The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197

ASSEMBLY OF ASPARAGINE-LINKED OLIGOSACCHARIDES

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The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

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AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

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Defining the role of mTOR in cancer

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Beyond aerobic glycolysis: transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

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ATP-citrate lyase links cellular metabolism to histone acetylation

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c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism

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Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction

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The LKB1-AMPK pathway: metabolism and growth control in tumour suppression

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An integrative theory for cancer (Review)

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Glucose metabolism and tumour microenvironment in pancreatic cancer: A key link in cancer progression

Dong, S., Li, W., Li, X., Wang, Z., Zhou, C., Shi, H., He, R., Chen, C., & Zhou, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1038650 · Cited by 33

Glutamine, Glucose and other Fuels for Cancer

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Regulatory role of hexosamine biosynthetic pathway on hepatic cancer stem cell marker CD133 under low glucose conditions

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Global alteration of T-lymphocyte metabolism by PD-L1 checkpoint involves a block of de novo nucleoside phosphate synthesis

Palaskas, N. J., Garcia, J. D., Shirazi, R., Shin, D. S., Puig-Saus, C., Braas, D., Ribas, A., & Graeber, T. G. (2019) · Cell Discovery · doi:10.1038/s41421-019-0130-x · Cited by 31

Growing and dividing: how O-GlcNAcylation leads the way

Saunders, H. I., Dias, W. B., & Slawson, C. M. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105330 · Cited by 30

Targeting Protein O-GlcNAcylation, a Link between Type 2 Diabetes Mellitus and Inflammatory Disease

Bolanle, I. O., & Palmer, T. M. (2022) · Cells · doi:10.3390/cells11040705 · Cited by 30

Rubella Viruses Shift Cellular Bioenergetics to a More Oxidative and Glycolytic Phenotype with a Strain-Specific Requirement for Glutamine

Bilz, N. C., Jahn, K., Lorenz, M., Lüdtke, A., Hübschen, J. M., Geyer, H., Mankertz, A., Hübner, D., Liebert, U. G., & Claus, C. (2018) · Journal of Virology · doi:10.1128/jvi.00934-18 · Cited by 30

Regulation of protein O-GlcNAcylation by circadian, metabolic, and cellular signals

Liu, X., Cai, Y. D., & Chiu, J. C. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105616 · Cited by 29

From gametogenesis and stem cells to cancer: common metabolic themes

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Biophysical changes reduce energetic demand in growth factor–deprived lymphocytes

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Mast cells inhibit colorectal cancer development by inducing ER stress through secreting Cystatin C

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Enzymatic passaging of human embryonic stem cells alters central carbon metabolism and glycan abundance

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Selection of Metastatic Breast Cancer Cells Based on Adaptability of Their Metabolic State

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A metabolic perturbation by U0126 identifies a role for glutamine in resveratrol-induced cell death

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Does Tumor FDG-PET Avidity Represent Enhanced Glycolytic Metabolism in Non-Small Cell Lung Cancer?

Kernstine, K. H., Faubert, B., Do, Q. N., Rogers, T. J., Hensley, C. T., Cai, L., Torrealba, J. R., Oliver, D., Wachsmann, J., Lenkinski, R. E., et al. (2019) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2019.10.061 · Cited by 25

Expression and Bioinformatics-Based Functional Analysis of UAP1 in Lung Adenocarcinoma

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High glutamine suppresses osteogenesis through mTORC1-mediated inhibition of the mTORC2/AKT-473/RUNX2 axis

Gayatri, M. B., Gajula, N. N., Chava, S., & Reddy, A. B. M. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-01077-3 · Cited by 27

Metabolic cross-talk within the bone marrow milieu: focus on multiple myeloma

Oudaert, I., der Vreken, A. V., Maes, A., Bruyne, E. D., Veirman, K. D., Vanderkerken, K., & Menu, E. (2022) · Experimental Hematology and Oncology · doi:10.1186/s40164-022-00303-z · Cited by 27

Glucose and glutamine metabolism control by APC and SCF during the G1-to-S phase transition of the cell cycle

Estévez-García, I. O., Cordoba-Gonzalez, V., Lara‐Padilla, E., Fuentes-Toledo, A., Falfán‐Valencia, R., Campos‐Rodríguez, R., & Abarca‐Rojano, E. (2014) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-014-0328-1 · Cited by 25

