The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
The hexosamine biosynthetic pathway couples growth factor-induced glutamine uptake to glucose metabolism
Open accessAbstract
Glucose and glutamine serve as the two primary carbon sources in proliferating cells, and uptake of both nutrients is directed by growth factor signaling. Although either glucose or glutamine can potentially support mitochondrial tricarboxylic acid (TCA) cycle integrity and ATP production, we found that glucose deprivation led to a marked reduction in glutamine uptake and progressive cellular atrophy in multiple mammalian cell types. Despite the continuous presence of growth factor and an abundant supply of extracellular glutamine, interleukin-3 (IL-3)-dependent cells were unable to maintain TCA cycle metabolite pools or receptor-dependent signal transduction when deprived of glucose. This was due at least in part to down-regulation of IL-3 receptor α (IL-3Rα) surface expression in the absence of glucose. Treatment of glucose-starved cells with N-acetylglucosamine (GlcNAc) to maintain hexosamine biosynthesis restored mitochondrial metabolism and cell growth by promoting IL-3-dependent glutamine uptake and metabolism. Thus, glucose metabolism through the hexosamine biosynthetic pathway is required to sustain sufficient growth factor signaling and glutamine uptake to support cell growth and survival.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“It would also fit with the importance of glucose carbon to be metabolized through other branches of glycolytic metabolism, including serine synthesis (as discussed above) and the hexosamine pathway (Wellen et al., 2010).”
From Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate (2012) · cites this paper as Wellen et al., 2010
In the citing paper
“But they also collaborate in another biochemical pathway to produce hexosamines, which modify nutrient transporters and growth factor receptors, enabling their expression on the cell membrane (Figure 2).”
From Cellular Metabolism and Disease: What Do Metabolic Outliers Teach Us? (2012) · cites this paper as Wellen et al., 2010
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197
Self-citationASSEMBLY OF ASPARAGINE-LINKED OLIGOSACCHARIDES
Kornfeld, R., & Kornfeld, S. A. (1985) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.54.070185.003215 · Cited by 4,863
The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088
Self-citationAMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint
Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk, B. E., & Shaw, R. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.003 · Cited by 3,849
Defining the role of mTOR in cancer
Guertin, D. A., & Sabatini, D. M. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.05.008 · Cited by 2,833
DeBerardinis, R. J., Mancuso, A., Daikhin, E., Nissim, I., Yudkoff, M., Wehrli, S., & Thompson, C. B. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709747104 · Cited by 2,622
Self-citationATP-citrate lyase links cellular metabolism to histone acetylation
Wellen, K. E., Hatzivassiliou, G., Sachdeva, U. M., Bui, T. V., Cross, J. R., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1164097 · Cited by 2,298
Self-citationGao, P., Tchernyshyov, I., Chang, T.-C., Lee, Y.-S., Kita, K., Ochi, T., Zeller, K. I., De Marzo, A. M., Van Eyk, J. E., Mendell, J. T., et al. (2009) · Nature · doi:10.1038/nature07823 · Cited by 2,124
Wise, D. R., DeBerardinis, R. J., Mancuso, A., Sayed, N., Zhang, X.-Y., Pfeiffer, H. K., Nissim, I., Daikhin, E., Yudkoff, M., McMahon, S. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0810199105 · Cited by 2,001
