The DOI matches its Crossref record; 168 of the 168 references it cites were found in a registry or an index.
DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos
Open accessAbstract
Methylation of DNA is an essential epigenetic control mechanism in mammals. During embryonic development, cells are directed toward their future lineages, and DNA methylation poses a fundamental epigenetic barrier that guides and restricts differentiation and prevents regression into an undifferentiated state. DNA methylation also plays an important role in sex chromosome dosage compensation, the repression of retrotransposons that threaten genome integrity, the maintenance of genome stability, and the coordinated expression of imprinted genes. However, DNA methylation marks must be globally removed to allow for sexual reproduction and the adoption of the specialized, hypomethylated epigenome of the primordial germ cell and the preimplantation embryo. Recent technological advances in genome-wide DNA methylation analysis and the functional description of novel enzymatic DNA demethylation pathways have provided significant insights into the molecular processes that prepare the mammalian embryo for normal development.
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Cites
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Mechanisms regulating zygotic genome activation
Schulz, K. N., & Harrison, M. M. (2019) · Nature Reviews Genetics · doi:10.1038/s41576-018-0087-x · Cited by 555
Dynamics of the epigenetic landscape during the maternal-to-zygotic transition
Eckersley-Maslin, M. A., Alda-Catalinas, C., & Reik, W. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0008-z · Cited by 431
Environmental Endocrine-Disrupting Chemical Exposure: Role in Non-Communicable Diseases
Kumar, M., Sarma, D. K., Shubham, S., Kumawat, M., Verma, V., Prakash, A., & Tiwari, R. (2020) · Frontiers in Public Health · doi:10.3389/fpubh.2020.553850 · Cited by 391
Single-cell multi-omics sequencing of mouse early embryos and embryonic stem cells
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Metadata
- Authors
- Messerschmidt, D. M., Knowles, B. B., & Solter, D.
- Venue
- Genes & Development
- Publisher
- Cold Spring Harbor Laboratory
- Published
- 2014-04-15
- Volume
- 28
- Issue
- 8
- Pages
- 812-828
- ISSN
- 0890-9369 (ISSN-L)
- 1549-5477
- OpenAlex
- W1996431759
- Cited by
- 729
- References
- 168
- Type
- posted content
- Language
- en
- Open access
- diamond
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- Messerschmidt, D. M., Knowles, B. B., & Solter, D. (2014). DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos. Genes & Development. https://doi.org/10.1101/gad.234294.113
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