The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Wnt signaling pathways meet Rho GTPases
Open accessAbstract
Wnt ligands and their receptors orchestrate many essential cellular and physiological processes. During development they control differentiation, proliferation, migration, and patterning, while in the adult, they regulate tissue homeostasis, primarily through their effects on stem cell proliferation and differentiation. Underpinning these diverse biological activities is a complex set of intracellular signaling pathways that are still poorly understood. Rho GTPases have emerged as key mediators of Wnt signals, most notably in the noncanonical pathways that involve polarized cell shape changes and migrations, but also more recently in the canonical pathway leading to β-catenin-dependent transcription. It appears that Rho GTPases integrate Wnt-induced signals spatially and temporally to promote morphological and transcriptional changes affecting cell behavior.
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Cites
RHO GTPASES: Biochemistry and Biology
Jaffe, A. B., & Hall, A. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.020604.150721 · Cited by 3,009
Self-citationCdc42 regulates GSK-3β and adenomatous polyposis coli to control cell polarity
Etienne-Manneville, S., & Hall, A. (2003) · Nature · doi:10.1038/nature01423 · Cited by 835
Self-citationBoutros, M., Paricio, N., Strutt, D. I., & Mlodzik, M. (1998) · Cell · doi:10.1016/s0092-8674(00)81226-x · Cited by 801
Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation
Habas, R., Dawid, I. B., & He, X. (2003) · Genes & Development · doi:10.1101/gad.1022203 · Cited by 603
Hippocampal Neuronal Polarity Specified by Spatially Localized mPar3/mPar6 and PI 3-Kinase Activity
Shi, S.-H., Jan, L. Y., & Jan, Y.-N. (2003) · Cell · doi:10.1016/s0092-8674(02)01249-7 · Cited by 600
Frizzled/PCP signalling: a conserved mechanism regulating cell polarity and directed motility
Seifert, J. R. K., & Mlodzik, M. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2042 · Cited by 513
Wnt signaling through Dishevelled, Rac and JNK regulates dendritic development
Rosso, S. B., Sussman, D., Wynshaw-Boris, A., & Salinas, P. C. (2005) · Nature Neuroscience · doi:10.1038/nn1374 · Cited by 485 · cited 1×
“A canonical Wnt pathway controls endoderm induction, through the Frizzled receptor MOM-5, but a noncanonical pathway, also dependent on MOM-5, is required for spindle reorientation (Schlesinger et al. 1999).”
BackgroundThe sequential activity of the GTPases Rap1B and Cdc42 determines neuronal polarity.
Schwamborn, J. C., & Püschel, A. W. (2004) · Nature Neuroscience · doi:10.1038/nn1295 · Cited by 385
Marlow, F., Topczewski, J., Sepich, D., & Solnica-Krezel, L. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00864-3 · Cited by 337
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Florian, M. C., Nattamai, K. J., Dörr, K., Marka, G., Überle, B., Vas, V., Eckl, C., Andrä, I., Schiemann, M., Oostendorp, R. A. J., et al. (2013) · Nature · doi:10.1038/nature12631 · Cited by 303
Wnt4 from the Niche Controls the Mechano-Properties and Quiescent State of Muscle Stem Cells
Eliazer, S., Muncie, J. M., Christensen, J., Sun, X., D’Urso, R. S., Weaver, V. M., & Brack, A. S. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.08.007 · Cited by 171
“Rho GTPase is a well-characterized downstream component of non-canonical Wnt signaling pathway, first identified during gastrulation, to promote polarized cell shape changes and migration (Habas et al., 2003; Schlessinger et al., 2009).”
BackgroundProtein kinase N3 promotes bone resorption by osteoclasts in response to Wnt5a-Ror2 signaling
Uehara, S., Udagawa, N., Mukai, H., Ishihara, A., Maeda, K., Yamashita, T., Murakami, K., Nishita, M., Nakamura, T., Kato, S., et al. (2017) · Science Signaling · doi:10.1126/scisignal.aan0023 · Cited by 83
MiR-139-5p: promising biomarker for cancer
Zhang, H.-D., Jiang, L.-H., Sun, D.-W., Li, J., & Tang, J.-H. (2015) · Tumor Biology · doi:10.1007/s13277-015-3199-3 · Cited by 69
Metadata
- Authors
- Schlessinger, K., Hall, A., & Tolwinski, N.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2009-02-01
- Volume
- 23
- Issue
- 3
- Pages
- 265-277
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2001670860
- Cited by
- 366
- References
- 14
- Type
- posted content
- Language
- en
- Open access
- diamond
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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