Monocarboxylate Transporter-1 (MCT1)-Mediated Lactate Uptake Protects Pancreatic Adenocarcinoma Cells from Oxidative Stress during Glutamine Scarcity Thereby Promoting Resistance against Inhibitors of Glutamine Metabolism

Ammar, N., Hildebrandt, M., Geismann, C., Röder, C., Gemoll, T., Sebens, S., Trauzold, A., & Schäfer, H. (2023) · Antioxidants · doi:10.3390/antiox12101818 · Cited by 27

Intersections between mitochondrial sirtuin signaling and tumor cell metabolism

Herrera, K. N. G., Lee, J. J., & Haigis, M. C. (2015) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.3109/10409238.2015.1031879 · Cited by 25

MYC and AMPK–Save Energy or Die!

Haikala, H. M., Anttila, J. M., & Klefström, J. T. (2017) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2017.00038 · Cited by 25

Pharmacologic approaches to amino acid depletion for cancer therapy

Wilder, C. S., Chen, Z., & DiGiovanni, J. (2021) · Molecular Carcinogenesis · doi:10.1002/mc.23349 · Cited by 23

Connections between metabolism and epigenetic modifications in cancer

Wang, G., & Han, J. J. (2021) · Medical Review · doi:10.1515/mr-2021-0015 · Cited by 27

Glutamine-dependent signaling controls pluripotent stem cell fate

Lu, V., Roy, I. J., Torres, A., Joly, J. H., Ahsan, F. M., Graham, N. A., & Teitell, M. A. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.02.003 · Cited by 23

Inhibition of O-GlcNAcylation Decreases the Cytotoxic Function of Natural Killer Cells

Feinberg, D. M., Ramakrishnan, P., Wong, D. P., Asthana, A., & Parameswaran, R. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.841299 · Cited by 23

Amino acid metabolism regulated by lncRNAs: the propellant behind cancer metabolic reprogramming

Hu, Q., Li, Y., Li, D., Yuan, Y., Wang, K., Lü, Y., Cheng, Z., & Han, T. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01116-1 · Cited by 23

Overexpression of Fatty Acid Synthase Upregulates Glutamine–Fructose-6-Phosphate Transaminase 1 and O-Linked N-Acetylglucosamine Transferase to Increase O-GlcNAc Protein Glycosylation and Promote Colorectal Cancer Growth

Drury, J., Geisen, M. E., Tessmann, J. W., Rychahou, P. G., Kelson, C. O., He, D., Wang, C., Evers, B. M., & Zaytseva, Y. Y. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25094883 · Cited by 25

Non-Invasive Glutamine PET Reflects Pharmacological Inhibition of BRAFV600E In Vivo

Schulte, M. I., Hight, M. R., Ayers, G. D., Liu, Q., Shyr, Y., Washington, M. K., & Manning, H. C. (2016) · Molecular Imaging and Biology · doi:10.1007/s11307-016-1008-z · Cited by 23

Human metapneumovirus infection of airway epithelial cells is associated with changes in core metabolic pathways

Zhao, Y., Chahar, H. S., Komaravelli, N., Dossumbekova, A., & Casola, A. (2019) · Virology · doi:10.1016/j.virol.2019.03.011 · Cited by 23

Targeting the metabolism of cancer stem cells by energy disruptor molecules

Dadgar, T., Ebrahimi, N., Gholipour, A. R., Akbari, M., Khani, L., Ahmadi, A., & Hamblin, M. R. (2021) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2021.103545 · Cited by 22

Specificity Protein 1-Mediated Promotion of CXCL12 Advances Endothelial Cell Metabolism and Proliferation in Pulmonary Hypertension

DeVallance, E., Dustin, C. M., de Jesus, D. S., Ghouleh, I. A., Sembrat, J., Cifuentes-Pagano, E., & Pagano, P. J. (2022) · Antioxidants · doi:10.3390/antiox12010071 · Cited by 22

Formyl-Peptide Receptor 2 Signaling Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming of Lung Cancer Cells

Cimmino, T. P., Pagano, E., Stornaiuolo, M., Esposito, G., Ammendola, R., & Cattaneo, F. (2022) · Antioxidants · doi:10.3390/antiox11091692 · Cited by 23

SLC3A2 N-glycosylation and Golgi remodeling regulate SLC7A amino acid exchangers and stress mitigation