Self-citationThe LKB1-AMPK pathway: metabolism and growth control in tumour suppression
Shackelford, D. B., & Shaw, R. J. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2676 · Cited by 1,943
Flagged first, then by citations
Cited by
Sorted by citations
Items 301–382 of 382
Liang, H., Xu, L., Gao, A., Shao, Y., Yang, S., Jiang, Z., Ma, W., Zhu, S., Lin, T., & Zhang, X. (2019) · Neurological Research · doi:10.1080/01616412.2019.1611202 · Cited by 4
Wang, J., Lu, X., Zheng, K., & Liang, J. (2021) · Neuroreport · doi:10.1097/wnr.0000000000001582 · Cited by 4
Breast cancer therapy: from the perspective of glucose metabolism and glycosylation
Zhao, J., Sun, H., Wang, C., & Shang, D. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09466-w · Cited by 4
Glucose and glutamine metabolism-related protein expression in breast ductal carcinoma in situ
Ryu, H. J., & Koo, J. S. (2022) · Neoplasma · doi:10.4149/neo_2022_220103n3 · Cited by 4
Glucosamine-6 Phosphate N-Acetyltransferase (GNPNAT1/GNA1)
Dennis, J. W. (2014) · Springer eBooks · doi:10.1007/978-4-431-54240-7_148 · Cited by 4
Self-citationBarile, S. N., Magnifico, M. C., Poeta, E., Distelmaier, F., Viggiano, L., Balboni, N., Protti, M., Petralla, S., Pignataro, A., Volpe, G., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-08314-4 · Cited by 3
Glucose deprivation drives LIF-dependent lung cancer
Luciano‐Mateo, F., Moreno‐Càceres, J., Hernández-Madrigal, M., Püschel, F., Collado-Rodríguez, L., Favaro, F., Hijazo‐Pechero, S., Cruz‐Rodríguez, M., Jiménez-Hernández, F., Villagrasa-Araya, V., et al. (2026) · Nature Metabolism · doi:10.1038/s42255-025-01437-0 · Cited by 3
A reference dataset of O-GlcNAc proteins in quadriceps skeletal muscle from mice
Jaiswal, R., Liu, Y., Petriello, M. C., Zhang, X., Yi, Z., & Fehl, C. (2025) · Glycobiology · doi:10.1093/glycob/cwaf005 · Cited by 3
Al-Khalaifah, H. S., Tolba, S. A., Al-Nasser, A. Y., & Gouda, A. (2025) · Animals · doi:10.3390/ani15101386 · Cited by 3
Pastrana, C. I., Sgobba, M. N., González, F. J. N., Bermejo, J. V. D., Pierri, C. L., Lentini, G., Musio, B., Osman, T. K., Gallo, V., Duarte, I. F., et al. (2024) · Research in Veterinary Science · doi:10.1016/j.rvsc.2024.105419 · Cited by 3
Metabolic Pathways of Eukaryotes and Connection to Cell Mechanics
Mierke, C. T. (2020) · Biological and medical physics, biomedical engineering · doi:10.1007/978-3-030-58532-7_17 · Cited by 2
Cancer RNome: Evolution and Sustenance
Arora, M., & Kaul, D. (2018) · Springer eBooks · doi:10.1007/978-981-13-1568-8_3 · Cited by 3
SLC3A2 N-glycosylation and alternate evolutionary trajectories for amino acid metabolismPreprint
Zhang, C., Shafaq‐Zadah, M., Pawling, J., Ng, D. W. J., Hesketh, G. G., Dransart, E., Pacholczyk, K., Longo, J., Gingras, A., Penn, L. Z., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.11.15.516651 · Cited by 3
Self-citationO-GlcNAcylation regulates microglial neuroinflammation in Parkinson’s disease
Kim, D. Y., Kim, S.-M., Lee, C. J., & Han, I. (2026) · npj Parkinson s Disease · doi:10.1038/s41531-026-01319-6 · Cited by 2
Anastasiou, D., Locasale, J. W., & Heiden, M. G. V. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9780511979811.020 · Cited by 2
Metabolic pathway analysis of tumors using stable isotopes
Bi, Q., Zhao, J., Nie, J. H., & Huang, F. (2025) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2025.05.002 · Cited by 3
Simultaneous Quantification of Nucleotide Sugar Metabolism by LC and LC-MS
Nakajima, K., & Taniguchi, N. (2014) · Springer eBooks · doi:10.1007/978-4-431-54841-6_8 · Cited by 2
Progression of Lung Cancer: Role of Hypoxia and the Metabolic Tumor Microenvironment
