PreprintCited by 150Neurogenesis and neuroplasticity mechanismsDevelopmental Biology and Gene RegulationCongenital gastrointestinal and neural anomalies

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The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord

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Müller, Thomas, Anlag, Katrin, Wildner, Hendrik, Britsch, Stefan, Treier, Mathias, Birchmeier, Carmen·2005·Genes & Development

DOI 10.1101/gad.326105PMC PMC1065726

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Abstract

Neurons of the dorsal horn integrate and relay sensory information and arise during development in the dorsal spinal cord, the alar plate. Class A and B neurons emerge in the dorsal and ventral alar plate, differ in their dependence on roof plate signals for specification, and settle in the deep and superficial dorsal horn, respectively. We show here that the basic helix-loop-helix (bHLH) gene Olig3 is expressed in progenitor cells that generate class A (dI1-dI3) neurons and that Olig3 is an important factor in the development of these neuronal cell types. In Olig3 mutant mice, the development of class A neurons is impaired; dI1 neurons are generated in reduced numbers, whereas dI2 and dI3 neurons are misspecified and assume the identity of class B neurons. Conversely, Olig3 represses the emergence of class B neurons in the chick spinal cord. We conclude that Olig3 expression distinguishes the two major classes of progenitors in the dorsal spinal cord and determines the distinct specification program of class A neurons.

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Authors: Müller, T., Anlag, K., Wildner, H., Britsch, S., Treier, M., & Birchmeier, C.
Affiliations: Max Delbrück Center (DE)
ORCID: Müller, Thomas
Wildner, Hendrik
Britsch, Stefan
Treier, Mathias
Birchmeier, Carmen
Venue: Genes & Development
Publisher: Cold Spring Harbor Laboratory
Published: 2005-03-15
Volume: 19
Issue: 6
Pages: 733-743
ISSN: 0890-9369 (ISSN-L)
1549-5477
DOI: 10.1101/gad.326105
PMC: PMC1065726
OpenAlex: W2038998122
Cited by: 150
References: 48
Citations by year: 2026: 3 · 2025: 6 · 2024: 8 · 2023: 1 · 2022: 4 · 2021: 9 · 2020: 6 · 2019: 7 · 2018: 4 · 2017: 6 · 2016: 6 · 2015: 7 · 2014: 9 · 2013: 9 · 2012: 9
Type: posted content
Language: en
Open access: green
dx.doi.org
Locations: Genes & Development (publishedVersion)
PubMed Central (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed (publishedVersion)
MDC Repository (Max-Delbrueck-Center for Molecular Medicine) (acceptedVersion)
Funders: Deutsche Forschungsgemeinschaft
Bundesministerium für Bildung und Forschung
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Health Sciences › Medicine › Surgery › Congenital gastrointestinal and neural anomalies
Keywords: bHLH transcription factors, dorsal horn neurons, spinal cord development, alar plate, neuronal specification, dorsal interneurons, progenitor cells, chick embryo
MeSH terms: Animals, Bromodeoxyuridine, Cell Differentiation, Chick Embryo, Fluorescent Antibody Technique, Genetic Vectors, Mutation, Spinal Cord, Stem Cells, Transcription Factors, Blotting, Southern, In Situ Hybridization, Gene Transfer Techniques, Electroporation, Reverse Transcriptase Polymerase Chain Reaction, Posterior Horn Cells, Mice, Basic Helix-Loop-Helix Proteins

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The bHLH factor Olig3 coordinates the specification of dorsal neurons in the spinal cord

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