Zhang, C., Shafaq‐Zadah, M., Pawling, J., Hesketh, G. G., Dransart, E., Pacholczyk, K., Longo, J., Gingras, A., Penn, L. Z., Johannes, L., et al. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105416 · Cited by 22

Protective effect of Cardiospermum halicacabum leaf extract on glycoprotein components on STZ–induced hyperglycemic rats

Veeramani, C., Al‐Numair, K. S., Alsaif, M. A., Govindasamy, C., Al‐Numair, N. S., & Pugalendi, K. V. (2012) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/s1995-7645(12)60178-3 · Cited by 20

Regulation of cancer metabolism by O-GlcNAcylation

Li, Z., & Yi, W. (2013) · Glycoconjugate Journal · doi:10.1007/s10719-013-9515-5 · Cited by 21

Dysregulation of hexosamine biosynthetic pathway wiring metabolic signaling circuits in cancer

Itano, N., & Iwamoto, S. (2022) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2022.130250 · Cited by 23

High Levels of Prebiotic Resistant Starch in Diet Modulate Gene Expression and Metabolomic Profile in Pancreatic Cancer Xenograft Mice

Panebianco, C., Villani, A., & Pazienza, V. (2019) · Nutrients · doi:10.3390/nu11040709 · Cited by 19

Genetic loss of Nrf1 and Nrf2 leads to distinct metabolism reprogramming of HepG2 cells by opposing regulation of the PI3K-AKT-mTOR signalling pathway

Deng, R., Zhu, Y., Liu, K., Zhang, Q., Hu, S., Wang, M., & Zhang, Y. (2024) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2024.107212 · Cited by 18

Cooperative nutrient accumulation sustains growth of mammalian cells

Son, S., Stevens, M. M., Chao, H. X., Thoreen, C. C., Hosios, A. M., Schweitzer, L. D., Weng, Y., Wood, K. C., Sabatini, D. M., Heiden, M. G. V., et al. (2015) · Scientific Reports · doi:10.1038/srep17401 · Cited by 18

Glutamine is critical for the maintenance of type 1 conventional dendritic cells in normal tissue and the tumor microenvironment

Lobel, G. P., Han, N., Arocho, W. A. M., Silber, M., Shoush, J., Noji, M., To, T. K. J., Zhai, L., Lesner, N. P., Simon, M. C., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2412157121 · Cited by 19

The hexosamine biosynthetic pathway rescues lysosomal dysfunction in Parkinson’s disease patient iPSC derived midbrain neurons

Wani, W. Y., Zunke, F., Belur, N. R., & Mazzulli, J. R. (2024) · Nature Communications · doi:10.1038/s41467-024-49256-3 · Cited by 17

ER stress and hexosamine pathway during tumourigenesis: A pas de deux?

Vasseur, S., & Manié, S. N. (2015) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2015.04.001 · Cited by 18

Synergic chemoprevention with dietary carbohydrate restriction and supplementation of AMPK-activating phytochemicals

Lee, J. D., Choi, M., Ro, S. W., Yang, W. I., Cho, A. E.-H., Ju, H.-L., Baek, S., Chung, S. I., Kang, W. J., Yun, M., et al. (2015) · European Journal of Cancer Prevention · doi:10.1097/cej.0000000000000141 · Cited by 18

Discovery of a novel OGT inhibitor through high-throughput screening based on Homogeneous Time-Resolved Fluorescence (HTRF)

Wu, X., Wang, M., Cao, Y., Xu, Y., Yang, Z., Ding, Y., Lu, J., Zheng, J., Luo, C., Zhao, K., et al. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.106726 · Cited by 16

Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells

Møller, S. H., Mellergaard, M., Madsen, M. G., Bermejo, A. V., Jepsen, S. D., Hansen, M. H., Høgh, R. I., Aldana, B. I., Desler, C., Rasmussen, L. J., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01968 · Cited by 16

Slt2 Is Required to Activate ER-Stress-Protective Mechanisms through TORC1 Inhibition and Hexosamine Pathway Activation

Sánchez‐Adriá, I. E., Sanmartín, G., Prieto, J. A., Estruch, F., & Rández‐Gil, F. (2022) · Journal of Fungi · doi:10.3390/jof8020092 · Cited by 15

Correlation between amino acid metabolism and self-renewal of cancer stem cells: Perspectives in cancer therapy