Leithner, K., & Olschewski, H. (2017) · Springer eBooks · doi:10.1007/978-3-319-53659-0_18 · Cited by 2
Amino acid metabolism in fate decision of porcine immune cells: advances and beyond
Ren, W., Peng, B. I. N., Xia, Y., & Zhu, G. (2020) · Scientia Sinica Vitae · doi:10.1360/ssv-2020-0041 · Cited by 2
Coordination of Glucose and Glutamine Metabolism in Tendon Is Lost in Aging
Mlawer, S. J., Pinto, F. R., Sikes, K. J., & Connizzo, B. K. (2025) · Journal of Orthopaedic Research® · doi:10.1002/jor.26100 · Cited by 1
Shakya, R., Suraneni, P. K., Rahi, A., Young, M. Y., Cousino, E., Magdongon, C. B., Gajjela, R., Mattamana, B. B., Zaslavsky, A., Palapattu, G. S., et al. (2026) · Cell Communication and Signaling · doi:10.1186/s12964-026-02756-9 · Cited by 1
Insights into Neutrophil Dysfunction in Inherited Metabolic Disorders
Wolf, A., Montanelli, G., Mathis, D., Felser, A., Laemmle, A., Nuoffer, J., Gautschi, M., Bourquin, C., & Stojkov, D. (2026) · Journal of Innate Immunity · doi:10.1159/000552119 · Cited by 1
Wada, N., Nojima, S., Tahara, S., Ohshima, K., Kurashige, M., Kawasaki, K., Tone, M., Kusumoto, S., Ikeda, J., & Morii, E. (2018) · Pathology - Research and Practice · doi:10.1016/j.prp.2018.08.019 · Cited by 1
Solovyeva, E. Y., Карнеев, А. Н., Chekanov, A. V., Баранова, О. А., Shchelkonogov, V. A., Sinebryukhova, A. M., Farakhova, K. I., & Sorokoumova, G. M. (2019) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-019-00794-0 · Cited by 1
Advances in Research on the Relationship between Glutamine Metabolism and Breast Cancer
Wang, Y., Zhang, H., & Chu, Y. (2023) · International Journal of Biology and Life Sciences · doi:10.54097/ijbls.v3i1.8884 · Cited by 1
Satoh, M. S., St‐Pierre, G., Rancourt, A., Fillion, M., & Sato, S. (2025) · The FASEB Journal · doi:10.1096/fj.202500196r · Cited by 1
The Adaptor Protein p66Shc Inhibits mTOR-Dependent Anabolic Metabolism
Soliman, M. A., Rahman, A. M. A., Lamming, D. W., Birsoy, K., Pawling, J., Frigolet, M. E., Lu, H., Fantus, I. G., Pasculescu, A., Zheng, Y., et al. (2014) · Science Signaling · doi:10.1126/scisignal.2004785 · Cited by 43
Self-citationInsulin Resistance: A Link Between Obesity and Cancer
Sattar, S., Nisar, M. F., & Nwosu, O. K. (2021) · Springer eBooks · doi:10.1007/978-3-030-72999-8_5 · Cited by 1
Seo, Y., Chung, E. K., & Jung, B. H. (2023) · Biomedical Chromatography · doi:10.1002/bmc.5642 · Cited by 1
Correction of pathological conditions associated with insulin-resistant hyperglycaemia
Solovyeva, E. Y., Карнеев, А. Н., & Tyutyumova, E. A. (2016) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro201611691116-125 · Cited by 1
Peptide-based drugs to inhibit LDH5, a potential target for cancer therapy
Nadal‐Bufí, F. (2022) · Queensland University of Technology · doi:10.5204/thesis.eprints.232526 · Cited by 1
Shakya, R., Suraneni, P. K., Zaslavsky, A., Rahi, A., Magdongon, C. B., Gajjela, R., Mattamana, B. B., & Varma, D. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.14.618283 · Cited by 1
Hagland, H. R. (2012) · NORA - Norwegian Open Research Archives
Engineering Novel Detection and Treatment Strategies for Bacterial Therapy of Cancer
Panteli, J. T. (2021) · Scholarworks (University of Massachusetts Amherst) · doi:10.7275/6956795.0
Functional networks of events that modulate phenotypic manifestation of cancer
Thiagalingam, S. (2015) · Cambridge University Press eBooks · doi:10.1017/cbo9780511979811.012
Probing the anti-cancer mechanism of selenite : a metabolic approach.
Belshoff, A. C. (2013) · ThinkIR: The University of Louisville's Institutional Repository (University of Louisville) · doi:10.18297/etd/98
cells, and then triggers an anti-tumor immune response.
