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The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.

Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein

Open access
Zhao, Bin, Li, Li, Lu, Qing, Wang, Lloyd H., Liu, Chen-Ying, Lei, Qunying, Guan, Kun-Liang·2011·Genes & Development
DOI 10.1101/gad.2000111
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Abstract

The Yes-associated protein (YAP) is a transcription coactivator that plays a crucial role in organ size control by promoting cell proliferation and inhibiting apoptosis. The Hippo tumor suppressor pathway inhibits YAP through phosphorylation-induced cytoplasmic retention and degradation. Here we report a novel mechanism of YAP regulation by angiomotin (AMOT) family proteins via a direct interaction. Knockdown of AMOT family protein AMOTL2 in polarized Madin-Darby canine kidney (MDCK) cells leads to YAP activation, as indicated by decreased YAP tight junction localization, attenuated YAP phosphorylation, accumulation of nuclear YAP, and induction of YAP target gene expression. Transcriptional coactivator with PDZ-binding motif (TAZ), the YAP paralog, is also regulated by AMOT in a similar fashion. Furthermore, AMOTL2 knockdown results in loss of cell contact inhibition in a manner dependent on the functions of YAP and TAZ. Our results indicate a potential tumor-suppressing role of AMOT family proteins as components of the Hippo pathway, and demonstrate a novel mechanism of YAP and TAZ inhibition by AMOT-mediated tight junction localization. These observations provide a potential link between the Hippo pathway and cell contact inhibition.

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Metadata

Authors
Zhao, B., Li, L., Lu, Q., Wang, L. H., Liu, C.-Y., Lei, Q., & Guan, K.-L.
Venue
Genes & Development
Publisher
Cold Spring Harbor Laboratory
Published
2011-01-01
Volume
25
Issue
1
Pages
51-63
ISSN
  • 0890-9369 (ISSN-L)
  • 1549-5477
DOI
10.1101/gad.2000111
OpenAlex
W2143727653
Cited by
665
References
4
Type
posted content
Language
en
Open access
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CoChat. (2026). Citation check: Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. https://app.cochat.ai/papers/10.1101/gad.2000111
The paper
Zhao, B., Li, L., Lu, Q., Wang, L. H., Liu, C.-Y., Lei, Q., & Guan, K.-L. (2011). Angiomotin is a novel Hippo pathway component that inhibits YAP oncoprotein. Genes & Development. https://doi.org/10.1101/gad.2000111

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.