Zhang, Q., & Li, W. (2022) · World Journal of Stem Cells · doi:10.4252/wjsc.v14.i4.267 · Cited by 16

2-Deoxy-d-Glucose-Induced Metabolic Alteration in Human Oral Squamous SCC15 Cells: Involvement of N-Glycosylation of Axl and Met

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Disruption of redox homeostasis for combinatorial drug efficacy in K-Ras tumors as revealed by metabolic connectivity profiling

Gaglio, D., Bonanomi, M., Valtorta, S., Bharat, R., Ripamonti, M., Conte, F., Fiscon, G., Righi, N., Napodano, E., Papa, F., et al. (2020) · Cancer & Metabolism · doi:10.1186/s40170-020-00227-4 · Cited by 15

O-GlcNAcylation in Renal (Patho)Physiology

Silva-Aguiar, R. P., Peruchetti, D. B., Pinheiro, A. A. S., Caruso‐Neves, C., & Dias, W. B. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911260 · Cited by 15

The clinical and mechanistic intersection of primary atopic disorders and inborn errors of growth and metabolism

Lyons, J. J., & Milner, J. D. (2018) · Immunological Reviews · doi:10.1111/imr.12727 · Cited by 16

Exploring the metabolic signaling network of GFPT in cancer

Sampson, C., Li, P., Wang, Y., Liu, J., Lv, J., Xia, T., Piao, H., & Ma, Y. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02687-3 · Cited by 16

The Contribution of Phospholipase A2 and Metalloproteinases to the Synergistic Action of Viper Venom on the Bioenergetic Profile of Vero Cells

Ayvazyan, N. M., Ghukasyan, G., Ghulikyan, L. A., Kirakosyan, G. R., Sevoyan, G., Voskanyan, A., & Karabekian, Z. I. (2022) · Toxins · doi:10.3390/toxins14110724 · Cited by 14

Concomitant reduction of lactate and ammonia accumulation in fed‐batch cultures: Impact on glycoprotein production and quality

Karengera, E., Robotham, A. C., Kelly, J., Durocher, Y., Crescenzo, G. D., & Henry, O. (2018) · Biotechnology Progress · doi:10.1002/btpr.2607 · Cited by 14

Dietary supplementary glutamine and L-carnitine enhanced the anti-cold stress of Arbor Acres broilers

Liu, Y., Yang, Y., Yao, R., Hu, Y., Liu, P., Lian, S., Lv, H., Xu, B., & Li, S. (2021) · Archives animal breeding/Archiv für Tierzucht · doi:10.5194/aab-64-231-2021 · Cited by 14

Dietary glucosamine overcomes the defects in αβ-T cell ontogeny caused by the loss of de novo hexosamine biosynthesis

Werlen, G., Li, M., Tottone, L., da Silva-Diz, V., Su, X., Herranz, D., & Jacinto, E. (2022) · Nature Communications · doi:10.1038/s41467-022-35014-w · Cited by 14

Metabolic Signature Genes Associated with Susceptibility to Pyruvate Kinase, Muscle Type 2 Gene Ablation in Cancer Cells

Jung, Y., Jang, Y. J., Kang, M. H., Park, Y. S., Oh, S. J., Lee, D. C., Zhi, X., Yoo, H., Park, K. C., & Yeom, Y. I. (2013) · Molecules and Cells · doi:10.1007/s10059-013-2319-4 · Cited by 15

Mechanism and Physiological Significance of Growth Factor-Related Autophagy

Li, T. Y., Lin, S., & Lin, S. (2013) · Physiology · doi:10.1152/physiol.00023.2013 · Cited by 16

Noninferiority of99mTc-Ethylenedicysteine-Glucosamine as an Alternative Analogue to18F-Fluorodeoxyglucose in the Detection and Staging of Non-Small Cell Lung Cancer

Dai, D., Rollo, F. D., Bryant, J. L., & Kim, E. E. (2018) · Contrast Media & Molecular Imaging · doi:10.1155/2018/8969714 · Cited by 14

Anti‐Tumor Strategies Targeting Nutritional Deprivation: Challenges and Opportunities

Shi, J., Han, W., Wang, J., & Kong, X. (2025) · Advanced Materials · doi:10.1002/adma.202415550 · Cited by 14

HLA class II alleles and risk for peripheral neuropathy in type 2 diabetes patients