Okabe, Y., Medzhitov, R. M., Chiba, S., Ueki, H., Hangai, S., NISHIO, J., Negishi, H., & Saijo, S. (2014)
Role of SIRT6 in Metabolic Reprogramming During Colorectal Carcinoma
Sebastián, C. (2014) · Defense Technical Information Center (DTIC) · doi:10.21236/ada614181
Vasundharamma, J., AMAKSHAMMA, J., & S, V. (2016) · International Journal of Pharma and Bio Sciences · doi:10.22376/ijpbs.2016.7.4.b725-731
Theranostic Approaches for Pathway-Activated Systems in Oncology
Pham, L. V., Bryant, J. L., Yang, D. J., & Ford, R. J. (2017) · Springer eBooks · doi:10.1007/978-981-10-3349-0_2
Ma, X. (2014) · TSpace (University of Toronto)
Metabolic Dysregulation in Environmental Carcinogenesis and Toxicology
Robey, R. B. (2017) · John Wiley & Sons, Inc. eBooks · doi:10.1002/9781119023647.ch15
Structural and functional modifications of muscle proteins in response to glucosamine glycation
Hrynets, Y. (2015) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r3s756t11
Wang, G., Wang, J., Yin, P., Xu, K., Wang, Y., Shi, F., Gao, J., & Fu, X. (2018) · Journal of Cellular Biochemistry · doi:10.1002/jcb.27558
Investigating the role of amino acid transporter LAT3/SLC43A1 in prostate cancer
Zhang, K. (2019) · The Sydney eScholarship Repository (The University of Sydney)
Minh, G. L., & Reginato, M. J. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820472-6.00038-4
The role of NFκB in glucose import and survival of B-cell lymphomas
Sommermann, T. G. (2012) · OPUS FAU (Kooperativer Bibliotheksverbund Berlin-Brandenburg (KOBV), on behalf of the Universitätsbibliothek Erlangen-Nürnberg)
Chirila, A. (2019) · TSpace (University of Toronto)
Wibowo, A. (2014) · SKRIPSI Jurusan Teknik Mesin - Fakultas Teknik UM
Fukuda, M., & Bao, X. (2012) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.715497908.791052865
Simultaneous Quantification of Nucleotide Sugar Metabolism by LC and LC-MS
Nakajima, K., & Taniguchi, N. (2014) · Springer eBooks · doi:10.1007/978-4-431-54836-2_8-1
Glutamine availability regulates cDC subsets in tissuePreprint
Lobel, G. P., Han, N., Arocho, W. A. M., Silber, M., Shoush, J., Noji, M., To, T. K. J., Zhai, L., Lesner, N. P., Simon, M. C., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.17.613574
LncRNA: Secret Regulators of Cancer Metabolism
Demirkaya, D. B., & Yalçın, S. (2024) · Interdisciplinary cancer research · doi:10.1007/16833_2024_470
Kroef, V., Hund, L., Abbas, Y. B., Tamura, N., Fröhlich, J., Huber, A., Ali, S. M., Wischhof, L., Scheiblich, H., Giavalisco, P., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.20.671247
Chen, M., Li, Y., Xu, X., Wang, S., Liu, Z., Qi, S., Si, D., Man, Z., Deng, S., Liu, G., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26112970
Chen, M., Li, Y., Xu, X., Wang, S., Liu, Z., Qi, S., Si, D., Man, Z., Deng, S., Liu, G., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26739321
Chen, M., Li, Y., Xu, X., Wang, S., Liu, Z., Qi, S., Si, D., Man, Z., Deng, S., Liu, G., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26113089
Chen, M., Li, Y., Xu, X., Wang, S., Liu, Z., Qi, S., Si, D., Man, Z., Deng, S., Liu, G., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26739318
Chen, M., Li, Y., Xu, X., Wang, S., Liu, Z., Qi, S., Si, D., Man, Z., Deng, S., Liu, G., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26739315
Jiang, J., He, H., Wang, X., Jin, S., Xiao, W., Xie, Y., Wei, E., Qian, C., Fu, J., Wang, J., et al. (2026) · Biology Direct · doi:10.1186/s13062-026-00746-y
Targeting sialic acid metabolism: a therapeutic strategy against gastric cancer driven by WZ35
Hong, B., Wang, Y., Feng, X., Wei, L., Huang, Y., Zhang, X., Xu, L., Jin, P., Huang, L., Li, R., et al. (2026) · Cellular Oncology · doi:10.1007/s13402-026-01194-6
Metabolic characterisation of skeletal muscle stem cells in distinct physiological states
Pala, F. (2017) · theses.fr (ABES) · doi:10.70675/ba751aadz6065z4221zbe6ez3b3e7cb993cc
Stage-specific changes in the Krebs cycle network regulate human erythroid differentiation
