The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Induced pluripotency: history, mechanisms, and applications
Open accessAbstract
The generation of induced pluripotent stem cells (iPSCs) from somatic cells demonstrated that adult mammalian cells can be reprogrammed to a pluripotent state by the enforced expression of a few embryonic transcription factors. This discovery has raised fundamental questions about the mechanisms by which transcription factors influence the epigenetic conformation and differentiation potential of cells during reprogramming and normal development. In addition, iPSC technology has provided researchers with a unique tool to derive disease-specific stem cells for the study and possible treatment of degenerative disorders with autologous cells. In this review, we summarize the progress that has been made in the iPSC field over the last 4 years, with an emphasis on understanding the mechanisms of cellular reprogramming and its potential applications in cell therapy.
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Cites
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Cited by
Pluripotent stem cells induced from mouse somatic cells by small-molecule compounds.
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A Molecular Roadmap of Reprogramming Somatic Cells into iPS Cells
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Self-citationEmerging trends and new developments in regenerative medicine: a scientometric update (2000 – 2014)
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Understanding multicellular function and disease with human tissue-specific networks
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Metadata
- Authors
- Stadtfeld, M., & Hochedlinger, K.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2010-10-15
- Volume
- 24
- Issue
- 20
- Pages
- 2239-2263
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2135086442
- Cited by
- 829
- References
- 29
- Type
- posted content
- Language
- en
- Open access
- diamond
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