Solgi, G., Marzban, A., Kiani, J., Hajilooi, M., Rezaei, H., & Kahramfar, Z. (2016) · Neural Regeneration Research · doi:10.4103/1673-5374.194756 · Cited by 13

N-acetylglucosamine: more than a silent partner in insulin resistance

Hesketh, G. G., & Dennis, J. W. (2017) · Glycobiology · doi:10.1093/glycob/cwx035 · Cited by 13

Understanding lymphocyte metabolism for use in cancer immunotherapy

MacPherson, S., Kilgour, M. K., & Lum, J. J. (2018) · FEBS Journal · doi:10.1111/febs.14454 · Cited by 14

Life, death, and the metabolically controlled protein acetylome

Johnson, E. S., & Kornbluth, S. A. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.10.002 · Cited by 12

Study of Global Transcriptional Changes of N-GlcNAc2 Proteins-Producing T24 Bladder Carcinoma Cells under Glucose Deprivation

Isono, T., Chano, T., Okabe, H., & Suzaki, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060397 · Cited by 13

The Role of Pi, Glutamine and the Essential Amino Acids in Modulating the Metabolism in Diabetes and Cancer

Vadlakonda, L., Indracanti, M., Kalangi, S. K., Gayatri, B. M., Gajula, N. N., & Reddy, A. B. M. (2020) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-020-00566-5 · Cited by 11

Multitranscript analysis reveals an effect of 2-deoxy-d-glucose on gene expression linked to unfolded protein response and integrated stress response in primary human monocytes and monocyte-derived macrophages

Tamayo-Molina, Y. S., Velilla, P. A., Hernández-Sarmiento, L. J., & Inchima, S. U. (2023) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2023.130397 · Cited by 13

Experimental and computational investigation of the kinetic evolution of the glutaminolysis pathway and its interplay with the glycolysis pathway

Mirveis, Z., Patil, N., & Byrne, H. J. (2024) · FEBS Open Bio · doi:10.1002/2211-5463.13841 · Cited by 9

Increasing cisplatin exposure promotes small-cell lung cancer transformation after a shift from glucose metabolism to fatty acid metabolism

Zhao, Q., Liu, W.-J., Wang, J., Li, H., Lv, J.-L., Wang, Y., & Wang, C. (2025) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-025-06164-3 · Cited by 11

Metabolic decisions in development and disease—a Keystone Symposia report

Cable, J., Pourquié, O., Wellen, K. E., Finley, L. W. S., Aulehla, A., Gould, A. P., Teleman, A. A., Tu, W. B., Garrett, W. S., Miguel‐Aliaga, I., et al. (2021) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.14678 · Cited by 13

Association Between Human Metabolomics and Rheumatoid Arthritis: A Systematic Review and Meta-analysis

Song, L., Wang, J., Zhang, Y., Yan, X., He, J., Nie, J., Zhang, F., Han, R., Yin, H., Li, J., et al. (2023) · Archives of Medical Research · doi:10.1016/j.arcmed.2023.102907 · Cited by 13

Canceromics Studies Unravel Tumor’s Glutamine Addiction After Metabolic Reprogramming

Márquez, J., Matés, J. M., Alonso, F. J., Martín‐Rufián, M., Lobo, C., & Campos-Sandoval, J. A. (2015) · Springer eBooks · doi:10.1007/978-3-7091-1824-5_12 · Cited by 11

How the immune system spots tumors

Okabe, Y., & Medzhitov, R. M. (2014) · eLife · doi:10.7554/elife.04476 · Cited by 11

Molecular signature of renal cell carcinoma by means of a multiplatform metabolomics analysis

Kordalewska, M., Wawrzyniak, R., Jacyna, J., Godzień, J., López‐Gonzálvez, Á., Raczak‐Gutknecht, J., Markuszewski, M., Gutknecht, P. G., Matuszewski, M., Siebert, J., et al. (2022) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2022.101318 · Cited by 10

Studying N-Linked Glycosylation of Receptor Tyrosine Kinases

Itkonen, H. M., & Mills, I. G. (2014) · Methods in molecular biology · doi:10.1007/978-1-4939-1789-1_10 · Cited by 9

Nutrient-sensitive protein O-GlcNAcylation shapes daily biological rhythms

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Targeting PGM3 abolishes SREBP-1 activation-hexosamine synthesis feedback regulation to effectively suppress brain tumor growth

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