The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
A double take on bivalent promoters
Open accessAbstract
Histone modifications and chromatin-associated protein complexes are crucially involved in the control of gene expression, supervising cell fate decisions and differentiation. Many promoters in embryonic stem (ES) cells harbor a distinctive histone modification signature that combines the activating histone H3 Lys 4 trimethylation (H3K4me3) mark and the repressive H3K27me3 mark. These bivalent domains are considered to poise expression of developmental genes, allowing timely activation while maintaining repression in the absence of differentiation signals. Recent advances shed light on the establishment and function of bivalent domains; however, their role in development remains controversial, not least because suitable genetic models to probe their function in developing organisms are missing. Here, we explore avenues to and from bivalency and propose that bivalent domains and associated chromatin-modifying complexes safeguard proper and robust differentiation.
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Cites
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Cited by
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Epigenetic balance of gene expression by Polycomb and COMPASS families
Piunti, A., & Shilatifard, A. (2016) · Science · doi:10.1126/science.aad9780 · Cited by 524
Maintaining cell identity: PRC2-mediated regulation of transcription and cancer
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Metadata
- Authors
- Voigt, P., Tee, W.-W., & Reinberg, D.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2013-06-15
- Volume
- 27
- Issue
- 12
- Pages
- 1318-1338
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W2022140142
- Cited by
- 815
- References
- 29
- Type
- posted content
- Language
- en
- Open access
- diamond
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