecipitation, we find targeting of Mph1 to double-strand breaks in cells. Purified Mph1 binds D-loop structures and is particularly adept at unwinding these structures. Importantly, Mph1, but not a helicase-defective variant, dissociates Rad51-made D-loops. Overall, the results from our analyses suggest a new role of Mph1 in promoting the noncrossover repair of DNA double-strand breaks.
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Cites
Biallelic Inactivation of BRCA2 in Fanconi Anemia
Howlett, N. G., Taniguchi, T., Olson, S., Cox, B., Waisfisz, Q., de Die-Smulders, C., Persky, N., Grompe, M., Joenje, H., Pals, G., et al. (2002) · Science · doi:10.1126/science.1073834 · Cited by 1,149
Litman, R., Peng, M., Jin, Z., Zhang, F., Zhang, J., Powell, S., Andreassen, P. R., & Cantor, S. B. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.08.004 · Cited by 396
The Werner syndrome helicase/exonuclease (WRN) disrupts and degrades D-loops in vitro
Orren, D. K., Theodore, S., & Machwe, A. (2002) · Biochemistry · doi:10.1021/bi0266986 · Cited by 112
Cited by
Mechanisms of change in gene copy number
Hastings, P. J., Lupski, J. R., Rosenberg, S. M., & Ira, G. (2009) · Nature Reviews Genetics · doi:10.1038/nrg2593 · Cited by 1,316
Self-citationRegulation of Homologous Recombination in Eukaryotes
Heyer, W.-D., Ehmsen, K. T., & Liu, J. (2010) · Annual Review of Genetics · doi:10.1146/annurev-genet-051710-150955 · Cited by 1,066
Homologous recombination and the repair of DNA double-strand breaks
Wright, W. D., Shah, S. S., & Heyer, W.-D. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.tm118.000372 · Cited by 713
Mating-Type Genes and MAT Switching in Saccharomyces cerevisiae
Haber, J. E. (2012) · Genetics · doi:10.1534/genetics.111.134577 · Cited by 425
Self-citationRanjha, L., Howard, S. M., & Cejka, P. (2018) · Chromosoma · doi:10.1007/s00412-017-0658-1 · Cited by 325
Metadata
- Authors
- Prakash, R., Satory, D., Dray, E., Papusha, A., Scheller, J., Kramer, W., Krejci, L., Klein, H., Haber, J. E., Sung, P., & Ira, G.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-01-01
- Volume
- 23
- Issue
- 1
- Pages
- 67-79
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2009167909
- Cited by
- 255
- References
- 3
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Prakash, R., Satory, D., Dray, E., Papusha, A., Scheller, J., Kramer, W., Krejci, L., Klein, H., Haber, J. E., Sung, P., & Ira, G. (2009). Yeast Mph1 helicase dissociates Rad51-made D-loops: implications for crossover control in mitotic recombination. Genes & Development. https://doi.org/10.1101/gad.1737809
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