The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
The Hippo–YAP pathway in organ size control and tumorigenesis: an updated version
Open accessAbstract
The Hippo signaling pathway is gaining recognition as an important player in both organ size control and tumorigenesis, which are physiological and pathological processes that share common cellular signaling mechanisms. Upon activation by stimuli such as high cell density in cell culture, the Hippo pathway kinase cascade phosphorylates and inhibits the Yes-associated protein (YAP)/TAZ transcription coactivators representing the major signaling output of the pathway. Altered gene expression resulting from YAP/TAZ inhibition affects cell number by repressing cell proliferation and promoting apoptosis, thereby limiting organ size. Recent studies have provided new insights into the Hippo signaling pathway, elucidating novel phosphorylation-dependent and independent mechanisms of YAP/Yki inhibition by the Hippo pathway, new Hippo pathway components, novel YAP target transcription factors and target genes, and the three-dimensional structure of the YAP–TEAD complex, and providing further evidence for the involvement of YAP and the Hippo pathway in tumorigenesis.
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Self-citationA coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF β-TRCP
Zhao, B., Li, L., Tumaneng, K., Wang, C.-Y., & Guan, K.-L. (2010) · Genes & Development · doi:10.1101/gad.1843810 · Cited by 1,418
Self-citationYAP1 increases organ size and expands undifferentiated progenitor cells
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Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways
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“2009), and their Drosophila homolog Sd in mediating the functions of Yki (Goulev et al. 2008; Wu et al. 2008; L Zhang et al. 2008).”
BackgroundInfluentialThe Ste20-like kinase Mst2 activates the human large tumor suppressor kinase Lats1
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Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development
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Cited by
Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling
Yu, F.-X., Zhao, B., Panupinthu, N., Jewell, J. L., Lian, I., Wang, L. H., Zhao, J., Yuan, H., Tumaneng, K., Li, H., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.037 · Cited by 1,628
Self-citationLiu-Chittenden, Y., Huang, B., Shim, J. S., Chen, Q., Lee, S.-J., Anders, R. A., Liu, J. O., & Pan, D. (2012) · Genes & Development · doi:10.1101/gad.192856.112 · Cited by 1,452
Force triggers YAP nuclear entry by regulating transport across nuclear pores
Elosegui-Artola, A., Andreu, I., Beedle, A. E. M., Lezamiz, A., Uroz, M., Kosmalska, A. J., Oria, R., Kechagia, J. Z., Rico-Lastres, P., Le Roux, A.-L., et al. (2017) · Cell · doi:10.1016/j.cell.2017.10.008 · Cited by 1,491
The Hippo pathway: regulators and regulations.
Yu, F.-X., & Guan, K.-L. (2013) · Genes & Development · doi:10.1101/gad.210773.112 · Cited by 1,231
Self-citationTransduction of mechanical and cytoskeletal cues by YAP and TAZ
Halder, G., Dupont, S., & Piccolo, S. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3416 · Cited by 985
Metadata
- Authors
- Zhao, B., Li, L., Lei, Q., & Guan, K.-L.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2010-05-01
- Volume
- 24
- Issue
- 9
- Pages
- 862-874
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2124059822
- Cited by
- 1,144
- References
- 10
- Type
- posted content
- Language
- en
- Open access
- diamond
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