Romano, M. (2018) · theses.fr (ABES) · doi:10.70675/4312681cz0207z4923zb100z879f8a73681c
Plant virus-derived nanoparticles for the imaging and treatment of cancer
Gamper, C. (2019) · theses.fr (ABES) · doi:10.70675/844eefddz7e34z4b59z978bzda1d6c32d297
Rôle du transporteur mitochondrial UCP2 dans la leucémie
Sancerni, T. (2019) · theses.fr (ABES) · doi:10.70675/c0f1a3a3z992az4717zb426z210e51dadf82
Hétérogénéité métabolique des gliomes : apport de la spectroscopie RMN HRMAS
Bund, C. (2020) · theses.fr (ABES) · doi:10.70675/2f880f7az9a01z463fz9f4az0dcaad5fcf59
Étude de l’influence de la glutaminolyse des macrophages dans les maladies cardio-métaboliques
Merlin, J. (2020) · theses.fr (ABES) · doi:10.70675/68e10f28zf840z48bfz9bacz5511a3a2b208
Etude des adaptations métaboliques tissulaires et systémiques dans les leucémies aigues myéloides
Cognet, G. (2021) · theses.fr (ABES) · doi:10.70675/d797432ezefc0z415fzb426z00a7f89c80fa
Zhang, P., Duan, X., Wang, Y., Bao, A., Ma, X., Chen, S. T., Zhang, Y., & Liu, S. (2026) · Biology · doi:10.3390/biology15130982
The role of RNA modifications in cancer metabolism
Zhang, J., & Xu, K. (2026) · Genes & Diseases · doi:10.1016/j.gendis.2026.102365
Sun, C., Wu, S., Li, Z., Huang, C., & Wu, D. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.118376
Excess glutamine rewires endothelial cell metabolism
Kheradmand, M., Zhou, X., Okunrinboye, F., Sriram, G., & Clyne, A. M. (2026) · Metabolomics · doi:10.1007/s11306-026-02515-4
The Glutamine-O-GlcNAc: A central metabolic-signaling crosstalk network in physiology and disease
Shi, R., Zhi, Y., Li, S., Ren, W.-H., Gao, L., & Zhi, K. (2026) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2026.101804
Dietary Control of MGAT-Dependent N -Glycan Branching: Implications for Metabolic Homeostasis
Wang, Y., Zhao, C., Cheng, R., He, B., Yang, H., Ni, Q., Cheng, P., Kortesniemi, M. K., Tian, J., Baoru, Y., et al. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6c08847
Ebelt, N. D., Loganathan, S., Avsharian, L. C., Dąbrowska, K., Hansen, N. F., Pathak, K. V., Pirrotte, P., & Manuel, E. R. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.10.01.756059
Jin, X., Xu, Y., Ling, K., Li, H., Wang, J., Liu, J., Yang, X., & 木海琦 (2026) · Cellular Signalling · doi:10.1016/j.cellsig.2026.112937
BindingDB (2021) · UC San Diego · doi:10.7270/q2ng4v40
Metadata
- Authors
- Wellen, K. E., Lu, C., Mancuso, A., Lemons, J. M. S., Ryczko, M., Dennis, J. W., Rabinowitz, J. D., Coller, H. A., & Thompson, C. B.
- Affiliations
- University of Pennsylvania (US)
- Princeton University (US)
- Mount Sinai Hospital (CA)
- ORCID
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2010-11-24
- Volume
- 24
- Issue
- 24
- Pages
- 2784-2799
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- PMC
- PMC3003197
- OpenAlex
- W2034586537
- Cited by
- 377
- References
- 55
- Citations by year
- 2026: 14 · 2025: 15 · 2024: 14 · 2023: 15 · 2022: 29 · 2021: 25 · 2020: 17 · 2019: 24 · 2018: 36 · 2017: 24 · 2016: 28 · 2015: 29 · 2014: 34 · 2013: 26 · 2012: 35
- Type
- posted content
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Genes & Development (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Damon Runyon Cancer Research Foundation
- National Institutes of Health
- National Cancer Institute (P01CA104838, R01CA105463)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- hexosamine biosynthetic pathway, glutamine uptake, glucose metabolism, interleukin-3, CD123, N-acetylglucosamine, TCA cycle, mitochondrial metabolism, glucose deprivation, cell growth, growth factor signaling, receptor down-regulation
- MeSH terms
- Acetylglucosamine, Animals, Atrophy, Biological Transport, Cell Survival, Citric Acid Cycle, Glucose, Glutamine, Hexosamines, Interleukin-3, Signal Transduction, Intercellular Signaling Peptides and Proteins, Mice, Metabolic Networks and Pathways
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
